STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
SCO4643UDP-N-acetylenoylpyruvoylglucosamine reductase; Cell wall formation. (383 aa)    
Predicted Functional Partners:
SCO2949
UDP-N-acetylglucosamine transferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily.
    
 0.996
SCO6060
Putative UDP-N-acetylmuramoyl-L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family.
 
 
 0.994
SCO2084
UDPdiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily.
 
  
 0.975
SCO2089
Putative UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily.
 
  
 0.972
SCO2086
Putative UDP-N-acetylmuramoylalanine-D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family.
 
   
 0.966
SCO5998
Putative UDP-N-acetylglucosamine transferase; SCBAC1C11.01c, murA2, possible bifunctional protein (fragment), len: >138 aa; N-terminal domain similar to TR:Q9X153 (EMBL:AE001787) Thermotoga maritima lacI-family transcriptional regulator, putative TM1330, 111 aa; fasta scores: opt: 139 z-score: 193.0 E(): 0.0033; 39.4% identity in 66 aa overlap. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix and possible helix-turn-helix motif at residues 22..43 (+7.45 SD) and C-terminal domain similar to TR:Q9PJT7 (EMBL:AE002342) Chlamydia muridarum UDP-N-acetylglucosamine 1-carboxyvinylt [...]
 
  
 0.943
SCO2088
Putative UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-D-alanyl-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily.
 
  
 0.937
SCO3595
Putative D-alanine:D-lactate ligase; Required for resistance to glycopeptides antibiotics. D-Ala-- D-Ala ligase of altered specificity which catalyzes ester bond formation between D-Ala and various D-hydroxy acids; producing a peptidoglycan which does not terminate by D-alanine but by D-lactate, thus preventing vancomycin binding (By similarity); Belongs to the D-alanine--D-alanine ligase family.
 
  
 0.890
SCO2087
Putative phospho-N-acetylmuramoyl-pentapeptide-transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily.
 
  
 0.875
SCO4642
Hypothetical protein SCD82.13; SCD82.13, unknown, len: 126 aa.
       0.875
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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