node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SCO1496 | SCO4506 | gene:17759082 | gene:17762151 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Conserved hypothetical protein; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2); Belongs to the MqnA/MqnD family. MqnA subfamily. | 0.848 |
SCO1496 | SCO4784 | gene:17759082 | gene:17762433 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | SCD63.16c, hypothetical protein, len: 110 aa; similar to SW:Y948_MYCTU (EMBL:Z79700) Mycobacterium tuberculosis hypothetical 11.8 kD protein RV0984c, MTCY10D7.26, 105 aa; fasta scores: opt: 195 z-score: 252.8 E(): 1.2e-06; 47.2% identity in 72 aa overlap. | 0.972 |
SCO4326 | SCO4327 | gene:17761971 | gene:17761972 | Conserved hypothetical protein; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). | Conserved hypothetical protein SCD12A.10c; Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). Does not accept aminodeoxyfutalosine (AFL) as a substrate; Belongs to the PNP/UDP phosphorylase family. Futalosine hydrolase subfamily. | 0.998 |
SCO4326 | SCO4490 | gene:17761971 | gene:17762135 | Conserved hypothetical protein; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). | SCD69.10, putative decarboxylase, len: 485 aa; similar to SW:Y209_ARCFU (EMBL:AE001091) Archaeoglobus fulgidus hypothetical protein AF0209, 481 aa; fasta scores: opt: 1557 z-score: 1800.8 E(): 0; 48.6% identity in 484 aa overlap and to SW:P26615 (UBID_ECOLI) 3-Octaprenyl-4-hydroxybenzoate carboxy-lyase from Escherichia coli (497 aa) fasta scores; opt: 1293, Z-score: 1478.5, 40.162% identity (41.336% ungapped) in 493 aa overlap. Contains Pfam match to entry PF01977 UPF0096, Protein of unknown function. | 0.932 |
SCO4326 | SCO4491 | gene:17761971 | gene:17762136 | Conserved hypothetical protein; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). | SCD69.11, probable octaprenyltransferase, len: 301 aa; similar to TR:AAF10428 (EMBL:AE001939) Deinococcus radiodurans 4-hydroxybenzoate octaprenyltransferase DR0851, 313 aa; fasta scores: opt: 794 z-score: 949.5 E(): 0; 44.7% identity in 302 aa overlap and to SW:UBIA_ECOLI (EMBL:M93136) Escherichia coli 4-hydroxybenzoate octaprenyltransferase (EC 2.5.1.-) UbiA, 290 aa; fasta scores: opt: 299 z-score: 362.7 E(): 9.7e-13; 27.9% identity in 276 aa overlap. Contains Pfam match to entry PF01040 UbiA, UbiA prenyltransferase family. Contains also possible hydrophobic membrane spanning regions. | 0.956 |
SCO4326 | SCO4492 | gene:17761971 | gene:17762137 | Conserved hypothetical protein; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). | Putative octaprenyl carboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | 0.933 |
SCO4326 | SCO4494 | gene:17761971 | gene:17762139 | Conserved hypothetical protein; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). | Conserved hypothetical protein; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. | 0.958 |
SCO4326 | SCO4506 | gene:17761971 | gene:17762151 | Conserved hypothetical protein; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). | Conserved hypothetical protein; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2); Belongs to the MqnA/MqnD family. MqnA subfamily. | 0.984 |
SCO4326 | SCO4550 | gene:17761971 | gene:17762195 | Conserved hypothetical protein; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). | Conserved hypothetical protein; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). | 0.999 |
SCO4326 | SCO4556 | gene:17761971 | gene:17762201 | Conserved hypothetical protein; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). | Putative ubiquinone/menaquinone methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). | 0.777 |
SCO4327 | SCO4326 | gene:17761972 | gene:17761971 | Conserved hypothetical protein SCD12A.10c; Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). Does not accept aminodeoxyfutalosine (AFL) as a substrate; Belongs to the PNP/UDP phosphorylase family. Futalosine hydrolase subfamily. | Conserved hypothetical protein; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). | 0.998 |
SCO4327 | SCO4490 | gene:17761972 | gene:17762135 | Conserved hypothetical protein SCD12A.10c; Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). Does not accept aminodeoxyfutalosine (AFL) as a substrate; Belongs to the PNP/UDP phosphorylase family. Futalosine hydrolase subfamily. | SCD69.10, putative decarboxylase, len: 485 aa; similar to SW:Y209_ARCFU (EMBL:AE001091) Archaeoglobus fulgidus hypothetical protein AF0209, 481 aa; fasta scores: opt: 1557 z-score: 1800.8 E(): 0; 48.6% identity in 484 aa overlap and to SW:P26615 (UBID_ECOLI) 3-Octaprenyl-4-hydroxybenzoate carboxy-lyase from Escherichia coli (497 aa) fasta scores; opt: 1293, Z-score: 1478.5, 40.162% identity (41.336% ungapped) in 493 aa overlap. Contains Pfam match to entry PF01977 UPF0096, Protein of unknown function. | 0.866 |
