STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO6599SC8A6.20c, probable transcriptional regulator, len: 217 aa; some similarity to members of the tetR family e.g. TER4_ECOLI tetracycline repressor protein class D (217 aa), fasta scores; opt: 158 z-score: 233.4 E(): 9.2e-06, 35.2% identity in 88 aa overlap. Contains probable helix-turn-helix motif at aa 29-50 (Score 1279, +3.54 SD) and Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family, score 31.90, E-value 4.2e-07. (217 aa)    
Predicted Functional Partners:
SCO1099
2SCG4.15c, possible integral membrane protein, len: 577 aa; similar to TR:O32225 (EMBL:Z99121) Bacillus subtilis YvaC protein, 631 aa; fasta scores: opt: 259 z-score: 265.7 E(): 2.6e-07; 26.5% identity in 578 aa overlap. Contains possible hydrophobic membrane spanning regions.
  
    0.558
SCO1191
SCG11A.22c, possible marR-family transcriptional regulator, len: 157 aa; low similarity to TR:CAB48917 (EMBL:AL096837) Streptomyces coelicolor putative marR-family transcriptional regulator SCF43A.30c, 169 aa; fasta scores: opt: 125 z-score: 167.7 E(): 0.058; 30.6% identity in 147 aa overlap.
  
     0.540
SCO0677
Secreted chitosanase; Aids in the defense against invading fungal pathogens by degrading their cell wall chitosan.
  
     0.513
SCO7624
SC2H2.22c, possible tetR-family regulatory protein, len: 231 aa; similar to many other putative tetR-family transcriptional regulators, e.g. TR:CAC08314 (EMBL:AL392149) Streptomyces coelicolor putative tetR-family transcriptional regulatory protein SCD19.13c, 268 aa; fasta scores: opt: 456 z-score: 539.8 E(): 1.6e-22; 38.4% identity in 232 aa overlap. Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family.
  
     0.500
SCO0444
SCF51A.22c, possible integral membrane protein, len: 133 aa. Contains possible membrane spanning hydrophobic domains.
  
     0.497
SCO6921
Putative membrane protein; SC1B2.27c, possible membrane protein, len: 576 aa. Contains a 4xPTTPQSGTDTTQDQG repeat sequence and multiple possible membrane spanning hydrophobic domains.
  
     0.483
SCO1272
2SCG18.19c, probable acyl carrier protein, len: 90 aa; similar to SW:ACPA_STRCO (EMBL:X63449) Streptomyces coelicolor actinorhodin polyketide synthase acyl carrier protein (ActI-ORF3), 86 aa; fasta scores: opt: 189 z-score: 253.9 E(): 1.2e-06; 40.2% identity in 82 aa overlap. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site and match to Prosite entry PS00012 Phosphopantetheine attachment site.
  
     0.472
SCO6600
SC8A6.21c, probable transcriptional regulator, len: 441 aa; some similarity to members of the ROK family e.g. XYLR_ANATH xylose repressor (399 aa), fasta scores; opt: 365 z-score: 361.7 E(): 6.6e-13, 27.2% identity in 397 aa over lap. Contains Pfam match to entry PF00480 ROK, ROK family, score 38.10, E-value 3e-10.
       0.465
SCO7080
SC3A4.06c, possible insertion element transposase, len: 278 aa. Weakly similar to several transposases e.g. Fremyella diplosiphon SW:TRA2_FREDI(EMBL:X60384) probable transposase for insertion sequence element IS702 (276 aa), fasta scores opt: 147 z-score: 180.3 E(): 0.014 23.3% identity in 240 aa overlap. Contains a putative helix-turn-helix motif situated between residues 50..71 (+3.28 SD). Contains a TTA/leucine codon, possible target for bldA regulation.
  
     0.464
SCO1449
SCL6.06c, hypothetical protein, len: 152 aa; similar to SW:YBGC_ECOLI (EMBL:M16489) Escherichia coli hypothetical 15.6 kD protein in CydB-TolQ intergenic region YbgC, 134 aa; fasta scores: opt: 140 z-score: 193.8 E(): 0.0023; 26.7% identity in 116 aa overlap.
  
    0.461
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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