node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SCO1176 | SCO2528 | gene:17758759 | gene:17760130 | SCG11A.07c, probable dihydroxy-acid dehydratase,len: 596 aa; highly similar to TR:CAB46389 (EMBL:AL096743) Streptomyces coelicolor putative dihydroxy-acid dehydratase IlvD, 576 aa; fasta scores opt: 1203 z-score: 1368.5 E(): 0; 53.2% identity in 583 aa overlap and to SW:ILVD_BACSU (EMB:L77246) Bacillus subtilis dihydroxy-acid dehydratase (EC 4.2.1.9) (Dad) (vegetative protein 110) (VEG110) 557 aa; fasta scores: opt: 695 z-score: 790.6 E(): 0; 35.9% identity in 571 aa overlap. Contains match to Pfam entry PF00920 ILVD_EDD, Dehydratase family and match to Prosite entry PS00886 Dihydroxy- [...] | 2-ispoprylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.871 |
SCO1176 | SCO5513 | gene:17758759 | gene:17763165 | SCG11A.07c, probable dihydroxy-acid dehydratase,len: 596 aa; highly similar to TR:CAB46389 (EMBL:AL096743) Streptomyces coelicolor putative dihydroxy-acid dehydratase IlvD, 576 aa; fasta scores opt: 1203 z-score: 1368.5 E(): 0; 53.2% identity in 583 aa overlap and to SW:ILVD_BACSU (EMB:L77246) Bacillus subtilis dihydroxy-acid dehydratase (EC 4.2.1.9) (Dad) (vegetative protein 110) (VEG110) 557 aa; fasta scores: opt: 695 z-score: 790.6 E(): 0; 35.9% identity in 571 aa overlap. Contains match to Pfam entry PF00920 ILVD_EDD, Dehydratase family and match to Prosite entry PS00886 Dihydroxy- [...] | SC8D9.25, ilvN, acetolactate synthase small subunit, len: 174 aa; high level of similarity to many e.g. TR:Q59817 (EMBL:L39268) IlvN, acetolactate synthase small subunit from the ilvBNC gene cluster of Streptomyces avermitilis (176 aa) fasta scores; opt: 884, z-score: 1056.9, E(): 0, (86.4% identity in 176 aa overlap). | 0.919 |
SCO1176 | SCO5514 | gene:17758759 | gene:17763166 | SCG11A.07c, probable dihydroxy-acid dehydratase,len: 596 aa; highly similar to TR:CAB46389 (EMBL:AL096743) Streptomyces coelicolor putative dihydroxy-acid dehydratase IlvD, 576 aa; fasta scores opt: 1203 z-score: 1368.5 E(): 0; 53.2% identity in 583 aa overlap and to SW:ILVD_BACSU (EMB:L77246) Bacillus subtilis dihydroxy-acid dehydratase (EC 4.2.1.9) (Dad) (vegetative protein 110) (VEG110) 557 aa; fasta scores: opt: 695 z-score: 790.6 E(): 0; 35.9% identity in 571 aa overlap. Contains match to Pfam entry PF00920 ILVD_EDD, Dehydratase family and match to Prosite entry PS00886 Dihydroxy- [...] | Acetolactate synthase small subunit; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.978 |
SCO1176 | SCO5522 | gene:17758759 | gene:17763174 | SCG11A.07c, probable dihydroxy-acid dehydratase,len: 596 aa; highly similar to TR:CAB46389 (EMBL:AL096743) Streptomyces coelicolor putative dihydroxy-acid dehydratase IlvD, 576 aa; fasta scores opt: 1203 z-score: 1368.5 E(): 0; 53.2% identity in 583 aa overlap and to SW:ILVD_BACSU (EMB:L77246) Bacillus subtilis dihydroxy-acid dehydratase (EC 4.2.1.9) (Dad) (vegetative protein 110) (VEG110) 557 aa; fasta scores: opt: 695 z-score: 790.6 E(): 0; 35.9% identity in 571 aa overlap. Contains match to Pfam entry PF00920 ILVD_EDD, Dehydratase family and match to Prosite entry PS00886 Dihydroxy- [...] | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.937 |
SCO1176 | SCO5529 | gene:17758759 | gene:17763181 | SCG11A.07c, probable dihydroxy-acid dehydratase,len: 596 aa; highly similar to TR:CAB46389 (EMBL:AL096743) Streptomyces coelicolor putative dihydroxy-acid dehydratase IlvD, 576 aa; fasta scores opt: 1203 z-score: 1368.5 E(): 0; 53.2% identity in 583 aa overlap and to SW:ILVD_BACSU (EMB:L77246) Bacillus subtilis dihydroxy-acid dehydratase (EC 4.2.1.9) (Dad) (vegetative protein 110) (VEG110) 557 aa; fasta scores: opt: 695 z-score: 790.6 E(): 0; 35.9% identity in 571 aa overlap. Contains match to Pfam entry PF00920 ILVD_EDD, Dehydratase family and match to Prosite entry PS00886 Dihydroxy- [...] | Putative 2-isopropylmalate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate. | 0.826 |
