STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
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Experiments
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[Homology]
Score
SCO5424Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (407 aa)    
Predicted Functional Partners:
SCO5425
Phosphate acetyltransferase (fragment); Involved in acetate metabolism; In the N-terminal section; belongs to the CobB/CobQ family.
 
 
 0.999
SCO6195
SC2G5.16, probable acetyl-coenzyme A synthetase, len:558 aa; similar to many e.g. SW:ACSA_BACSU from Bacillus subtilis (572 aa) fasta scores; opt: 798, z-score: 878.3,E():0, (31.8% identity in 537 aa overlap). Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme, score 116.90, E-value 3.8e-31. Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme, score 116.90, E-value 3.8e-31.
   
 
 0.991
SCO3563
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
   
 
 0.990
SCO0982
SCBAC19F3.09, aceA, isocitrate lyase, len: 426 aa: strongly similar to many e.g. SW:O53752 (ACEA_MYCTU) isocitrate lyase from Mycobacterium tuberculosis (428 aa) fasta scores; opt: 2144, Z-score: 2405.5, 74.822% identity (75.000% ungapped) in 421 aa overlap. Contains Pfam matches to entry PF00463 ICL, Isocitrate lyase family and Prosite match to PS00161 Isocitrate lyase signature.
   
  
 0.960
SCO0617
SCF56.01c, hypothetical protein (partial CDS), len: >634 aa; similar to various hypothetical proteins, e.g. TR:P74690 (EMBL:D90917) Synechocystis sp. hypothetical 92.4 kD protein, 821 aa; fasta scores: opt: 2107 z-score: 2288.7 E(): 0; 58.1% identity in 513 aa overlap; SCF55.41c, hypothetical protein, len: 210 aa; similar to various hypothetical proteins, e.g. TR:P74690 (EMBL:D90917) Synechocystis sp. (strain PCC 6803) hypothetical 92.4 KD protein, 821 aa; fasta scores: opt: 1405 z-score: 1694.1 E(): 0; 56.1% identity in 328 aa overlap.
 
 0.956
SCO6155
SC1A9.19, poxB, pyruvate oxidase, len: 580aa; similar to many including POXB_ECOLI (EMBL:X04105) PoxB, pyruvate oxidase from Escherichia coli (572 aa) fasta scores; opt:2086, z-score: 2458.4, E():0, (53.1% identity in 571 aa overlap). Contains Pfam match to entry PF00205 TPP_enzymes, Thiamine pyrophosphate enzymes, score 499.70, E-value 2.4e-154.
    
 0.945
SCO7412
SC6D11.08, possible pyruvate dehydrogenase (pyruvate oxidase), len: 600 aa. Highly similar to many including: Escherichia coli SW:POXB_ECOLI(EMBL:X04105) pyruvate dehydrogenase (572 aa), fasta scores opt: 770 z-score: 855.7 E(): 0 34.6% identity in 566 aa overlap and Streptomyces coelicolor TR:Q9ZBT3(EMBL:AL034446) pyruvate dehydrogenase (pyruvate oxidase), SC1A9.19 (580 aa), fasta scores opt: 866 z-score: 962.2 E():0 33.1% identity in 556 aa overlap. Contains a Pfam match to entry PF00205 TPP_enzymes, Thiamine pyrophosphate enzymes. Also contains a Prosite hit to PS00187 Thiamine pyro [...]
    
 0.945
SCO1706
SCI30A.27c, probable aldehyde dehydrogenase, len: 462 aa; similar to many e.g. TR:O33455 (EMBL:U24215) P-cumic aldehyde dehydrogenase from Pseudomonas putida Fl (494 aa) fasta scores; opt: 1109, z-score: 1142.8, E(): 0, (44.6% identity in 471 aa overlap) and TR:O88069 (EMBL:AL031541) putative aldehyde dehydrogenase from Streptomyces coelicolor (483 aa) fasta scores; opt: 1011, z-score: 1042.5, E(): 0, (41.8% identity in 466 aa overlap). Contains Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase and Prosite match to PS00687 Aldehyde dehydrogenases glutamic acid active site.
  
 
 0.939
SCO3420
SCE9.27c, probable aldehyde dehydrogenase, len: 486 aa; highly similar to many NAD-linked aldehyde dehydrogenases e.g. SW:XYLC_PSEPU (EMBL:U15151), xylC, Pseudomonas putida benzaldehyde dehydrogenase [NAD+] from TOL plasmid pWW0 (487 aa), fasta scores; opt: 1244 z-score: 1420.3 E(): 0, 41.5% identity in 479 aa overlap. Similar to others from S.coelicolor e.g. TR:O88069 (EMBL:AL031541) probable aldehyde dehydrogenase (483 aa) (40.0% identity in 448 aa overlap). Contains Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase, score 491.30, E-value 7.6e-144, PS00687 Aldehyde dehydroge [...]
  
 
 0.939
SCO1174
SCG11A.05, thcA, aldehyde dehydrogenase, len:534 aa; highly similar to SW:THCA_RHOSN (EMBL:U17129) Rhodococcus sp. (strain NI86/21) EPTC-inducible aldehyde dehydrogenase (EC 1.2.1.3) ThcA, 505 aa; fasta scores: opt: 2639 z-score: 3078.6 E(): 0; 75.7% identity in 506 aa overlap. Contains Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase and two matches to Prostie entries PS00687 Aldehyde dehydrogenases glutamic acid active site and PS00070 Aldehyde dehydrogenases cysteine active site.
  
 
 0.938
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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