STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
SCO5083Putative actinorhodin transporter; Promotes the efflux of actinorhodin; Belongs to the major facilitator superfamily. EmrB family. (578 aa)    
Predicted Functional Partners:
SCO5082
SCBAC28G1.08c, actII-1, probable transcriptional regulatory protein, len: 259 aa; identical to previously sequenced TR:Q53901 (EMBL:M64683) Streptomyces coelicolor ORF1-4 (ActII), 259 aa. Contains Pfam matches to entries PF00440 tetR, Bacterial regulatory proteins, tetR family and PF02909 tetR_C, Tetracyclin repressor, C-terminal all-alpha domain and possible helix-turn-helix motif at residues 53..73 (+2.78 SD).
 
   
 0.874
SCO5084
SCBAC28G1.10, actII-3, putative membrane protein, len: 711 aa; identical to previously sequenced SW:MMLA_STRCO (EMBL:M64683) Streptomyces coelicolor putative membrane protein ActII-3, 711 aa. Contains possible hydrophobic membrane spanning regions.
     
 0.861
SCO5085
Actinorhodin cluster activator protein; Transcriptional activator of actinorhodin biosynthetic genes.
     
 0.637
SCO5046
Hypothetical protein; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA.
      
 0.483
SCO2937
SCE56.01c, possible transport protein (partial), len: >170 aa; similar to TR:AAF11647 (EMBL:AE002045) Deinococcus radiodurans conserved hypothetical protein DR2098, 462 aa; fasta scores: opt: 330 z-score: 380.0 E(): 9.3e-14; 37.4% identity in 155 aa overlap and to TR:O69070 (EMBL:AF079900) Streptomyces rimosus tetracycline efflux protein OtrB, 563 aa; fasta scores: opt: 271 z-score: 312.6 E(): 5.3e-10; 34.8% identity in 158 aa overlap. Contains possible hydrophobic membrane spanning regions; SCE19A.37c, possible transmembrane transport protein, partial CDS, len: >344 aa; weak similarit [...]
  
     0.466
SCO5078
SCBAC28G1.04, actVA3, hypothetical protein, len: 281 aa; identical to previously sequenced TR:Q53905 (EMBL:X58833) Streptomyces coelicolor 6 ActVA region genes of the actinorhodin biosynthetic gene cluster, ActVA3, 281 aa.
      
 0.416
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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