STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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SCO5804Conserved hypothetical protein SC4H2.25; Negatively regulates transcription of nrdRJ (class II RNR genes) and nrdABS operon (class I RNR genes) by binding to NrdR-boxes which are proximal to or overlap with the promoter regions of class II and class Ia RNR operons, respectively. (182 aa)    
Predicted Functional Partners:
SCO5805
Ribonucleotide reductase; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen; Belongs to the ribonucleoside diphosphate reductase class-2 family.
     
 0.980
SCO5225
Ribonucleotide-diphosphate reductase small chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family.
     
 0.856
SCO1849
Cobalamin biosynthesis protein; SCI8.34, cobN, CobN protein, len: 1217 aa. Highly similar to many e.g. Mycobacterium tuberculosis TR: O53498 (EMBL: AL021922) CobN (1194 aa), fasta scores opt: 2277 z-score: 2513.8 E(): 0 62.2% identity in 1224 aa overlap and Pseudomonas denitrificans SW:COBN_PSEDE (EMBL: M62866) CobN protein (1275 aa), fasta scores opt: 2437 z-score: 2690.5 E(): 0 41.6% identity in 1258 aa overlap. Also similar to metal chelatases e.g. Heliobacillus mobilis TR:Q9ZGE5 (EMBL: AF080002) Mg chelatase subunit H (1292 aa), fasta scores opt: 1647 z-score: 1815.7 E(): 0 31.4% i [...]
      
 0.806
SCO1851
SCI8.36, cobO, cob(I)alamin adenosyltransferase (EC 2.5.1.17), len: 199 aa. Highly similar to many including: Pseudomonas denitrificans SW:COBO_PSEDE (EMBL: M62866) cob(I)alamin adenosyltransferase (EC 2.5.1.17) (corrinoid adenosyltransferase) (213 aa), fasta scores opt: 418 z-score: 517.2 E(): 1.9e-21 37.0% identity in 200 aa overlap and Mycobacterium tuberculosis TR:O05810 (EMBL: Z95207) cob(I)alamin adenosyltransferase CobA (207 aa), fasta scores opt: 918 z-score: 1124.4 E(): 0 64.7% identity in 207 aa overlap.
     
 0.739
SCO5803
SOS regulatory protein; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
 
   
 0.707
SCO2688
Riboflavin-specific deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
  
  
 0.677
SCO4106
SCD17.10, possible bifunctional enzyme deaminase/reductase, len: 376 aa. Similar to both domains of the Escherichia coli bifunctional SW:RIBD_ECOLI (EMBL; X64395) riboflavin biosynthesis protein RibD (367 aa). However the N-terminal domain of SCD17.10 is similar to the E. coli C-terminal reductase domain, fasta scores opt: 209 z-score: 241.1 E(): 4.5e-06 27.0% identity in 222 aa overlap and the C-terminal domain of SCD17.10 is similar to the E. coli N-terminal deaminase domain (blast scores Expect = 3.2e-07, P = 3.2e-07, Identities = 51/192 (26%), Positives = 77/192 (40%)). Also simila [...]
  
  
 0.677
SCO5224
SC7E4.21c, probable araC-family transcriptional regulator, len: 322 aa; similar to TR:Q9S166 (EMBL:AB023785) Streptomyces griseus transcriptional activator for strR, AdpA, 405 aa; fasta scores: opt: 1005 z-score: 1177.5 E(): 0; 49.2% identity in 325 aa overlapand to TR:CAB87229 (EMBL:AL163641) Streptomyces coelicolor araC-family transcriptional regulator AdpA, 398 aa; fasta scores: opt: 990 z-score: 1160.1 E(): 0; 48.9% identity in 313 aa overlap. Contains Pfam match to entry PF00165 HTH_AraC, Bacterial regulatory helix-turn-helix proteins, araC family and match to Prosite entry PS0004 [...]
      
 0.650
SCO3879
Chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity).
  
   
 0.617
SCO1441
3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
     
 0.597
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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