STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO6234SC2H4.16, manA, probable secreted beta-mannosidase, len: 384 aa; 94.5% identical to MANA_STRLI mannan endo-1,4-beta-mannosidase precursor (363 aa). Contains PS00659 Glycosyl hydrolases family 5 signature and Pfam match to entry PF00150 cellulase, Cellulase (glycosyl hydrolase family 5), score 104.70, E-value 1.8e-27. (384 aa)    
Predicted Functional Partners:
SCO0554
SCF73.01c, manA, probable secreted beta-mannosidase, len: 327 aa; similar to many e.g. MANA_STRLI P51529 mannan endo-1,4-beta-mannosidase precursor (EC 3.2.1.78) (363 aa), fasta scores; opt: 1189 z-score: 1332.7 E(): 0, 61.1% identity in 288 aa overlap. Contains N-terminal signal sequence, and Pfam match to entry PF00150 cellulase, Cellulase (glycosyl hydrolase family 5). Also similar to SC2H4.16 (62.2% identity in 288 aa overlap); SCF11.34c, possible sugar hydrolase, partial CDS, len: >278 aa; C-teminus similar to SW:GUN4_THEFU (EMBL:L20093) Thermomonospora fusca endoglucanase E-4 pre [...]
  
  
 
0.903
SCO0382
SCF62.08, probable UDP-glucose/GDP-mannose family dehydrogenase (putative secreted protein), len: 441 aa. Highly similar to many e.g. Pseudomonas syringae (pv. phaseolicola) SW: ALGD_PSESH (EMBL; AF001555) GDP-mannose 6-dehydrogenase (EC 1.1.1.132) (438 aa), fasta scores opt: 1453 z-score: 1666.9 E(): 0 49.2% identity in 445 aa overlap. Contains a Pfam match to entry PF00984 UDPG_MGDP_dh, UDP-glucose/GDP-mannose dehydrogenase family.
    
  0.805
SCO1957
SCC54.17, probable fructokinase, len: 302 aa; similar to many e.g. SW:SCRK_RHILT Frk, fructokinase from Rhizobium leguminosarum biovar trifolii (326 aa) fasta scores; opt: 617, z-score: 682.4, E(): 1.1e-30, (41.0% identity in 288 aa overlap). Contains PS00584 pfkB family of carbohydrate kinases signature 2 and Pfam match to entry PF00294 pfkB, pfkB family carbohydrate kinase, score 132.90, E-value 9.6e-41.
     
  0.800
SCO0643
SCF91.03c, possible secreted cellulose-binding protein, len: 228 aa. Similar to several including: Streptomyces coelicolor TR:CAB50949 (EMBL:AL096849) putative secreted cellulose-binding protein SCI11.23 (356 aa), fasta scores opt: 349 z-score: 417.9 E(): 6.7e-16 32.2% identity in 227 aa overlap. Also weakly similar to chitin-binding proteins e.g. Streptomyces olivaceoviridis TR:Q54501 (EMBL:X78535) chitin binding protein precursor (201 aa), fasta scores opt: 203 z-score: 249.8 E(): 1.5e-06 29.3% identity in 222 aa overlap. Contains a possible N-terminal signal sequence.
 
  
 0.785
SCO1188
SCG11A.19, celS2, secreted cellulose binding protein len: 364 aa; highly similar to TR:AAD27623 (EMBL:AF126376) Streptomyces viridosporus cellulose binding protein CelS2, 358 aa; fasta scores: opt: 2109 z-score: 2160.9 E(): 0; 81.9% identity in 364 aa overlap and to SW:GUNA_MICBI Microbispora bispora endoglucanase A precursor (EC 3.2.1.4) (endo-1,4-beta-glucanase) (CELLULASE) CelA, 456 aa; fasta scores: opt: 350 z-score: 363.9 E(): 6.8e-13; 30.6% identity in 278 aa overlap. Contains match to Pfam entry PF00553 CBD_2, Cellulose binding domain. Contains also possible signal peptide sequence.
 
