STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO3845SCH69.15, possible protein phosphatase, len: 515aa; similar to many of undefined function egs. TR:P71588 (EMBL:Z80233) hypothetical protein from Mycobacterium tuberculosis (514 aa) fasta scores; opt: 989, z-score: 916.0, E(): 0, (42.9% identity in 536 aa overlap) and TR:Q50188 (EMBL:Z70722) putative phophoprotein phosphatase from Mycobacterium leprae (509 aa) fasta scores; opt: 966, z-score: 895.0, E(): 0, (40.0% identity in 530 aa overlap). Contains 2 Pfam matches to entry PF00481 PP2C, Protein phosphatase 2C. could have a role in signalling. (515 aa)    
Predicted Functional Partners:
SCO3848
SCH69.18, possible serine/threonine protein kinase, len: 673 aa; similar to many e.g. TR:P71584 (EMBL:Z80233) putative serine/threonine protein kinase from Mycobacterium tuberculosis (626 aa) fasta scores; opt: 1185, z-score: 1028.0, E(): 0, (42.0% identity in 646 aa overlap) and TR:P95308 (EMBL:X99618) serine/threonine protein kinase from Mycobacterium tuberculosis (662 aa) fasta scores; opt: 598, z-score: 522.8, E(): 8.6e-22, (33.9% identity in 345 aa overlap). Also similar to SCGD3.21c from Streptomyces coelicolor (522 aa) fasta scores; opt: 1104, z-score: 1039.5, E(): 0, (50.0% ide [...]
 
 0.997
SCO3844
SCH69.14, putative secreted protein, len: 172 aa; similar to TR:P71589 (EMBL:Z80233) hypothetical protein from Mycobacterium tuberculosis (155 aa) fasta scores; opt: 389, z-score: 442.8, E(): 2.5e-17, (46.2% identity in 171 aa overlap). Contains possible N-terminal region signal peptide sequence.
 
 
 0.992
SCO3843
Hypothetical protein; SCH69.13, unknown, len: 290 aa; similar to the N-terminal region of TR:P71590 (EMBL:Z80233) hypothetical protein from Mycobacterium tuberculosis (527 aa) fasta scores; opt: 268, z-score: 221.4, E(): 5.3e-05, (28.1% identity in 217 aa overlap).
 
 
 0.986
SCO2110
SC6E10.04, pkaF, probable eukaryotic-type serine/threonine protein kinase, len: 667 aa; previously sequenced as TR:Q9ZNB3 (EMBL:AB019394) S.coelicolor eukaryotic-type protein kinase (629 aa) and identical to that sequence, but with a different putative start codon. Similar to many e.g. SW:PKN2_MYXXA (EMBL:M94857), Pkn2, Myxococcus xanthus serine/threonine protein kinase involved in regulation of beta-lactamase secretion (830 aa), fasta scores; opt: 564 z-score: 531.4 E(): 2.8e-22, 35.5% identity in 366 aa overlap. Similar to many hypothetical protein serine/threonine protein kinases fr [...]
 
 0.985
SCO3847
SCH69.17, probable secreted penicillin-binding protein, len: 490 aa; similar to many e.g. TR:P71586 (EMBL:Z80233) putative penicillin-binding protein from Mycobacterium tuberculosis (491 aa) fasta scores; opt: 112,1 z-score: 1262.1, E(): 0, (39.3% identity in 499 aa overlap) and SW:PBPC_BACSU penicillin-binding protein 3 from Bacillus subtilis (668 aa) fasta scores; opt: 447, z-score: 502.5, E(): 1.2e-20, (29.0% identity in 386 aa overlap). Also similar to SC6G9.32 from Streptomyces coelicolor (485 aa) fasta scores; opt: 1493, z-score: 1531.4, E(): 0, (49.4% identity in 488 aa overlap) [...]
  
  
 0.953
SCO3846
SCH69.16, probable FtsW/RodA/SpoVE family cell cycle protein, len: 479aa; similar to many egs. SW:FTSW_MYCTU probable cell division protein FtsW from Mycobacterium tuberculosis (469 aa) fasta scores; opt: 1367, z-score: 1568.6, E(): 0, (48.8% identity in 451 aa overlap) and SW:SP5E_BACSU stage V sporulation protein E from Bacillus subtilis (366 aa) fasta scores; opt: 496, z-score: 572.9, E(): 1.4e-24, (31.7% identity in 391 aa overlap). Also similar to SC6G9.31 from Streptomyces coelicolor (446 aa) fasta scores; opt: 1132, z-score: 1182.0, E(): 0, (58.6% identity in 444 aa overlap). Co [...]
 
  
 0.914
SCO3821
SCGD3.22, pksC, serine/threonine protein kinase, len: 556 aa; previously sequenced as (EMBL:AF094711), PksC, Streptomyces coelicolor serine/threonine protein kinase (556 aa). Highly similar to SCGD3.21c which lies upstream, on the opposite strand. Contains Pfam match to entry PF00069 pkinase, Eukaryotic protein kinase domain, PS00108 Serine/Threonine protein kinases active-site signature and PS00107 Protein kinases ATP-binding region signature.
 
 
 0.882
SCO1472
SCL6.29c, conserved hypothetical Sun-family protein, len: 475 aa; similar to SW:SUN_BACSU (EMBL:Y13937) Bacillus subtilis sun protein, 447 aa; fasta scores: opt: 637 z-score: 711.7 E(): 3.2e-32; 32.0% identity in 472 aa overlap. Contains Pfam match to entry PF01029 NusB, NusB family and to entry PF01189 Nol1_Nop2_Sun, NOL1/NOP2/sun family and match to Prosite entry PS01153 NOL1/NOP2/sun family signature; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
 
 
 0.871
SCO2244
SC1G2.06c, probable serine/threonine protein kinase, len: 686 aa. Highly similar to many serine/threonine protein kinases including: Streptomyces coelicolor SW:AFSK_STRCO (EMBL:D15062) AfsK (799 aa), fasta scores opt: 818 z-score: 736.0 E():0 34.2% identity in 658 aa overlap and Thermomonospora curvata SW:PKWA_THECU (EMBL:U23820) PkwA (742 aa), fasta scores opt: 1065 z-score: 956.9 E():0 37.0% identity in 763 aa overlap. Contains a Pfam match to entry PF00069 pkinase, Eukaryotic protein kinase domain and 3xPfam matches to entry PF00400 WD40, WD domain, G-beta repeat. Also contains Pros [...]
 
 
 0.858
SCO1551
SCL11.07, possible eukaryotic-type protein kinase, len: 493 aa; similar to TR:Q9ZN80 (EMBL:AB021679) Streptomyces coelicolor PkaG, 592 aa; fasta scores: opt: 926 z-score: 659.3 E(): 2.6e-29; 41.0% identity in 417 aa overlap and N-terminal region similar to SW:AFSK_STRGR0 (EMBL:D45246) Streptomyces griseus serine/threonine protein kinase AfsK (EC 2.7.1.-) 807 aa; fasta scores: opt: 871 z-score: 619.6 E(): 4.3e-27; 39.3% identity in 435 aa overlap. Contains Pfam match to entry PF00069 pkinase, Eukaryotic protein kinase domain and matches to Prosite entries PS00107 Protein kinases ATP-bin [...]
 
 
 0.852
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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