SCO1176 | SCO5553 | gene:17758759 | gene:17763210 | SCG11A.07c, probable dihydroxy-acid dehydratase,len: 596 aa; highly similar to TR:CAB46389 (EMBL:AL096743) Streptomyces coelicolor putative dihydroxy-acid dehydratase IlvD, 576 aa; fasta scores opt: 1203 z-score: 1368.5 E(): 0; 53.2% identity in 583 aa overlap and to SW:ILVD_BACSU (EMB:L77246) Bacillus subtilis dihydroxy-acid dehydratase (EC 4.2.1.9) (Dad) (vegetative protein 110) (VEG110) 557 aa; fasta scores: opt: 695 z-score: 790.6 E(): 0; 35.9% identity in 571 aa overlap. Contains match to Pfam entry PF00920 ILVD_EDD, Dehydratase family and match to Prosite entry PS00886 Dihydroxy- [...] | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.926 |
SCO1176 | SCO5554 | gene:17758759 | gene:17763211 | SCG11A.07c, probable dihydroxy-acid dehydratase,len: 596 aa; highly similar to TR:CAB46389 (EMBL:AL096743) Streptomyces coelicolor putative dihydroxy-acid dehydratase IlvD, 576 aa; fasta scores opt: 1203 z-score: 1368.5 E(): 0; 53.2% identity in 583 aa overlap and to SW:ILVD_BACSU (EMB:L77246) Bacillus subtilis dihydroxy-acid dehydratase (EC 4.2.1.9) (Dad) (vegetative protein 110) (VEG110) 557 aa; fasta scores: opt: 695 z-score: 790.6 E(): 0; 35.9% identity in 571 aa overlap. Contains match to Pfam entry PF00920 ILVD_EDD, Dehydratase family and match to Prosite entry PS00886 Dihydroxy- [...] | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.916 |
SCO1176 | SCO7154 | gene:17758759 | gene:17764814 | SCG11A.07c, probable dihydroxy-acid dehydratase,len: 596 aa; highly similar to TR:CAB46389 (EMBL:AL096743) Streptomyces coelicolor putative dihydroxy-acid dehydratase IlvD, 576 aa; fasta scores opt: 1203 z-score: 1368.5 E(): 0; 53.2% identity in 583 aa overlap and to SW:ILVD_BACSU (EMB:L77246) Bacillus subtilis dihydroxy-acid dehydratase (EC 4.2.1.9) (Dad) (vegetative protein 110) (VEG110) 557 aa; fasta scores: opt: 695 z-score: 790.6 E(): 0; 35.9% identity in 571 aa overlap. Contains match to Pfam entry PF00920 ILVD_EDD, Dehydratase family and match to Prosite entry PS00886 Dihydroxy- [...] | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.985 |
SCO1176 | SCO7412 | gene:17758759 | gene:17765072 | SCG11A.07c, probable dihydroxy-acid dehydratase,len: 596 aa; highly similar to TR:CAB46389 (EMBL:AL096743) Streptomyces coelicolor putative dihydroxy-acid dehydratase IlvD, 576 aa; fasta scores opt: 1203 z-score: 1368.5 E(): 0; 53.2% identity in 583 aa overlap and to SW:ILVD_BACSU (EMB:L77246) Bacillus subtilis dihydroxy-acid dehydratase (EC 4.2.1.9) (Dad) (vegetative protein 110) (VEG110) 557 aa; fasta scores: opt: 695 z-score: 790.6 E(): 0; 35.9% identity in 571 aa overlap. Contains match to Pfam entry PF00920 ILVD_EDD, Dehydratase family and match to Prosite entry PS00886 Dihydroxy- [...] | SC6D11.08, possible pyruvate dehydrogenase (pyruvate oxidase), len: 600 aa. Highly similar to many including: Escherichia coli SW:POXB_ECOLI(EMBL:X04105) pyruvate dehydrogenase (572 aa), fasta scores opt: 770 z-score: 855.7 E(): 0 34.6% identity in 566 aa overlap and Streptomyces coelicolor TR:Q9ZBT3(EMBL:AL034446) pyruvate dehydrogenase (pyruvate oxidase), SC1A9.19 (580 aa), fasta scores opt: 866 z-score: 962.2 E():0 33.1% identity in 556 aa overlap. Contains a Pfam match to entry PF00205 TPP_enzymes, Thiamine pyrophosphate enzymes. Also contains a Prosite hit to PS00187 Thiamine pyro [...] | 0.678 |
SCO2528 | SCO1176 | gene:17760130 | gene:17758759 | 2-ispoprylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | SCG11A.07c, probable dihydroxy-acid dehydratase,len: 596 aa; highly similar to TR:CAB46389 (EMBL:AL096743) Streptomyces coelicolor putative dihydroxy-acid dehydratase IlvD, 576 aa; fasta scores opt: 1203 z-score: 1368.5 E(): 0; 53.2% identity in 583 aa overlap and to SW:ILVD_BACSU (EMB:L77246) Bacillus subtilis dihydroxy-acid dehydratase (EC 4.2.1.9) (Dad) (vegetative protein 110) (VEG110) 557 aa; fasta scores: opt: 695 z-score: 790.6 E(): 0; 35.9% identity in 571 aa overlap. Contains match to Pfam entry PF00920 ILVD_EDD, Dehydratase family and match to Prosite entry PS00886 Dihydroxy- [...] | 0.871 |
