STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO4609SCD39.09, possible peptidase, len: 287 aa; similar to SW:HTPX_MYCTU (EMBL:Z95558) Mycobacterium tuberculosis probable protease HtpX homolog (EC 3.4.24.-), 286 aa; fasta scores: opt: 1208 z-score: 1421.7 E(): 0; 65.4% identity in 283 aa overlap. Contains Pfam match to entry PF01435 Peptidase_M48, Peptidase family M48 and match to Prosite entry PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. Also contains possible hydrophobic membrane spanning regions; Belongs to the peptidase M48B family. (287 aa)    
Predicted Functional Partners:
SCO4610
SCD39.10, possible integral membrane protein, len: 138 aa; similar to TR:O53882 (EMBL:AL022004) Mycobacterium tuberculosis hypothetical 13.7 kDa protein MTV043.63c, 129 aa; fasta scores: opt: 509 z-score: 623.4 E(): 3e-27; 63.1% identity in 122 aa overlap. Contains possible hydrophobic membrane spanning regions.
       0.875
SCO4611
Hypothetical protein SCD39.11; SCD39.11, unknown, len: 197 aa.
       0.781
SCO4607
SCD39.07, nuoM2, NADH dehydrogenase subunit, len: 534 aa; similar to SW:NUOM_ECOLI (EMBL:X68301) Escherichia coli NADH dehydrogenase I chain M (EC 1.6.5.3) NuoM, 509 aa; fasta scores: opt: 721 z-score: 798.7 E(): 0; 33.9% identity in 528 aa overlap and to TR:Q9XAR6 (EMBL:AL078618) Streptomyces coelicolor SCD16A.09c, NuoM, NADH dehydrogenase subunit, 523 aa; fasta scores: opt: 462 z-score: 441.4 E(): 6e-19; 34.1% identity in 537 aa overlap. Contains Pfam match to entry PF00361 oxidored_q1, NADH-Ubiquinone/plastoquinone (complex I), various chains and possible hydrophobic membrane spanni [...]
     
 0.745
SCO4599
NADH dehydrogenase subunit NuoA2; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.
  
    0.743
SCO4600
NADH dehydrogenase subunit NuoB2; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
       0.739
SCO4601
SCD39.01, possible dehydrogenase, len: 453 aa; N-terminal region similar to SW:NUC1_RHIME (EMBL:AF055637) Rhizobium meliloti NADH dehydrogenase I chain C1 (EC 1.6.5.3) NuoC, 201 aa; blastp scores: Score = 201 (70.8 bits), Expect = 1.7e-15, P = 1.7e-15; Identities = 49/134 (36%), Positives = 69/134 (51%). Contains Pfam match to entry PF00329 complex1_30Kd, Respiratory-chain NADH dehydrogenase, 30 Kd subunit. Contains 2x conserved repeat: PRRSRSASQGSASQR and rich region in alanine, proline and glutamic acid amino acid residues both at C-terminal domain.
       0.739
SCO4602
NADH dehydrogenase subunit NuoH2; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.
       0.739
SCO4603
NADH dehydrogenase subunit NuoI2; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
       0.739
SCO4604
NADH dehydrogenase subunit NuoJ2; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
       0.739
SCO4605
NADH dehydrogenase subunit NuoK2; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 4L family.
       0.739
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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