STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO5958Cobalt transport system ATP binding protein; Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity). (284 aa)    
Predicted Functional Partners:
SCO5959
SC7H1.29c, cbiQ, probable cobalt transport integral membrane protein, len: 249 aa; similar to eg. CBIQ_SALTY Q05598 cobalt transport protein cbiq (225 aa), fasta scores; opt: 182 z-score: 241.4 E(): 3e-06, 28.1% identity in 228 aa overlap.
 
 0.999
SCO5961
Puative cobalt transport protein; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.
 
 0.997
SCO3160
SCE87.11, possible integral membrane transport protein, len: 253 aa. Similar to many proteins thought to be involved in the transport of cobalt e.g. Streptomyces coelicolor TR:O54188(EMBL:AL021411) cobalt transport integral membrane protein SC7H1.29c (CbiQ) (249 aa), fasta scores opt: 196 z-score: 249.6 E(): 1.6e-06 25.5% identity in 251 aa overlap and Methanobacterium thermoautotrophicum TR:O27740(EMBL:AE000928) cobalt transport membrane protein (261 aa), fasta scores opt: 332 z-score: 417.0 E(): 7.5e-16 30.2% identity in 212 aa overlap. Contains multiple possible membrane spanning hy [...]
 0.996
SCO5960
Puative cobalt transport protein; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import; Belongs to the CbiN family.
 
 
 0.996
SCO3159
SCE87.10, possible membrane protein, len: 353 aa. Weakly similar to Salmonella typhimurium SW:CBIM_SALTY (EMBL:L12006) cobalamin biosynthesis protein CbiM (245 aa), fasta scores opt: 224 z-score: 251.7 E(): 1.2e-06 32.8% identity in 180 aa overlap. Also similar to Methanobacterium thermoautotrophicum TR: O27742 (EMBL:AE000928) cobalamin biosynthesis protein M (217 aa), fasta scores opt: 495 z-score: 544.6 E(): 5.9e-23 41.4% identity in 220 aa overlap. Contains multiple possible membrane spanning hydrophobic domains and a possible N-terminal signal sequence.
 
 0.988
SCO2323
SCC53.14, possible integral membrane protein, len: 379aa; contains possible membrane-spanning hydrophobic regions.
 
 
 0.944
SCO2630
SC8E4.05c, possible biotin synthase, len: 246 aa; similar to TR:AAF12013 (EMBL:AE002076) Deinococcus radiodurans biotin synthase putative DR2470, 229 aa; fasta scores: opt: 293 z-score: 315.9 E(): 3.5e-10; 33.0% identity in 209 aa overlap and to SW:BIOY_BACSH (EMBL:M29292) Bacillus sphaericus BioY protein, 196 aa; fasta scores: opt: 275 z-score: 299.1 E(): 3e-09; 35.5% identity in 155 aa overlap. Contains possible hydrophobic membrane spanning regions.
   
 
 0.912
SCO3161
Putative ABC transport protein, ATP-binding subunit; Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity).
  
  
 
0.910
SCO1857
SCI39.04, probable bifunctional protein (CbiGH), len: 583 aa; N-terminal region similar to SW:CBIG_SALTY (EMBL:L12006) Salmonella typhimurium involved in cobalamin synthesis CbiG protein, 351 aa; fasta scores: opt: 312 Z-score: 304.6 bits: 65.6 E(): 2.2e-09; 32.986% identity in 288 aa overlap and C-terminal region similar to SW:CBIH_SALTY (EMBL:L12006) Salmonella typhimurium precorrin-3B C17-methyltransferase (EC 2.1.1.131) CbiH, 241 aa; fasta scores: opt: 684 Z-score: 658.7 bits: 130.6 E(): 4.3e-29; 46.862% identity in 239 aa overlap. Contains Pfam match to entry PF01890 CbiG, CbiG an [...]
 
  
 0.781
SCO5524
SC1C2.05c, possible transmembrane transport protein, len: 476 aa; similar to e.g. B. subtilis TR:P94369 (EMBL:D83026) yxlA (homologous to purine-cytosine permease) (457 aa), fasta scores; opt: 235 z-score: 377.4 E(): 9e-14, 24.0% identity in 475 aa overlap; Belongs to the purine-cytosine permease (2.A.39) family.
      
 0.770
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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