STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
SCO5089Actinorhodin polyketide synthase acyl carrier protein; Acyl carrier protein. (86 aa)    
Predicted Functional Partners:
SCO5088
SCBAC28G1.14, actIORF2, actinorhodin polyketide beta-ketoacyl synthase beta subunit (also known as chain length factor), len: 407 aa; identical to previously sequenced SW:KASB_STRCO (EMBL:X63449) Streptomyces coelicolor actinorhodin polyketide putative beta-ketoacyl synthase 2 ActI ORF2, 407 aa. Contains Pfam matches to entries PF00109 ketoacyl-synt, Beta-ketoacyl synthase, N-terminal domain and PF02801 ketoacyl-synt_C, Beta-ketoacyl synthase, C-terminal domain.
 
 0.997
SCO5087
SCBAC28G1.13, actIORF1, actinorhodin polyketide beta-ketoacyl synthase alpha subunit, len: 467 aa; identical to C-terminal region of SW:KASA_STRCO (EMBL:X63449) Streptomyces coelicolor actinorhodin polyketide putative beta-ketoacyl synthase 1 ActI ORF1, 424 aa. Previously sequenced start codon at residue 44 of this sequence. Also similar to TR:CAB45606 (EMBL:AL079356) Streptomyces coelicolor polyketide beta-ketoacyl synthase alpha (WhiE locus) SC6G9.15, 424 aa; fasta scores: opt: 1706 Z-score: 1660.2 bits: 316.4 E(): 9.5e-87; 61.871% identity in 417 aa overlap. Contains Pfam matches to [...]
 
 0.996
SCO5086
SCBAC28G1.12c, actIII, ketoacyl reductase, len: 261 aa; identical to previously sequenced SW:ACT3_STRCO (EMBL:M19536) Streptomyces coelicolor putative ketoacyl reductase ActIII, 261 aa. Contains Pfam matches to entries PF00106 adh_short, short chain dehydrogenase and PF00678 adh_short_C2, Short chain dehydrogenase/reductase C-terminus and match to Prosite entry PS00061 Short-chain dehydrogenases/reductases family signature; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
 
 0.990
SCO6560
SC4B5.10c, respiratory chain oxidoreductase, len: 646 aa; C-terminal region is similar to the N-terminal region of many proteins involved in electron transfer e.g. TR:O27592 (EMBL:AE000915) NADP-reducing hydrogenase, subunit C from Methanobacterium thermoautotrophicum (630 aa), fasta scores; opt: 121,4 z-score: 1170.7, E(): 0, (47.1% identity in 397 aa overlap). Contains PS00645 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2.
  
 0.986
SCO5090
Actinorhodin polyketide synthase bifunctional cyclase/dehydratase; Is needed for correct cyclization of the oligoketide leading to isochromanequinone formation.
 
   
 0.983
SCO6431
SC1A6.20, probable peptide synthase, len: 1171 aa; similar to many e.g. TR:Q44103 (EMBL:X97860) Amycolatopsis mediterranei aps gene for peptide synthetase (1324 aa), fasta scores; opt: 379 z-score: 1175.7 E(): 0, 32.3% identity in 993 aa overlap. Contains PS00455 Putative AMP-binding domain signature, PS00012 Phosphopantetheine attachment site and Pfam match to entry AMP-binding PF00501, AMP-binding enzymes, score 421.02.
  
 
 0.923
SCO5091
Cyclase; SCBAC28G1.17, actIV, cyclase, len: 297 aa; identical to previously sequenced TR:Q02057 (EMBL:X63449) Streptomyces coelicolor dehydrogenase ActI ORF5, 297 aa. Contains Pfam match to entry PF00753 lactamase_B, Metallo-beta-lactamase superfamily.
   
 
 0.920
SCO1272
2SCG18.19c, probable acyl carrier protein, len: 90 aa; similar to SW:ACPA_STRCO (EMBL:X63449) Streptomyces coelicolor actinorhodin polyketide synthase acyl carrier protein (ActI-ORF3), 86 aa; fasta scores: opt: 189 z-score: 253.9 E(): 1.2e-06; 40.2% identity in 82 aa overlap. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site and match to Prosite entry PS00012 Phosphopantetheine attachment site.
  
  
 
0.914
SCO0127
SCJ21.08, probable multi-domain beta keto-acyl synthase, len: 2240 aa; similar to proteins involved in fatty acid or polyketide biosynthesis e.g. TR:Q44221 Anabaena sp. type 4 polyketide synthases HglD (fragment) (448 aa), fasta scores; opt: 760 z-score: 639.3 E(): 2.9e-28, 38.0% identity in 392 aa overlap; MCAS_MYCBO mycocerosic acid synthase (2110 aa), fasta scores opt: 707 z-score: 586.8 E(): 2.5e-25, 35.4% identity in 560 aa overlap; and TR:O54142 (EMBL:AL021530) S. coelicolor polyketide synthase RedX (982 aa), opt: 658 z-score: 550.3 E(): 2.7e-23, 36.4% identity in 470 aa overlap. [...]
  
 
 0.867
SCO5092
SCBAC28G1.18, actVB, actinorhodin polyketide possible dimerase, len: 177 aa; identical to previously sequenced SW:DIM6_STRCO (EMBL:X63449) Streptomyces coelicolor actinorhodin polyketide dimerase ActI ORF6, ActVB, 177 aa Contains Pfam match to entry PF01613 Flavin_Reduct, Flavin reductase like domain.
     
 0.852
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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