STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO6666SC5A7.16c, probable integral membrane protein len: 705 aa; similar to many hypothetical membrane proteins e.g. M. tuberculosis TR:E1299723 (EMBL:AL021928) MMPL3 (944 aa), fasta scores; opt: 482 z-score: 907.8 E(): 0, 33.3% identity in 744 aa overlap. (705 aa)    
Predicted Functional Partners:
SCO1797
SCI5.05c, possible integral membrane protein, len: 143aa; similar to TR:P71767 (EMBL:Z79701) hypothetical protein from Mycobacterium tuberculosis (144 aa) fasta scores; opt: 344, z-score: 409.3, E(): 1.8e-15, (44.8% identity in 134 aa overlap). Contains possible membrane spanning hydrophobic regions.
      
 0.880
SCO1855
SCI39.02, probable precorrin-4 C11-methyltransferase, len: 281 aa; similar to TR:O87696 (EMBL:AJ000758) Bacillus megaterium precorrin-4 methylase CbiF, 258 aa; fasta scores: opt: 674 Z-score: 771.2 bits: 150.4 E(): 2.3e-35; 41.502% identity in 253 aa overlap and to SW:COBM_PSEDE (EMBL:M59301) Pseudomonas denitrificans precorrin-4 C11-methyltransferase (EC 2.1.1.133) CobM, 253 aa; fasta scores: opt: 652 Z-score: 746.5 bits: 145.8 E(): 5.5e-34; 43.145% identity in 248 aa overlap. Contains Pfam match to entry PF00590 TP_methylase, Tetrapyrrole (Corrin/Porphyrin) Methylases.
      
 0.716
SCO5084
SCBAC28G1.10, actII-3, putative membrane protein, len: 711 aa; identical to previously sequenced SW:MMLA_STRCO (EMBL:M64683) Streptomyces coelicolor putative membrane protein ActII-3, 711 aa. Contains possible hydrophobic membrane spanning regions.
  
   
0.521
SCO6668
SC5A7.18c, probable two-component sensor, len: 405 aa; similar in C-terminus to many e.g. NARQ_ECOLI nitrate.
   
   0.495
SCO6667
SC5A7.17c, probable two-component regulator, len: 222 aa; highly similar to many e.g. DEGU_BACSU transcriptional regulatory protein DegU (229 aa), fasta scores; opt: 561 z-score: 630.7 E(): 7e-28, 44.0% identity in 225 aa overlap. Contains PS00622 Bacterial regulatory proteins, luxR family signature, probable helix-turn-helix motif from aa 173 to 194 (Score 1001, +2.60 SD) and Pfam matches to entry PF00072 response_reg, Response regulator receiver domain, score 124.10, E-value 2.7e-33 and entry PF00196 GerE, Bacterial regulatory proteins, luxR family, score 86.30, E-value 6.1e-22.
       0.490
SCO2777
SCC105.08, accC, acetyl/propionyl CoA carboxylase alpha subunit, len: 646 aa; similar to SW:PCCA_HUMAN (EMBL:X14608) Homo sapiens propionyl-CoA carboxylase alpha chain precursor (EC 6.4.1.3) PccA, 703 aa; fasta scores: opt: 1539 z-score: 1630.1 E(): 0; 43.0% identity in 665 aa overlap and to SW:ACCC_ECOLI (EMBL:M79446) Escherichia coli biotin carboxylase (EC 6.3.4.14), alpha subunit of acetyl CoA carboxylase (EC 6.4.1.2) AccC or FabG, 449 aa; fasta scores: opt: 1439 z-score: 1527.1 E(): 0; 47.9% identity in 451 aa overlap and to N-terminal region of TR:CAB59603 (EMBL:AL132662) Streptom [...]
      
 0.483
SCO2776
SCC105.07, accD1, acetyl/propionyl CoA carboxylase, beta subunit, len: 538 aa; similar to TR:O06165 (EMBL:Z95556) Mycobacterium tuberculosis, hypothetical 56.7 kD protein MTCY07A7.08c, 529 aa; fasta scores: opt: 2749 z-score: 3110.3 E(): 0; 76.5% identity in 532 aa overlap and to TR:AAF35258 (EMBL:AF059510) Arabidopsis thaliana 3-methylcrotonyl-CoA carboxylase non-biotinylated subunit (EC 6.4.1.4) MccB, 587 aa; fasta scores: opt: 2185 z-score: 2471.8 E(): 0; 60.4% identity in 540 aa overlap. Contains Pfam match to entry PF01039 Carboxyl_trans, Carboxyl transferase domain.
   
  
 0.431
SCO6669
SC5A7.19c, probable transcriptional regulator, len: 264 aa; similar to members of the iclR family e.g. GYLR_STRCO glycerol operon regulatory protein (254 aa), fasta scores; opt: 277 z-score: 318.0 E(): 1.8e-10, 31.4% identity in 245 aa overlap. Contains probable helix-turn-helix motif from aa 28-49 (Score 1240, +3.41 SD).
       0.426
SCO6665
SC5A7.15c, probable secreted glucosidase, len: 466 aa; similar to e.g. TR:G2981143 (EMBL:AF052745) beta-1,3-glucanase II from Oerskovia xanthineolytica (435 aa), fasta scores; opt: 313 z-score: 413.3 E(): 8.7e-16, 37.0% identity in 435 aa overlapand XYND_BACPO endo-1,4-beta-xylanase D precursor (Bacillus polymyxa) (635 aa), fasta scores; opt: 339 z-score: 315.2 E(): 2.6e-10, 27.5% identity in 447 aa overlap.
       0.406
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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