STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO6590SC8A6.11c, probable secreted esterase, len: 735 aa; similar to TR:Q54345 (EMBL:Z50108) esterase precursor from Streptomyces lividans (509 aa), fasta scores; opt: 553 z-sc ore: 526.3 E(): 4.5e-22, 38.2% identity in 403 aa overlap a nd to other membres of the trypsin family. Contains probabl e N-terminal signal sequence and Pfam match to entry PF0008 9 trypsin, Trypsin, score 31.60, E-value 4.4e-07. (735 aa)    
Predicted Functional Partners:
SCO6593
Hypothetical protein; SC8A6.14c, unknown, len: 1147 aa; contains two Ala-rich domains, PS00017 ATP/GTP-binding site motif A (P-loop) and probable coiled-coil regions from 238 to 292, 399 to 441, 445 to 488, 490 to 573, 786 to 820, and 829 to 871.
 
   
 0.957
SCO6591
SC8A6.12c, possible secreted protein, len: 168 aa; c ontains possible N-terminal signal sequence.
     
 0.933
SCO6198
SC2G5.19, possible secreted protein, len: 1156aa; alanine rich, similar to TR:O87848 (EMBL:AL031013) hypothetical protein from Streptomyces coelicolor (1147 aa) fasta scores; opt: 2516, z-score: 2119.1, E(): 0, (44.6% identity in 1122 aa overlap). Contains possible N-terminal signal sequence.
 
   
 0.898
SCO6592
SC8A6.13c, probable secreted protein, len: 129 aa; c ontains N-terminal signal sequence and appropriately positi oned PS00013 Prokaryotic membrane lipoprotein lipid attachm ent site.
     
 0.877
SCO6594
SC8A6.15c, probable secreted protein, len: 602 aa; c ontains probable N-terminal signal sequence.
     
 0.836
SCO0545
SCF11.25, possible secreted protein, len: 843 aa; similar to TR:O87849 (EMBL:AL031013) Streptomyces coelicolor putative secreted protein, 602 aa; fasta scores: opt: 2859 z-score: 3026.4 E(): 0; 72.1% identity in 555 aa overlap. Contains possible N-terminal signal sequence.
      
 0.775
SCP1.201
Hypothetical protein; SCP1.201, unknown, len: 1336aa; similar to TR:O87848 (EMBL:AL031013) hypothetical protein from Streptomyces coelicolor (1147 aa) fasta scores; opt: 1652, z-score: 1478.4, E(): 0, 38.7% identity in 926 aa overlap. Note possible alternative upstream translational start site which would give a possible N-terminal signal sequence. Contains several possible coiled-coil regions.
 
   
 0.773
SCO6197
SC2G5.18c, possible secreted protein, len: 180 aa; similar to TR:O87846 (EMBL:AL031013) putative secreted protein from Streptomyces coelicolor (168 aa) fasta scores; opt:476, z-score: 556.4, E(): 1e-23, (45.3% identity in 170 aa overlap). Contains possible N-terminal signal sequence.
     
 0.727
SCO7461
SCBAC14E8.01c, probable hydrolase, len: 228 aa; similar to SW:TRYD_DROME (EMBL:U04853) Drosophila melanogaster trypsin delta precursor (EC 3.4.21.4) Try-delta, 253aa; fasta scores: opt: 220 Z-score: 237.9 bits: 51.4 E(): 1.1e-05; 32.271% identity in 251 aa overlap. Contains Pfam match to entry PF00089 trypsin, Trypsin.
  
     0.665
SCO6736
SC5F2A.19c, possible metallopeptidase, len: 506aa; similar to many egs. TR:O69971 (EMBL:AL022268) proposed zinc metallopeptidase from Streptomyces coelicolor (512 aa) fasta scores; opt: 934, z-score: 1039.4, E(): 0, (36.3% identity in 509 aa overlap) and TR:G4063364 (EMBL:AF081952) from Thermoplasma acidophilum (780 aa) fasta scores; opt: 387, z-score: 428.8, E(): 1.4e-16, (28.2% identity in 447 aa overlap). Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.
  
 
 0.503
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.