SCO2528 | SCO3345 | gene:17760130 | gene:17760967 | 2-ispoprylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | SCE7.12c, ilvD, dihydroxy acid dehydratase, len: 617aa; previously sequenced therefore almost (conflict of 3 amino acids) identical to TR:O69198 (EMBL:AF068843) ilvD, dihydroxy acid dehydratase from Streptomyces coelicolor (617 aa) fasta scores; opt: 4019, z-score: 4363.1, E(): 0, (99.2% identity in 617 aa overlap). Also similar to SW:ILVD_ECOLI ilvD, dihydroxy acid dehydratase from Escherichia coli (605 aa) fasta scores; opt: 2644, z-score: 2871.0, E(): 0, (66.5% identity in 606 aa overlap). Contains Pfam match to entry PF00920 ILVD_EDD, Dehydratase family and Prosite matches to PS008 [...] | 0.992 |
SCO2528 | SCO5513 | gene:17760130 | gene:17763165 | 2-ispoprylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | SC8D9.25, ilvN, acetolactate synthase small subunit, len: 174 aa; high level of similarity to many e.g. TR:Q59817 (EMBL:L39268) IlvN, acetolactate synthase small subunit from the ilvBNC gene cluster of Streptomyces avermitilis (176 aa) fasta scores; opt: 884, z-score: 1056.9, E(): 0, (86.4% identity in 176 aa overlap). | 0.987 |
SCO2528 | SCO5514 | gene:17760130 | gene:17763166 | 2-ispoprylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | Acetolactate synthase small subunit; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.967 |
SCO2528 | SCO5522 | gene:17760130 | gene:17763174 | 2-ispoprylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.977 |
SCO2528 | SCO5529 | gene:17760130 | gene:17763181 | 2-ispoprylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | Putative 2-isopropylmalate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate. | 0.904 |
SCO2528 | SCO5553 | gene:17760130 | gene:17763210 | 2-ispoprylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.998 |
SCO2528 | SCO5554 | gene:17760130 | gene:17763211 | 2-ispoprylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.995 |
SCO2528 | SCO7154 | gene:17760130 | gene:17764814 | 2-ispoprylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.909 |
SCO2528 | SCO7412 | gene:17760130 | gene:17765072 | 2-ispoprylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | SC6D11.08, possible pyruvate dehydrogenase (pyruvate oxidase), len: 600 aa. Highly similar to many including: Escherichia coli SW:POXB_ECOLI(EMBL:X04105) pyruvate dehydrogenase (572 aa), fasta scores opt: 770 z-score: 855.7 E(): 0 34.6% identity in 566 aa overlap and Streptomyces coelicolor TR:Q9ZBT3(EMBL:AL034446) pyruvate dehydrogenase (pyruvate oxidase), SC1A9.19 (580 aa), fasta scores opt: 866 z-score: 962.2 E():0 33.1% identity in 556 aa overlap. Contains a Pfam match to entry PF00205 TPP_enzymes, Thiamine pyrophosphate enzymes. Also contains a Prosite hit to PS00187 Thiamine pyro [...] | 0.862 |
SCO3345 | SCO2528 | gene:17760967 | gene:17760130 | SCE7.12c, ilvD, dihydroxy acid dehydratase, len: 617aa; previously sequenced therefore almost (conflict of 3 amino acids) identical to TR:O69198 (EMBL:AF068843) ilvD, dihydroxy acid dehydratase from Streptomyces coelicolor (617 aa) fasta scores; opt: 4019, z-score: 4363.1, E(): 0, (99.2% identity in 617 aa overlap). Also similar to SW:ILVD_ECOLI ilvD, dihydroxy acid dehydratase from Escherichia coli (605 aa) fasta scores; opt: 2644, z-score: 2871.0, E(): 0, (66.5% identity in 606 aa overlap). Contains Pfam match to entry PF00920 ILVD_EDD, Dehydratase family and Prosite matches to PS008 [...] | 2-ispoprylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.992 |