STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
SCO6799Threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate.; Belongs to the zinc-containing alcohol dehydrogenase family. (342 aa)    
Predicted Functional Partners:
SCO6800
2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
 
 
 0.994
SCO4962
2SCK31.22, probable amino acid deaminase, len: 416 aa; similar to SW:THD2_ECOLI (EMBL:M21312) Escherichia coli threonine deaminase TdcB, 409 aa; fasta scores: opt: 899 z-score: 948.9 E(): 0; 46.0% identity in 309 aa overlap. Contains Pfam match to entry PF00291 PALP, Pyridoxal-phosphate dependent enzyme and match to Prosite entry PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site.
   
 0.907
SCO7292
SC5F8.02c, possible threonine dehydratase, len: 319 aa. Similar to many including: Escherichia coli SW:THD2_ECOLI(EMBL:M21312) threonine dehydratase catabolic (EC 4.2.1.16) TdcB (329 aa), fasta scores opt: 609 z-score: 676.6 E(): 3.2e-30 39.4% identity in 312 aa overlap. Contains a Prosite hit to Serine/threonine dehydratases pyridoxal-phosphate attachment site and a Pfam match to entry PF00291 S_T_dehydratase, Pyridoxal-phosphate dependent enzyme.
   
 0.907
SCO1087
2SCG4.03c, probable aldolase, len: 356 aa; similar to TR:O50584 (EMBL:AB001577) Pseudomonas sp. low specificity L-threonine aldolase, 346 aa; fasta scores: opt: 832 z-score: 977.3 E(): 0; 41.3% identity in 339 aa overlap and to SW:LTAA_AERJA (EMBL:D87890) Aeromonas jandaei L-allo-threonine aldolase (EC 4.1.2.-) LtaA, 338 aa; fasta scores: opt: 270 z-score: 321.1 E(): 2.1e-10; 26.9% identity in 324 aa overlap.
     
  0.900
SCO4293
SCD95A.26, probable threonine synthase, len: 428 aa; similar to TR:P73711 (EMBL:D90908) Synechocystis sp. threonine synthase ThrC, 433 aa; fasta scores: opt: 1467 z-score: 1612.7 E(): 0; 55.0% identity in 422 aa overlap. Contains Pfam match to entry PF00291 S_T_dehydratase, Pyridoxal-phosphate dependent enzyme.
   
 
  0.900
SCO5355
Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.
   
 
  0.900
SCO5890
SC3F7.10, redN, putative 8-amino-7-oxononanoate synthase, len: 640 aa; similar to many diverse transferases eg. BIOF_BACSH P22806 8-amino-7-oxononanoate synthase (389 aa), fasta scores; opt: 926 z-score: 888.4 E(): 0, 42.1% identity in 361 aa overlap. Also simlar to SC3F7.12 from aa 1700 to end (E(): 3.6e-15, 31.9% identity in 630 aa overlap). Contains Pfam match to entry aminotran_2 PF00222, Aminotransferases class-II, score 292.92 in C-terminus.
 
  
 0.745
SCO1243
2SCG1.18c, bioF, 8-amino-7-oxononanoate synthase, len: 375 aa; similar to SW:BIOF_BACSH (EMBL:M29291) Bacillus sphaericus 8-amino-7-oxononanoate synthase (EC 2.3.1.47) BioF, 389 aa; fasta scores: opt: 774 z-score: 785.6 E(): 0; 39.1% identity in 379 aa overlap. Contains Pfam match to entry PF00222 aminotran_2, Aminotransferases class-II and match to Prosite entry PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site.
 
  
 0.646
SCO6801
SC1A2.10, possible LysR-family transcriptional regulator, len: 300 aa. Similar to many other regulators e.g. Streptomyces coelicolor TR:CAB62680 (EMBL:AL133422) putative LysR-family transcriptional regulatory protein, SCM1.22C (301 aa), fasta scores opt: 673 z-score: 751.5 E():0 40.3% identity in 300 aa overlap. Contains 2x Prosite hits to PS00044 Bacterial regulatory proteins, lysR family signature and a Pfam match to entry PF00126 HTH_1, Bacterial regulatory helix-turn-helix protein, lysR family with the putative helix-turn-helix motif situated between residues 17..38 (+4.44 SD).
 
     0.645
SCO6804
Hypothetical protein SC1A2.13; SC1A2.13, unknown, len: 127 aa.
       0.553
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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