STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO5388Conserved hypothetical protein; Cleaves both 3' and 5' ssDNA extremities of branched DNA structures; Belongs to the NucS endonuclease family. (251 aa)    
Predicted Functional Partners:
SCO3878
DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]
  
 
 
 0.795
dnaE
SCP1.224c, dnaE, probable DNA polymerase III, alpha chain (EC 2.7.7.7), len: 1213aa; similar to many eg. SW:Q10779 (DP3A_MYCTU) probable DNA polymerase III, alpha chain from Mycobacterium tuberculosis (1184 aa) fasta scores; opt: 3067, z-score: 3382.7, E(): 0, 55.8% identity in 1200 aa overlap and SW:P10443 (DP3A_ECOLI) DNA polymerase III, alpha chain (EC 2.7.7.7) from Escherichia coli (1160 aa) fasta scores; opt: 845, z-score: 927.5, E(): 0, 36.2% identity in 1178 aa overlap. Contains Pfam match to entry PF02231 PHP_N, PHP domain N-terminal region.
      
 0.783
SCO5389
Hypothetical protein 2SC6G5.33; 2SC6G5.33, unknown, len: 130 aa.
       0.769
SCO5240
Hypothetical protein; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA.
  
     0.753
SCO7106
Conserved hypothetical protein; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA.
  
     0.753
SCP1.95
Putative regulatory protein; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA.
  
     0.748
SCO7306
Regulatory protein; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA.
  
     0.746
SCO1381
SC1A8A.01c, partial CDS, hypothetical protein, len: >183aa; similar to SW:Q50603 (Y0DD_MYCTU) hypothetical protein from Mycobacterium tuberculosis (225 aa) fasta scores; opt: 641, z-score: 633.8, E(): 7.1e-28, 64.7% identity in 150 aa overlap. Note possible alternative translational start sites downstream; SC10A9.23c, conserved hypothetical protein (fragment), len: >78 aa; similar to SW:YI30_MYCTU (EMBL:Z78020) Mycobacterium tuberculosis hypothetical 24.0 kDa protein MTCY1A11.13c, 225 aa; fasta scores: opt: 269 z-score: 377.2 E(): 1.4e-13; 56.0% identity in 75 aa overlap.
  
     0.742
SCO6715
Putative transcriptional regulator; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA.
  
     0.739
SCO5055
Putative exoribonuclease; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family.
  
   
 0.737
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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