STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Coexpression
Experiments
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Textmining
[Homology]
Score
SCO4906Sensor kinase protein; Forms part of a two-component regulatory system AfsQ1/AfsQ2 involved in secondary metabolism. May activate AfsQ1 by phosphorylation. (535 aa)    
Predicted Functional Partners:
SCO4907
Transcriptional regulatory protein; Forms part of a two-component regulatory system AfsQ1/AfsQ2 involved in secondary metabolism.
 
 
 0.992
SCO3013
SCE33.15c, probable two-component system response regulator, len: 229 aa; similar to TR:Q50447 (EMBL:Z95121) Mycobacterium tuberculosis MtrA, 228 aa; fasta scores: opt: 1141 z-score: 1397.7 E(): 0; 74.9% identity in 227 aa overlap, to SW:AFQ1_STRCO (EMBL:D10654) Streptomyces coelicolor transcriptional regulatory protein AfsQ1, 225 aa; fasta scores: opt: 698 z-score: 858.5 E(): 0; 47.7% identity in 220 aa overlap and to many other S. coelicolor two-component system response regulators, e.g. TR: CAB77324(EMBL:AL160331) putative response regulator SCD8A.03, 223 aa; fasta scores: opt: 695 [...]
 
 0.978
SCO5748
SC7C7.03, probable sensory histidine kinase, len: 1829 aa; N-terminus has 11 92aa repeats. Highly similar to putative osmosensing histidine kinases from yeasts (with only five repeats) e.g. Neurospora crassa TR:Q01318 (EMBL:U53189) osmotic-1 locus putative histidine kinase (1298 aa), fasta scores; opt: 2011 z-score: 1764.6 E(): 0, 38.3% identity in 1281 aa overlap. Also similar to BARA_ECOLI sensor protein BarA (918 aa) (with only one copy of the repeat), fasta scores; opt: 378 z-score: 755.8, E(): 0, 28.9% identity in 619 aa overlap. Extreme N-terminus has similarity to the phosphoryl [...]
 
 
 
0.899
SCO4905
2SCK8.31c, possible lipoprotein, len: 203 aa; similar to TR:Q9K453 (EMBL:AL359215) Streptomyces coelicolor putative secreted protein SC2H12.31, 211 aa; fasta scores: opt: 142 z-score: 175.4 E(): 0.033; 29.3% identity in 205 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence.
     
 0.891
SCO3358
Two-component system response regulator; Member of the two-component regulatory system CseB/CseC involved in the stability of the cell envelope. CseB activates transcription of RNA polymerase sigma-E factor, in response to changes in the cell envelope.
 
 
 0.855
SCO7230
SC2H12.29, possible two-component system response regulator, len: 229 aa. Highly similar to many other putative two-component system regulators e.g. Mycobacterium bovis SW:RGX3_MYCBO (EMBL:Y13627) sensory transduction protein, RegX3 (227 aa), fasta scores opt: 609 z-score: 727.0 E(): 0 44.7% identity in 226 aa overlap and Streptomyces coelicolor TR:CAB90891 (EMBL:AL355753) two-component system response regulator protein, SC8G12.09 (233 aa), fasta scores opt: 953 z-score: 1131.9 E(): 0 63.4% identity in 235 aa overlap. Contains a Pfam match to entry PF00072 response_reg, Response regula [...]
 
 
 0.841
SCO7533
SC8G12.09, two-component system response regulator protein, len: 233 aa. Highly similar to many putative response regulators including: Amycolatopsis mediterranei TR:CAB82846(EMBL:AJ277082) putative response regulator (229 aa), fasta scores opt: 937 z-score: 1114.4 E(): 0 61.9% identity in 231 aa overlap and Streptomyces coelicolor TR:Q9ZEP4(EMBL:AJ131213) response regulator, SCE94.09 (234 aa), fasta scores opt: 665 z-score: 793.6 E():0 45.5% identity in 231 aa overlap. Contains a Pfam match to entry PF00072 response_reg, Response regulator receiver domain and a Pfam match to entry PF0 [...]
 
 
 0.840
SCO5351
SCBAC5H2.20, possible regulatory protein, len: 167 aa; similar to the N-terminal domain of several regulatory proteins, e.g. TR:Q9X6C1 (EMBL:AF135389) Tolypothrix PCC7601 DNA binding response regulator RpaA, 247 aa; fasta scores: opt: 332 z-score: 343.7 E(): 1.4e-11; 42.0% identity in 119 aa overlap. Contains Pfam match to entry PF00072 response_reg, Response regulator receiver domain.
 
 
 0.818
SCO5403
SC8F4.07, probable two-component system response regulator, len: 222 aa; similar to many e.g. SW:Q02540 (COPR_PSESM) CopR transcriptional activator protein from Pseudomonas syringae (pv. tomato) (227 aa) fasta scores; opt: 621, z-score: 735.4, E(): 0, 45.7% identity in 223 aa overlap. Contains a Pfam match to entry PF00072 response_reg, Response regulator receiver domain and Pfam match to entry PF00486 trans_reg_C, Transcriptional regulatory protein, C terminal.
 
 
 0.813
SCO3741
SCH22A.19c, probable response regulator, len: 256 aa; similar to TR:P74922 (EMBL:U67196) Thermotoga maritima DNA-binding response regulator DrrA, 239 aa; fasta scores: opt: 664 z-score: 686.2 E(): 8.4e-31; 45.3% identity in 234 aa overlap and to SW:AFQ1_STRCO (EMBL:D10654) Streptomyces coelicolor transcriptional regulatory protein AfsQ1, 225 aa; fasta scores: opt: 630 z-score: 652.1 E(): 6.7e-29; 47.1% identity in 221 aa overlap. Contains Pfam matches to entries PF00072 response_reg, Response regulator receiver domain and PF00486 trans_reg_C, Transcriptional regulatory protein, C termi [...]
 
 
 0.810
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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