STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO6266SCAH10.31, scbA, len: 314 aa; identical to previously sequenced TR:O86851 (EMBL:AJ007731) Streptomyces coelicolor ScbA protein, 314 aa and to SW:AFSA_STRGR (EMBL:M24250) Streptomyces griseus possible A-factor biosynthesis enzyme AfsA, 301 aa; fasta scores: opt: 1345 z-score: 1570.4 E(): 0; 66.1% identity in 292 aa overlap. (314 aa)    
Predicted Functional Partners:
SCO6265
SCAH10.30c, scbR, gamma-butyrolactone binding protein, len: 215 aa; identical to previously sequenced TR:O86852 (EMBL:AJ007731) Streptomyces coelicolor gamma-butyrolactone binding protein, 215 aa and to TR:O24741 (EMBL:AB001683) Streptomyces sp. FarA, 221 aa; fasta scores: opt: 771 z-score: 937.4 E(): 0; 57.2% identity in 208 aa overlap. Contains match to Pfam entry PF00440 tetR, Bacterial regulatory proteins, tetR family and to Prosite entry PS01081 Bacterial regulatory proteins, tetR family signature. Contains also a possible helix-turn-helix motif at residues 30..51 (+3.66 SD).
 
   
 0.968
SCO6267
SCAH10.32, hypothetical protein orfA, len: 284 aa; identical to previously sequenced TR:O86850 (EMBL:AJ007731) Streptomyces coelicolor hypothetical 31.0 kD protein, 284 aa and to various hypothetical proteins, e.g. TR:O68920 (EMBL:AF058302) Streptomyces roseofulvus FrnS, 305 aa; fasta scores: opt: 591 z-score: 680.7 E(): 1.5e-30; 41.5% identity in 282 aa overlap.
     
 0.771
SCO6071
SC9B1.18, cprB, A-factor receptor homolog, len: 215 aa; previously sequenced therefore identical to TR:O66122 (EMBL:AB000385) CprB, A-factor receptor homolog from Streptomyces coelicolor. Also similar to many others from Actinomycetes e.g. TR:Q54189 (EMBL:D49782) A-factor receptor from Streptomyces griseus (276 aa) fasta scores; opt: 315, z-score: 392.1, E(): 1.6e-14, (36.5% identity in 219 aa overlap). Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family.
 
   
 0.732
SCO6312
SCIF3.14c, cprA, transcriptional regulator, len: 215 aa; identical to previously sequenced TR:O66121 (EMBL:AB000384) Streptomyces coelicolor CprS, 215 aa. Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family and possible helix-turn-helix motif at residues 30..51 (+3.61 SD).
 
   
 0.730
SCO6286
SC1G7.12c, possible regulatory protein, len: 24 aa; similar to TR:O24739 (EMBL:AB001609) Streptomyces virginiae butyrolactone autoregulator receptor protein BarB, 216 aa; fasta scores: opt: 565 Z-score: 645.4 bits: 126.6 E(): 2.3e-28; 48.980% identity in 196 aa overlap. Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins.
 
   
 0.677
SCO4825
SC2A6.10, possible integral membrane protein, len: 178 aa; similar to TR:O32878 (EMBL:Z98271) Mycobacterium leprae hypothetical 9.6 kD protein MLCB1779.16c, 91 aa; fasta scores: opt: 148 z-score: 174.2 E(): 0.032; 27.5% identity in 80 aa overlap. Contains possible hydrophobic membrane spanning regions.
  
     0.648
SCO5877
Transcriptional regulator RedD; The RedD protein is probably one of several delicately balanced regulatory factors that contribute to the control of the biosynthesis of the antibiotic undecylprodigiosin (Red) in S.coelicolor.
      
 0.646
SCO7252
SC5H1.40c, possible regulatory protein, len: 502 aa; similar to e.g. SW:SP15_STRGR (EMBL:M32687) Streptomyces griseus sporulation protein (529 aa), fasta scores; opt: 394 z-score: 452.2 E(): 7.2e-18, 27.9% identity in 530 aa. Similar to SC7A1.26 (EMBL:AL034447) S.coelicolor possible transcriptional regulator (500 aa) (43.0% identity in 491 aa overlap).
  
   
 0.644
SCO3115
Hypothetical protein SCE41.24c; SCE41.24c, unknown, len: 889 aa. High content in alanine, glycine and proline amino acid residues. Contains 20x degenerate repeat: (G/P/A/N)P(G/P/A).
  
     0.631
SCO2321
SCC53.12, possible secreted protein, len: 419aa; contains possible cleavable N-terminal signal sequence and Pfam match to entry PF00432 prenyltrans, Prenyltransferase and squalene oxidase repeat.
  
     0.589
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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