STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
SCO5356Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (309 aa)    
Predicted Functional Partners:
SCO5354
SCBAC5H2.23, thrA, homoserine dehydrogenase, len: 429 aa; highly similar to SW:DHOM_CORGL (EMBL:Y00546) Corynebacterium glutamicum homoserine dehydrogenase (EC 1.1.1.3) Hom or ThrA, 445 aa; fasta scores: opt: 1592 z-score: 1742.3 E(): 0; 57.7% identity in 423 aa overlap. Contains Pfam matches to entries PF00742 Homoserine_dh, Homoserine dehydrogenase and PF01842 ACT, ACT domain and match to Prosite entry PS01042 Homoserine dehydrogenase signature. Note: Can participate in the biosynthesis of Methionine, Lysine and Threonine (plus following steps to Valine, Leucine and Isoleucine).
  
 0.998
SCO5355
Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.
 
 
 0.998
SCO0420
SCF51.19c, possible homoserine dehydrogenase, len: 344 aa; similar to SW:DHOM_SYNY3 (EMBL:D64001) Synechocystis sp. (strain PCC 6803) homoserine dehydrogenase (EC 1.1.1.3) (HDH), 433 aa; fasta scores: opt: 284 z-score: 307.6 E(): 9.2e-10; 29.0% identity in 335 aa overlap and to TR:O26517 (EMBL:AE000826) Methanobacterium thermoautotrophicum homoserine dehydrogenase homologue MTH417, 340 aa; fasta scores: opt: 332 z-score: 359.9 E(): 1.1e-12; 30.1% identity in 335 aa overlap. Contains Prosite match to entry PS01042 Homoserine dehydrogenase signature.
 
 0.997
SCO4293
SCD95A.26, probable threonine synthase, len: 428 aa; similar to TR:P73711 (EMBL:D90908) Synechocystis sp. threonine synthase ThrC, 433 aa; fasta scores: opt: 1467 z-score: 1612.7 E(): 0; 55.0% identity in 422 aa overlap. Contains Pfam match to entry PF00291 S_T_dehydratase, Pyridoxal-phosphate dependent enzyme.
 
 
 0.986
SCO0985
Putative methionine synthase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
  
 
 0.930
SCO1657
Putative methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
    
 0.922
SCO4087
SCD25.23, purM, phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1), len: 355 aa. Identical to Streptomyces lividans TR:Q9ZB03 (EMBL:U64826) phosphoribosyl aminoimidazole synthetase (EC 6.3.3.1) (355 aa), fasta scores opt: 2313 z-score: 2645.5 E(): 0; 100.0% identity in 355 aa overlap and highly similar to many others e.g. Escherichia coli SW:PUR5_ECOLI (EMBL:M13747) phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIRS) (phosphoribosyl-aminoimidazole synthetase) (AIR synthase) (344 aa), fasta scores opt: 1018 z-score: 1167.8 E(): 0; 48.4% identity in 343 aa overlap [...]
 
    
 0.907
SCO5353
Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine.
 
  
 0.887
SCO3615
SC66T3.26c, ask, probable aspartokinase, len: 425 aa; highly similar to many e.g. SW:AKAB_MYCSM (EMBL:Z17372), ask, Mycobacterium smegmatis aspartokinase (421 aa), fasta scores; opt: 1839 z-score: 1990.8 E(): 0, 67.4% identity in 427 aa overlap. Homologous genes encode both the alpha and beta subunits of ask by using alternative initiation codons. Codon 253 represents the equivalent position in this sequence, by similarity. Contains Pfam match to entry PF00696 aakinase, Aspartate kinases, Glutamate kinases and Gamma glutamate phospho-reductases and PS00324 Aspartokinase signature.
  
 
 0.880
SCO5739
Putative dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
 
  
 0.858
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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