STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
SCO4151Putative acetyltransferase; Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol. Belongs to the acetyltransferase family. MshD subfamily. (309 aa)    
Predicted Functional Partners:
SCO5126
Conserved hypothetical protein; Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2- deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway; Belongs to the MshB deacetylase family.
  
   
 0.960
SCO1663
Putative cysteinyl-tRNA synthetase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins.
 
   
 0.940
SCO4967
Conserved hypothetical protein; A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S- conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics; Belongs to the MshB deacetylase family. Mca subfamily.
  
   
 0.879
SCO4204
Putative glycosyltransferase; Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2- deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway; Belongs to the glycosyltransferase group 1 family. MshA subfamily.
 
   
 0.857
SCO2634
SC8E4A.04c, hypothetical protein, len: 216 aa; similar to various hypothetical proteins, e.g. TR:O53193 (EMBL:AL021246) Mycobacterium tuberculosis hypothetical 23.0 kD protein MTV008.22c, 207 aa; fasta scores: opt: 789 z-score: 898.4 E(): 0; 54.9% identity in 213 aa overlap.
 
   0.788
SCO3647
SCH10.25c, conserved hypothetical protein, len: 143 aa; unknown function, similar to TR:O06310 (EMBL:Z95324) Mycobacterium tuberculosis hypothetical protein (145 aa), fasta scores; opt: 497 z-score: 431.5 E(): 1e-16, 55.8% identity in 138 aa overlap and TR:O69598 (EMBL:AL023514) Mycobacterium leprae hypothetical protein (137 aa) (56.2% identity in 130 aa overlap).
 
     0.703
SCO5438
Thioredoxin; SC6A11.14, trxA2, thioredoxin, len: 104 aa; similar to many e.g. SW:P52230 (THIO_STRCO) thioredoxin TrxA from Streptomyces coelicolor (110 aa) fasta scores: opt: 360, z-score: 470.8, E(): 8.2e-19, 47.5% identity in 101 aa overlap. Contains Pfam match to entry PF00085 thiored, Thioredoxin and Prosite match to PS00194 Thioredoxin family active site; Belongs to the thioredoxin family.
     
 0.661
SCO1129
2SCG38.22, probable secreted deacetylase, len: 282 aa; similar to SW:NODB_RHIME (EMBL:X01649) Rhizobium meliloti chitooligosaccharide deacetylase (EC 3.5.1.-) NodB, 217 aa; fasta scores: opt: 363 z-score: 383.5 E(): 6.5e-14; 38.5% identity in 195 aa overlap. Contains Pfam match to entry PF01522 Polysac_deacet, Polysaccharide deacetylase and possible N-terminal region signal peptide sequence.
     
 0.637
SCO4145
Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP); Belongs to the polyphosphate kinase 1 (PPK1) family.
      0.622
SCO1143
Conserved hypothetical protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.
  
    0.607
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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