SCO4327 | SCO4491 | gene:17761972 | gene:17762136 | Conserved hypothetical protein SCD12A.10c; Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). Does not accept aminodeoxyfutalosine (AFL) as a substrate; Belongs to the PNP/UDP phosphorylase family. Futalosine hydrolase subfamily. | SCD69.11, probable octaprenyltransferase, len: 301 aa; similar to TR:AAF10428 (EMBL:AE001939) Deinococcus radiodurans 4-hydroxybenzoate octaprenyltransferase DR0851, 313 aa; fasta scores: opt: 794 z-score: 949.5 E(): 0; 44.7% identity in 302 aa overlap and to SW:UBIA_ECOLI (EMBL:M93136) Escherichia coli 4-hydroxybenzoate octaprenyltransferase (EC 2.5.1.-) UbiA, 290 aa; fasta scores: opt: 299 z-score: 362.7 E(): 9.7e-13; 27.9% identity in 276 aa overlap. Contains Pfam match to entry PF01040 UbiA, UbiA prenyltransferase family. Contains also possible hydrophobic membrane spanning regions. | 0.951 |
SCO4327 | SCO4492 | gene:17761972 | gene:17762137 | Conserved hypothetical protein SCD12A.10c; Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). Does not accept aminodeoxyfutalosine (AFL) as a substrate; Belongs to the PNP/UDP phosphorylase family. Futalosine hydrolase subfamily. | Putative octaprenyl carboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | 0.890 |
SCO4327 | SCO4494 | gene:17761972 | gene:17762139 | Conserved hypothetical protein SCD12A.10c; Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). Does not accept aminodeoxyfutalosine (AFL) as a substrate; Belongs to the PNP/UDP phosphorylase family. Futalosine hydrolase subfamily. | Conserved hypothetical protein; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. | 0.947 |
SCO4327 | SCO4506 | gene:17761972 | gene:17762151 | Conserved hypothetical protein SCD12A.10c; Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). Does not accept aminodeoxyfutalosine (AFL) as a substrate; Belongs to the PNP/UDP phosphorylase family. Futalosine hydrolase subfamily. | Conserved hypothetical protein; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2); Belongs to the MqnA/MqnD family. MqnA subfamily. | 0.982 |
SCO4327 | SCO4550 | gene:17761972 | gene:17762195 | Conserved hypothetical protein SCD12A.10c; Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). Does not accept aminodeoxyfutalosine (AFL) as a substrate; Belongs to the PNP/UDP phosphorylase family. Futalosine hydrolase subfamily. | Conserved hypothetical protein; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). | 0.999 |
SCO4327 | SCO4556 | gene:17761972 | gene:17762201 | Conserved hypothetical protein SCD12A.10c; Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). Does not accept aminodeoxyfutalosine (AFL) as a substrate; Belongs to the PNP/UDP phosphorylase family. Futalosine hydrolase subfamily. | Putative ubiquinone/menaquinone methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). | 0.789 |
SCO4490 | SCO4326 | gene:17762135 | gene:17761971 | SCD69.10, putative decarboxylase, len: 485 aa; similar to SW:Y209_ARCFU (EMBL:AE001091) Archaeoglobus fulgidus hypothetical protein AF0209, 481 aa; fasta scores: opt: 1557 z-score: 1800.8 E(): 0; 48.6% identity in 484 aa overlap and to SW:P26615 (UBID_ECOLI) 3-Octaprenyl-4-hydroxybenzoate carboxy-lyase from Escherichia coli (497 aa) fasta scores; opt: 1293, Z-score: 1478.5, 40.162% identity (41.336% ungapped) in 493 aa overlap. Contains Pfam match to entry PF01977 UPF0096, Protein of unknown function. | Conserved hypothetical protein; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). | 0.932 |
SCO4490 | SCO4327 | gene:17762135 | gene:17761972 | SCD69.10, putative decarboxylase, len: 485 aa; similar to SW:Y209_ARCFU (EMBL:AE001091) Archaeoglobus fulgidus hypothetical protein AF0209, 481 aa; fasta scores: opt: 1557 z-score: 1800.8 E(): 0; 48.6% identity in 484 aa overlap and to SW:P26615 (UBID_ECOLI) 3-Octaprenyl-4-hydroxybenzoate carboxy-lyase from Escherichia coli (497 aa) fasta scores; opt: 1293, Z-score: 1478.5, 40.162% identity (41.336% ungapped) in 493 aa overlap. Contains Pfam match to entry PF01977 UPF0096, Protein of unknown function. | Conserved hypothetical protein SCD12A.10c; Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). Does not accept aminodeoxyfutalosine (AFL) as a substrate; Belongs to the PNP/UDP phosphorylase family. Futalosine hydrolase subfamily. | 0.866 |