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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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co-expression
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SCO5863Two-component sensor (kinase); Member of the two-component regulatory system CutS/CutR, involved in the regulation of copper metabolism. (414 aa)    
Predicted Functional Partners:
SCO5862
Two-component regulator CutR; Member of the two-component regulatory system CutS/CutR, involved in the regulation of copper metabolism. CutR suppresses a defective melC1 gene, encoding a putative copper-transfer gene, probably by altering copper metabolism (By similarity).
 
 
 0.992
SCO4907
Transcriptional regulatory protein; Forms part of a two-component regulatory system AfsQ1/AfsQ2 involved in secondary metabolism.
 
 
 0.867
SCO3590
SC66T3.01c, probable two-component system response regulator, partial CDS, len: >62 aa; similar to many e.g. SW:CUTR_STRCO (EMBL:X58793), CutR, S.coelicolor two component response regulator involved in regulation of copper metabolism (217 aa), fasta scores; opt: 231 z-score: 316.5 E(): 2.7e-10, 56.5% identity in 62 aa overlap. The CDS continues as SCH66.11c in cosmid H66 (EMBL:AL049731); SCH66.11c, probable two component response regulator, len: 213 aa; similar to many e.g. SW:CUTR_STRCO two component response regulator involved in regulation of copper uptake in Streptomyces coelicolor [...]
 
   0.824
SCO5403
SC8F4.07, probable two-component system response regulator, len: 222 aa; similar to many e.g. SW:Q02540 (COPR_PSESM) CopR transcriptional activator protein from Pseudomonas syringae (pv. tomato) (227 aa) fasta scores; opt: 621, z-score: 735.4, E(): 0, 45.7% identity in 223 aa overlap. Contains a Pfam match to entry PF00072 response_reg, Response regulator receiver domain and Pfam match to entry PF00486 trans_reg_C, Transcriptional regulatory protein, C terminal.
 
   0.823
SCO7533
SC8G12.09, two-component system response regulator protein, len: 233 aa. Highly similar to many putative response regulators including: Amycolatopsis mediterranei TR:CAB82846(EMBL:AJ277082) putative response regulator (229 aa), fasta scores opt: 937 z-score: 1114.4 E(): 0 61.9% identity in 231 aa overlap and Streptomyces coelicolor TR:Q9ZEP4(EMBL:AJ131213) response regulator, SCE94.09 (234 aa), fasta scores opt: 665 z-score: 793.6 E():0 45.5% identity in 231 aa overlap. Contains a Pfam match to entry PF00072 response_reg, Response regulator receiver domain and a Pfam match to entry PF0 [...]
 
 
 0.820
SCO7230
SC2H12.29, possible two-component system response regulator, len: 229 aa. Highly similar to many other putative two-component system regulators e.g. Mycobacterium bovis SW:RGX3_MYCBO (EMBL:Y13627) sensory transduction protein, RegX3 (227 aa), fasta scores opt: 609 z-score: 727.0 E(): 0 44.7% identity in 226 aa overlap and Streptomyces coelicolor TR:CAB90891 (EMBL:AL355753) two-component system response regulator protein, SC8G12.09 (233 aa), fasta scores opt: 953 z-score: 1131.9 E(): 0 63.4% identity in 235 aa overlap. Contains a Pfam match to entry PF00072 response_reg, Response regula [...]
 
 
 0.817
SCO5778
SC4H8.17, two-component system transcriptional regulator, len: 228 aa; similar to many eg. VANR_ENTFA Q47744 regulatory protein VanR from enterococcuus faecalis (220 aa), fasta scores; opt: 469 z-score: 742.2 E(): 0, 37.1% identity in 224 aa overlap.
 
   0.816
SCO0552
SCF11.32c, possible response regulator, len: 238 aa; similar to TR:CAB54568 (EMBL:AJ006392) Streptococcus pneumoniae response regulator Rro2, 234 aa; fasta scores: opt: 583 z-score: 693.9 E(): 2.8e-31; 43.2% identity in 227 aa overlap. Contains Pfam matches to entries PF00486 trans_reg_C, transcriptional regulatory protein and PF00072 response_reg, response regulator receiver domain.
 
   0.815
SCO5748
SC7C7.03, probable sensory histidine kinase, len: 1829 aa; N-terminus has 11 92aa repeats. Highly similar to putative osmosensing histidine kinases from yeasts (with only five repeats) e.g. Neurospora crassa TR:Q01318 (EMBL:U53189) osmotic-1 locus putative histidine kinase (1298 aa), fasta scores; opt: 2011 z-score: 1764.6 E(): 0, 38.3% identity in 1281 aa overlap. Also similar to BARA_ECOLI sensor protein BarA (918 aa) (with only one copy of the repeat), fasta scores; opt: 378 z-score: 755.8, E(): 0, 28.9% identity in 619 aa overlap. Extreme N-terminus has similarity to the phosphoryl [...]
   
 
 0.812
SCO4156
SCD84.23c, probable two-component systen response regulator, len: 248 aa; similar to SW:COPR_PSESM (EMBL:L05176) Pseudomonas syringae transcriptional activator protein CopR, 227 aa; fasta scores: opt: 610 z-score: 735.3 E(): 0; 42.7% identity in 227 aa overlap and to TR:O53894 (EMBL:AL021999) Mycobacterium tuberculosis putative two-component response regulator MTV044.09, 230 aa; fasta scores: opt: 933 z-score: 1119.0 E(): 0; 62.9% identity in 229 aa overlap. Contains Pfam matches to entries PF00072 response_reg, Response regulator receiver domain and PF00486 trans_reg_C, Transcriptiona [...]
 
   0.805
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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