STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO5905SC10A5.10c, probable export protein, len: 847 aa; similar to eg. S. coelicolor actinorhodin antibiotic export protein TR:Q53902 (EMBL:M64683) ORF2 (ACTII) (711 aa), fasta scores; opt: 705 z-score: 1126.2 E(): 0, 35.4% identity in 746 aa overlap. (847 aa)    
Predicted Functional Partners:
SCO0905
Putative membrane protein; SCM1.38, possible membrane protein, len: 101 aa. Highly similar to the very C-terminus of Streptomyces coelicolor SW:MMLA_STRCO(EMBL:M64683) putative membrane protein ACTII-3 (711 aa), fasta scores opt: 232 z-score: 254.6 E(): 7.8e-07 48.3% identity in 87 aa overlap. Contains a possible N-terminal signal sequence and a possible membrane spanning hydrophobic domain.
  
     0.715
SCO2426
SCC42.07, possible regulatory protein, len: 403 aa; similar to TR:CAB88166 (EMBL:AL352956) Streptomyces coelicolor putative regulatory protein SC1H10.22c, 555 aa; fasta scores: opt: 157 z-score: 183.8 E(): 0.0091; 26.8% identity in 447 aa overlap. Contains a possible helix-turn-helix motif at residues 347..863 (+3.80 SD) and two TTA leucine codons (codon 170 and codon 174), possible targets for bldA regulation.
  
   
 0.701
SCO5904
Conserved hypothetical protein; SC10A5.09c, unknown, len: 126 aa; similar to Mycobac terium tuberculosis hypothetical protein TR:O06156 (EMBL:Z9 5555) MTCY06F7.02C (105 aa), fasta scores; opt: 125 z-score : 213.5 E(): 0.00011, 37.7% identity in 69 aa overlap.
  
    0.671
SCO4451
SCD6.29, probable export protein, len: 541 aa; similar to TR:CAB61602 (EMBL:AL133210) Streptomyces coelicolor putative export protein, SCG11.21c, 533 aa; fasta scores: opt: 832 z-score: 842.6 E(): 0; 33.7% identity in 531 aa overlap and to SW:TCMA_STRGA (EMBL:M80674) Streptomyces glaucescens tetracenomycin C resistance and export protein TcmA, 538 aa; fasta scores: opt: 701 z-score: 710.8 E(): 3.9e-32; 29.3% identity in 543 aa overlap. Contains possible hydrophobic membrane spanning regions.
    
 
 0.658
SCO0254
SCJ9A.33c, hypothetical protein, len: 246 aa; weakly similar to TR:Q18926 (EMBL:U23517) hypothetical protein from the eukaryote Caenorhabditis elegans (243 aa) fasta scores; opt: 354, z-score: 396.7, E(): 9.9e-15, (28.3% identity in 240 aa overlap). Also weakly similar to TR:O87611 (EMBL:AF087482) dienelactone hydrolase from Pseudomonas aeruginosa (236 aa) fasta scores; opt: 212, z-score: 241.9, E(): 4.1e-06, (27.4% identity in 230 aa overlap). Similar also to TR:Q9I4H1 (EMBL:AE004547) Pseudomonas aeruginosa hypothetical protein PA1166, 262 aa; fasta scores: opt: 474 Z-score: 515.3 E() [...]
      
 0.648
SCO0908
Conserved hypothetical protein; SCM1.41, unknown, len: 154 aa. Similar to the C-terminus of a protein of unknown function in Mycobacterium tuberculosis TR:P71738(EMBL:Z81368) (189 aa), fasta scores opt: 451 z-score: 544.4 E(): 5.6e-23 48.7% identity in 154 aa overlap.
      
 0.648
SCO1394
SC1A8A.14, possible glycosyl hydrolase, len: 795 aa; similar to many e.g. SW:O59645 (AGLU_SULSO) alpha-glucosidase from Sulfolobus solfataricus (693 aa) fasta scores; opt: 535, z-score: 568.6, E(): 3e-24, 32.4% identity in 463 aa overlap. Contains Pfam match to entry PF01055 Glyco_hydro_31, Glycosyl hydrolases family 31.
      
 0.648
SCO1854
Putative permease; SCI39.01c, possible integral membrane protein (fragment), len: >174 aa. Contains possible hydrophobic membrane spanning regions; SCI8.39, possible permease, partial CDS, len: > 104 aa. Weakly similar to Escherichia coli SW:BTUC_ECOLI (EMBL: M14031) vitamin B12 transport system permease protein (326 aa), fasta scores opt: 101 z-score: 140.5 E():1.9 32.5% identity in 77 aa overlap. Contains possible membrane spanning hydrophobic domains.
      
 0.648
SCO1993
Hypothetical protein; SC7H2.07c, unknown, len: 228aa.
      
 0.648
SCO2262
SCC75A.08c, possible oxidoreductase, len: 239 aa. Similar to several including: Methanobacterium thermoautotrophicum TR:O59661(EMBL:Y17210) F420-dependent NADP reductase (224 aa), fasta scores opt: 257 z-score: 283.4 E(): 2.1e-08 38.3% identity in 222 aa overlap and Archaeoglobus fulgidus TR:O29059(EMBL:AE001021) conserved hypothetical protein (213 aa), fasta scores opt: 397 z-score: 431.0 E(): 1.2e-16 37.3% identity in 204 aa overlap.
      
 0.648
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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