STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO6457SC9B5.24, lacZ*, beta-galactosidase, len: 1307 aa; similar to many e.g. TR:O85167 (EMBL:AF047824) beta-galactosidase from Bacillus megaterium (1034 aa) fasta scores: opt: 1750, z-score: 2221.6, E(): 0, (37.4% identity in 1256 aa overlap). Note that this CDS is approx. 300 residues longer than the homologues due to an extra region around residues 600 to 900. Contains PS00719 Glycosyl hydrolases family 2 signature 1 and PS00608 Glycosyl hydrolases family 2 acid /base catalyst. Also contains Pfam match to entry PF00703 glycosyl_hydro7, Glycosyl hydrolases family 2. (1307 aa)    
Predicted Functional Partners:
SCO0284
SCF85.12, possible secreted alpha-galactosidase, len: 680 aa. Highly similar to many Eukaryotic alpha-galactosidases over the first 415 aa, e.g. Coffea arabica (Coffee) alpha-galactosidase precursor (EC 3.2.1.22) (melibiase) (378 aa),opt: 1323 z-score: 1416.9 E(): 0; 54.5% identity in 354 aa overlap, in addition to Saccharopolyspora erythraea (Streptomyces erythraeus)alpha galactosidase precursor MelA (428 aa),fasta scores opt: 623 z-score: 668.6 E(): 6.9e-30 50.6% identity in 427 aa overlap. Contains a PS00512 Alpha-galactosidase signature, a PS00599 Aminotransferases class-II pyridox [...]
 
 0.958
SCO6347
Beta-galactosidase; SC3A7.15, probable beta-galactosidase, len: 595; similar to many e.g. TR:O31341 (EMBL:D88750) beta-galactosidase (EC 3.2.1.23) (lactase) from Bacillus circulans (586 aa), fasta scores; opt: 1648 z-score: 1500.8 E(): 0, 43.0% identity in 584 aa overlap., Contains PS01182 Glycosyl hydrolases family 35 putative active site.
 
 
 0.941
SCO2393
Putative aldose 1-epimerase; Converts alpha-aldose to the beta-anomer.
 
 
 0.940
SCO2407
Putative aldose 1-epimerase; Converts alpha-aldose to the beta-anomer.
 
 
 0.939
SCO0766
SCF81.25c, possible secreted beta-galactosidase, len: 1028 aa; similar to SW:BGA2_ECOLI (EMBL:M64441) Escherichia coli evolved beta-galactosidase alpha-subunit (EC 3.2.1.23) (lactase) 1031 aa; fasta scores: opt: 482 z-score: 519.9 E(): 1.4e-21; 30.6% identity in 464 aa overlap. Contains N-terminal signal peptide sequence; Belongs to the glycosyl hydrolase 2 family.
  
  
 
0.930
SCO0274
SCF85.02, possible alpha-galactosidase, len: 499 aa. Similar to many alpha galactosidases e.g. Thermus aquaticus TR:AAD32628(EMBL; AF135399) alpha-galactosidase (476 aa), fasta scores opt: 1329 z-score: 1530.0 E(): 0 45.8% identity in 487 aa overlap.
 
 
 0.928
SCO5689
SC5H4.13, probable beta-galactosidase, len: 656 aa; similar to SW:BGAL_BACST (EMBL:M13466) Bacillus stearothermophilus beta-galactosidase I (EC 3.2.1.23) (lactase) BgaB, 672 aa; fasta scores: opt: 1761 z-score: 2065.7 E(): 0; 41.3% identity in 634 aa overlap and to TR:CAB76326 (EMBL:AL158061) Streptomyces coelicolor probable beta-galactosidase SC6D11.03c, 681 aa; fasta scores: opt: 1739 z-score: 1719.0 E(): 0; 46.0% identity in 670 aa overlap.
 
 
 0.926
SCO3479
SCE65.15c, possible beta-galatosidase, len: 995 aa; similar to SW:BGAL_ECOLI (EMBL:J01636) Escherichia coli beta-galactosidase (EC 3.2.1.23) (lactase) lacZ, 1023 aa; fasta scores: opt: 1594 z-score: 1693.3 E(): 0; 33.6% identity in 1039 aa overlap. Contains Pfam match to entry PF00703 Glyco_hydro_2, Glycosyl hydrolases family and match to Prosite entry PS00719 Glycosyl hydrolases family 2 signature 1.
  
  
 
0.924
SCO0541
SCF11.21, probable alpha-galactosidase, len: 441 aa; similar to SW:AGAL_BACSU (EMBL:AF008220) Bacillus subtilis alpha-galactosidase (EC 3.2.1.22) (Melibiase) MelA, 432 aa; fasta scores: opt: 1068 z-score: 1240.5 E(): 0; 39.3% identity in 427 aa overlap.
 
  
 0.923
SCO7407
SC6D11.03c, probable beta-galactosidase, len: 681 aa. Similar to many beta-galactosidases e.g. Bacillus stearothermophilus SW:BGAL_BACST(EMBL:M13466) beta-galactosidase I (EC 3.2.1.23), BgaB, (672 aa), fasta scores opt: 1816 z-score: 2079.7 E(): 0 43.2% identity in 666 aa overlap.
   
 0.916
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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