STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO6122SC9B2.09, possible membrane protein, len: 192aa; similar to TR:O32455 (EMBL:D87924) the 5th gene in the putative polyketide synthase genes for pradimicin biosynthesis from Actinomadura hibisca (153 aa) fasta scores; opt: 129, z-score: 175.5, E(): 0.017, (31.1% identity in 122 aa overlap) and to TR:Q9RDS5 (EMBL:AL136500) Streptomyces coelicolor putative membrane protein SC1G2.04c, 148 aa; fasta scores: opt: 727 Z-score: 852.7 E(): 7.3e-40; 75.510% identity in 147 aa overlap. Contains possible hydrophobic membrane spanning regions. (148 aa)    
Predicted Functional Partners:
SCO6121
SC9B2.08c, possible transcriptional regulator, len: 192 aa; similar to many e.g. TR:O34892 (EMBL:AF027868) proposed transcriptional regulator from Bacillus subtilis (191 aa) fasta scores; opt: 168, z-score: 207.7, E(): 0.00028, (30.2% identity in 96 aa overlap) and SW:TER3_ECOLI tetracycline repressor protein class C from Escherichia coli (219 aa) fasta scores; opt: 149, z-score: 184.7, E(): 0.0053, (45.5% identity in 55 aa overlap). Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family. Also contains a probable helix-turn-helix (+4.23 SD) at residues 35..56.
 
     0.888
SCO2243
SC1G2.05, possible TetR-family transcriptional regulator, len: 192 aa. Similar to Bacillus subtilis TR:O34892 (EMBL:AF027868) putative transcription regulator YobS (191 aa), fasta scores opt: 179 z-score: 219.4 E(): 7.7e-05 27.9% identity in 165 aa overlap. Also highly similar to another putative transcriptional regulator from Streptomyces coelicolor TR:Q9Z551 (EMBL:AL035212) SC9B2.08C (192 aa), fasta scores opt: 1071 z-score: 1249.2 E(): 0 87.0% identity in 192 aa overlap. Contains a Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family with a possible helix-tur [...]
 
     0.766
SCO1407
Hypothetical protein; SC6D7.32, unknown, len: > 1425 aa. Weakly similar to several including: Streptomyces coelicolor TR:Q9Z5A4(EMBL:AL035478) putative secreted protein SC2G5.19 (1156 aa), fasta scores opt: 327 z-score: 314.0 E(): 4.1e-10 28.0% identity in 938 aa overlap and Rhodobacter capsulatus TR:O68032(EMBL:AF010496) potential exonuclease (1238 aa), fasta scores opt: 439 z-score: 421.6 E(): 4.1e-16 28.8% identity in 1154 aa overlap. The predicted protein product of this CDS is alanine rich and contains multiple probable coiled-coils between residues: 369 to 401 (33 residues), 406 [...]
  
     0.528
SCO7826
Hypothetical protein SC8E7.23c; SC8E7.23c, unknown, len: 326 aa.
  
     0.466
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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