STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO6440Conserved hypothetical protein; Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P); Belongs to the MfnB family. (250 aa)    
Predicted Functional Partners:
SCO6443
Conserved hypothetical protein SC9B5.10; Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
 
     0.830
SCO6441
SC9B5.08, probable aldehyde dehydrogenase, len: 468aa; similar to many eg. TR:O86742 (EMBL:AL031035) from Streptomyces coelicolor (479 aa) fasta scores; opt: 917, z-score: 901.0, E(): 0, (36.9% identity in 450 aa overlap) and SW:FEAB_ECOLI phenylacetaldehyde dehydrogenase from Escherichia coli (499 aa) fasta scores; opt: 799, z-score: 841.1, E(): 0, (38.7% identity in 465 aa overlap). Contains Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase, PS00070 Aldehyde dehydrogenases cysteine active site and PS00687 Aldehyde dehydrogenases glutamic acid active site.
 
     0.820
SCO6442
SC9B5.09, probable alcohol dehydrogenase, len: 367aa; similar to many eg. SW:XYLB_PSEPU aryl-alcohol dehydrogenase from Pseudomonas putida (366 aa) fasta scores; opt: 928, z-score: 888.5, E(): 0, (42.6% identity in 366 aa overlap). Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases.
       0.812
SCO7536
SC8G12.12, possible integral membrane protein, len: 739 aa. Highly similar to many putative Streptomyces coelicolor membrane proteins including: TR:CAB59662(EMBL:AL132674) SCE87.17C (745 aa), fasta scores opt: 1860 z-score: 1926.0 E():0 66.5% identity in 740 aa overlap and SW:MMLC_STRCO(EMBL:AL031107) SC5A7.16C (705 aa), fasta scores opt: 596 z-score: 618.6 E(): 5.4e-27 38.7% identity in 744 aa overlap. Contains multiple possible membrane spanning hydrophobic domains and a possible N-terminal signal sequence.
      
 0.749
SCO3592
SC66T3.03, possible membrane protein, len: 330 aa; similar to TR:Q9L038 (EMBL:AL352956) Streptomyces coelicolor putative membrane protein SC1H10.06c, 301 aa; fasta scores: opt: 557 Z-score: 630.1 E(): 1.8e-27; 50.968% identity in 310 aa overlap. Contains hydrophobic, possible membrane-spanning regions at the N-terminus region.
      
 0.668
SCO2518
SCC121.21c, possible two-component sensor kinase, len: 447 aa; similar to various S. coelicolor two-component sensor kinases, e.g. TR:CAB51250 (EMBL:AL096872) Streptomyces coelicolor putative two-component sensor kinase SC5F7.35c, 416 aa; fasta scores: opt: 752 z-score: 802.9 E(): 0; 40.7% identity in 410 aa overlap.
      
 0.646
SCO5897
Putative oxidase; SC10A5.02, redG, probable oxidase, len: 395 aa; similar in N- terminus to many diverse oxidases e.g. TR:P95483 (EMBL:U7449 3) aminopyrrolnitrin oxidase PrnD from Pseudomonas fluorescens (363 aa), fasta scores; opt: 349 z-score: 372.1 E(): 1. 6e-13, 33.3% identity in 165 aa overlap.
      
 0.642
SCO6439
SC9B5.06c, possible DNA-binding protein, len: 162 aa; similar in parts to many eukaryotic Y-box binding proteins (cold shock proteins) eg. SW:YB1_CHICK Y-box binding protein from Gallus gallus (chicken) (321 aa) fasta scores; opt: 165, z-score: 278.2, E(): 3.3e-08, (34.9% identity in 106 aa overlap) and TR:O53883 (EMBL:AL022004) proposed cold shock protein B from Mycobacterium tuberculosis (135 aa) fasta scores; opt: 174, z-score: 248.0, E(): 1.6e-06, (34.4% identity in 96 aa overlap). Contains Pfam match to entry PF00313 CSD, 'Cold-shock' DNA-binding domain.
       0.474
SCO2113
Putative bacterioferritin; Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.
      
 0.422
SCO2166
SC5F7.35c, probable two component sensor kinase, len: 416 aa; similar to many others from Streptomyces coelicolor egs. TR:CAB40930 (EMBL:AL049630) putative two component sensor kinase (401 aa) fasta scores; opt: 731, z-score: 799.1, E(): 0, (36.7% identity in 398 aa overlap) and TR:Q53893 (EMBL:U51332) two component sensor kinase for the regulation of antibiotic production (571 aa) fasta scores; opt: 429, z-score: 469.2, E(): 8.4e-19, (29.5% identity in 407 aa overlap). Contains possible membrane spanning hydrophobic regions.
      
 0.414
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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