STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
SCO5488tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (376 aa)    
Predicted Functional Partners:
SCO5486
SC2A11.20, probable pyridoxal-phosphate-dependent aminotransferase, len: 389 aa; similar to many e.g. NIFS_ANASP Anaebaena NifS protein (400 aa), fasta scores; opt: 855 z-score: 1070.8 E(): 0, 40.4% identity in 384 aa overlap and SPL1_CANAL Candida albicans tRNA splicing protein SPL1 (488 aa), fasta scores; opt: 791 z-score: 912.8 E(): 0, 36.6% identity in 388 aa overlap. Contains Pfam match to entry PF00266 aminotran_5, Aminotransferases class-V, score 259.00, E-value 6.2e-74.
 
  
 0.824
SCO2157
SC6G10.30, probable aminotransferase, len: 460 aa; similar to many NifS-like proteins e.g. SW:NIFS_RHOSH NifS protein from Rhodobacter sphaeroides (387 aa) fasta scores; opt: 702, z-score: 760.5, E(): 0, (37.4% identity in 390 aa overlap). Contains Pfam matches to entry PF00266 aminotran_5, Aminotransferases class-V and entry PF01206 UPF0033, Uncharacterized protein family UPF0033; Belongs to the sulfur carrier protein TusA family.
 
  
 0.810
SCO2445
SCC24.16, probable acetyl CoA carboxylase (alpha and beta subunits), len: 458 aa; N-terminal region similar to SW:ACCD_ECOLI (EMBL:M32445) Escherichia coli acetyl-Coenzyme A carboxylase carboxyl transferase subunit beta (EC 6.4.1.2) AccD, 304 aa; fasta scores: opt: 368 z-score: 366.2 E(): 5.8e-13; 32.4% identity in 238 aa overlap and C-terminal region similar to TR:AAF10787 (EMBL:AE001970) Deinococcus radiodurans acetyl-CoA carboxylase carboxyl transferase alpha subunit DR1214, 316 aa; fasta scores: opt: 366 z-score: 364.0 E(): 7.7e-13; 39.9% identity in 223 aa overlap.
  
    0.764
SCO1594
SCI35.16c, pheT, proabable phenylalanyl-tRNA synthetase beta chain, len: 840 aa; similar to many e.g. SYFB_ECOLI phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) (795 aa), fasta scores; opt: 988 z-score: 1290.9 E(): 0, 36.0% identity in 849 aa overlap. Contains PS00017 ATP/GTP-binding.
 
  
 0.727
SCO4115
Putative secreted protein; SCD72A.01, unknown, partial CDS, len: >590 aa; SCD17A.07, possible secreted protein (fragment), len: >151 aa. Contains possible and cleavable N-terminal region signal peptide sequence.
      
 0.681
SCO1472
SCL6.29c, conserved hypothetical Sun-family protein, len: 475 aa; similar to SW:SUN_BACSU (EMBL:Y13937) Bacillus subtilis sun protein, 447 aa; fasta scores: opt: 637 z-score: 711.7 E(): 3.2e-32; 32.0% identity in 472 aa overlap. Contains Pfam match to entry PF01029 NusB, NusB family and to entry PF01189 Nol1_Nop2_Sun, NOL1/NOP2/sun family and match to Prosite entry PS01153 NOL1/NOP2/sun family signature; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
  
  
 0.643
SCO5487
Conserved hypothetical protein SC2A11.21c; SC2A11.21c, unknown, len: 242 aa; some similarity in C-terminus to enterobacterial ampD genes e.g. AMPD_ECOLI AMPD protein (183 aa), fasta scores; opt: 210 z-score: 212.6 E(): 0.00014, 31.5% identity in 149 aa overlapand Enterobacter cloacae TR:Q46957 (EMBL:U40785) anhydro-n-acetylmuramyl-tripeptide amidase (187 aa), fasta scores; opt: 207 z-score: 192.0 E(): 0.0019, 31.6% identity in 155 aa overlap.
       0.634
SCO2688
Riboflavin-specific deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
  
  
 0.590
SCO4106
SCD17.10, possible bifunctional enzyme deaminase/reductase, len: 376 aa. Similar to both domains of the Escherichia coli bifunctional SW:RIBD_ECOLI (EMBL; X64395) riboflavin biosynthesis protein RibD (367 aa). However the N-terminal domain of SCD17.10 is similar to the E. coli C-terminal reductase domain, fasta scores opt: 209 z-score: 241.1 E(): 4.5e-06 27.0% identity in 222 aa overlap and the C-terminal domain of SCD17.10 is similar to the E. coli N-terminal deaminase domain (blast scores Expect = 3.2e-07, P = 3.2e-07, Identities = 51/192 (26%), Positives = 77/192 (40%)). Also simila [...]
  
  
 0.590
SCO1473
methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family.
 
  
 0.579
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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