STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO3380Conserved hypothetical protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. (265 aa)    
Predicted Functional Partners:
SCO3383
Putative pantoate-amino acid ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.
  
 
 0.997
SCO5568
Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family.
 
  
 0.955
SCO3384
Conserved hypothetical protein; SCE126.02c, unknown, len: 420aa; similar to TR:O06279 (EMBL:Z95557) hypothetical protein from Mycobacterium tuberculosis (303 aa) fasta scores; opt: 683, z-score: 584.3, E(): 3.1e-25, (49.3% identity in 284 aa overlap).
 
   
 0.945
SCO4738
SC6G4.16c, coaA, probable pantothenate kinase, len: 329 aa; similar to e.g. COAA_ECOLI pantothenate kinase (EC 2.7.1.33) (316 aa), fasta scores; opt: 1100 z-score: 1601.0 E(): 0, 51.4% identity in 315 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop).
     
 0.941
SCO1477
Putative flavoprotein homologue (partial); Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family.
  
 
 0.938
SCO3381
SCE94.32c, nadC, nicotinate-nucleotide pyrophophorylase, len: 329 aa; similar to many e.g. SW:NADC_MYCTU NadC, nicotinate-nucleotide pyrophophorylase from Mycobacterium tuberculosis (285 aa) fasta scores; opt: 909, z-score: 1017.8, E(): 0, (57.3% identity in 267 aa overlap); Belongs to the NadC/ModD family.
       0.875
SCO3382
L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate.
       0.875
SCO0978
L-aspartate-alpha-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
  
  
 0.859
SCO3542
Integral membrane protein with kinase activity; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
   
   0.794
SCO3385
Putative L-allo-threonine aldolase; SCE126.03, possible lyase, len: 403aa; weakly similar to many eg. SW:LTAA_AERJA L-allo-threonine aldolase from Aeromonas jandaei DK-39 (338 aa) fasta scores; opt: 257, z-score: 293.4, E(): 5e-09, (31.4% identity in 255 aa overlap).
       0.767
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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