  
 0.772
SCO6548
SC5C7.33, probable secreted cellulase, len: 579 aa; similar to many, e.g. TR:Q60029 (EMBL:U18978) beta-1,4-exocellulase precursor (596 aa), fasta scores; opt: 2131 z-score: 2323.9 E(): 0, 62.1% identity in 585 aa overlap. Contains possible N-terminal signal sequence, PS00655 Glycosyl hydrolases family 6 signature 1 and Pfam match to entry PF00553 CBD_1, Cellulose binding domain, score 161.20, E-value 9.8e-46 near C-terminus.
  
     0.758
SCO0765
SCF81.24c, cel1, secreted endoglucanase, len: 747 aa; highly similar to SW:GUN1_STRRE (EMBL:X65616) Streptomyces reticulii cellulase 1 precursor (EC 3.2.1.4) (endoglucanase) (endo-1,4-beta-glucanase) (avicelase) Cel1, 746 aa; fasta scores: opt: 4213 z-score: 4621.9 E(): 0; 80.3% identity in 747 aa overlap. Contains two matches to Pfam entries PF00759 Glyco_hydro_9, Glycosyl hydrolase family 9 and to Prosite entry PS00698 Glycosyl hydrolases family 9 active sites signature 2. Also contains N-terminal region signal peptide sequence and a possible helix-turn-helix motif at residues 119..1 [...]
 
     0.752
SCO6546
SC5C7.31c, probable secreted cellulase, len: 973 aa; N-terminus is similar to the cellulose binding domain of e.g. GUN4_THEFU endoglucanase E-4 precursor (880 aa), fasta scores; opt: 341 z-score: 352.0 E(): 2.3e-12, 43.7% identity in 103 aa overlap. C-terminus is similar to many cellulases e.g. GUXB_CELFI exoglucanase B precursor (1090 aa), fasta scores; opt: 2997 z-score: 2688.8 E(): 0, 61.4% identity in 699 aa overlap. Contains probable N-terminal signal sequence and Pfam match to entry PF00553 CBD_1, Cellulose binding domain, score 122.30, E-value 2.4e-34 near N-terminus.
 
     0.750
SCO6545
SC5C7.30c, probable secreted cellulase, len: 890 aa; similar to TR:D1029971 (EMBL:AB015511) Aspergillus aculeatus avicelase III (856 aa), fasta scores; opt: 2099 z-score: 1414.5 E(): 0, 44.5% identity in 845 aa overlap, and to many others e.g. GUNA_MICBI endoglucanase A precursor (EC 3.2.1.4) (456 aa), fasta scores; opt: 416 z-score: 340.7 E(): 9.9e-12, 28.5% identity in 449 aa overlap (strongest in the cellulose-binding domain). Contains probable N-terminal signal sequence and Pfam match to entry PF00553 CBD_1, Cellulose binding domain, score 171.70, E-value 8.5e-49 at C-terminus.
  
     0.744
SCO1187
SCG11A.18, celB, secreted cellulase B precursor, len: 381 aa; identical to TR:Q54331 (EMBL:U04629) Streptomyces lividans cellulase precursor, celB, 381 aa and similar to SW:GUX_CELFI (EMBL:M15824) Cellulomonas fimi exoglucanase/xylanase precursor [includes: exoglucanase (EC 3.2.1.91) (exocellobiohydrolase) (1,4-beta-cellobiohydrolase) (beta-1,4- glycanase Cex); endo-1,4-beta-xylanase B (EC 3.2.1.8) (xylanase B) Cex or XynB, 484 aa; fasta scores: opt: 422 z-score: 450.5 E(): 1e-17; 48.8% identity in 123 aa overlap. Contains two matches to Pfam entries PF01670 Glyco_hydro_12, Glycosyl hy [...]
  
     0.727
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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