STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
SCO4956Putative peptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. (172 aa)    
Predicted Functional Partners:
SCO6061
SC9B1.08, possible oxidoreductase, len: 135aa; highly conserved in prokaryotes and eukaryotes eg. TR:P71971 (EMBL:Z80225) from Mycobacterium tuberculosis (136 aa) fasta scores; opt: 653, z-score: 835.9, E(): 0, (71.1% identity in 128 aa overlap) and TR:CAB40164 (EMBL:AL049558) from Schizosaccharomyces pombe (138 aa) fasta scores; opt: 475, z-score: 612.0, E(): 9e-27, (48.1% identity in 135 aa overlap). Also similar to SW:PMSR_STRPN Peptide methionine sulfoxide reductase from Streptococcus pneumoniae (312 aa) fasta scores; opt: 331, z-score: 426.0, E(): 2.1e-16, (46.2% identity in 132 a [...]
 
 0.997
SCO1084
SCG22.30c, possible thioredoxin, len: 126 aa; similar to TR:Q50039 (EMBL:U15182) Mycobacterium leprae ThiX, 172 aa; fasta scores: opt: 253 z-score: 318.8 E(): 2.8e-10; 40.6% identity in 101 aa overlap, 172 and to SW:THIO_MYCSM (EMBL:AF023161) Mycobacterium smegmatis thioredoxin TrxA, 112 aa; fasta scores: opt: 147 z-score: 193.6 E(): 0.0026; 28.4% identity in 109 aa overlap. Contains match to Prosite entry PS00194 Thioredoxin family active site.
  
 0.983
SCO5187
2SC3B6.11c, possible glutaredoxin-like protein, len: 80 aa; similar to SW:NRDH_LACLC (EMBL:X92690) Lactococcus lactis glutaredoxin-like protein NrdH, 72 aa; fasta scores: opt: 119 z-score: 176.0 E(): 0.024; 35.6% identity in 59 aa overlap. Contains match to Prosite entry PS00194 Thioredoxin family active site.
  
 
 0.919
SCO2003
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.890
SCO2989
SCE50.17c, possible integral membrane protein, len: 145 aa; similar to TR:Q9X8C2 (EMBL:AL049763) Streptomyces coelicolor hypothetical 13.0 kD protein SCE36.09, 114 aa; fasta scores: opt: 256 z-score: 321.6 E(): 1.8e-10; 53.5% identity in 71 aa overlap. Contains possible N-terminal region signal peptide sequence and possible hydrophobic membrane spanning regions.
  
 
 0.877
SCO3442
Hypothetical protein; SCE36.09, unknown, len: 114aa.
  
 
 0.877
SCO3321
SCE68.19c, possible redoxin, len: 101 aa; similar to TR:O69271 (EMBL:Y09572), NrdH, Corynebacterium ammoniagenes NrdH-redoxin from a ribonucleotide reductase operon (75 aa), fasta scores; opt: 96 z-score: 145.6 E(): 0.88, 27.6% identity in 76 aa overlap. Also similar to SW:YV35_MYCTU (EMBL:Z77162) Mycobacterium tuberculosis hypothetical protein (97 aa) (33.3% identity in 75 aa overlap). Cys32 and Cys35 are conserved in similar proteins.
  
 
 0.781
SCO4967
Conserved hypothetical protein; A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S- conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics; Belongs to the MshB deacetylase family. Mca subfamily.
  
  
 0.755
SCO4770
Inosine 5' monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
  
 0.745
SCO4958
2SCK31.18, metB, cystathionine gamma-synthase, len: 386 aa; highly similar to TR:Q9RQ97 (EMBL:AF126953) Corynebacterium glutamicum cystathionine gamma-synthase MetB, 396 aa; fasta scores: opt: 1497 z-score: 1715.4 E(): 0; 59.2% identity in 377 aa overlap. Contains Pfam match to entry PF01053 Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme and match to Prosite entry PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1.
  
 
 0.672
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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