STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
SCO6998Putative cytochrome P450; Catalyzes oxidative C-C coupling reaction to polymerize flaviolin and form highly conjugated pigments which protect the soil bacterium from deleterious effects of UV irradiation (two isomers of biflaviolin and one triflaviolin). (407 aa)    
Predicted Functional Partners:
SCO5223
Putative cytochrome P450; Involved in the biosynthesis of the sesquiterpenoid antibiotic albaflavenone. Catalyzes the two-step allylic oxidation of epi-isozizaene to albaflavenone. First carries out a non-stereo- specific oxidation of epi-isozizaene to give a mixture of the albaflavenol epimers ((5R)-albaflavenol and (5S)-albaflavenol), each of which can serve as substrate for the second oxidation to yield albaflavenone. This is quite different from most other P450s which catalyze regio- and stereospecific oxidation. Displays also a farnesene synthase activity with farnesyl diphosphate [...]
  
   
 0.916
SCO3232
SCE63.01, partial CDS, cdaPS3, CDA peptide synthetase III, len: >332 aa; Constitutes the N-terminus of cdaPS3, CDA peptide synthetase III, part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This partial CDS encodes the N-terminus of a subunit of this enzyme suspected to be responsible for the addition of 2 amino acids to the peptide antibiotic. This ORF overlaps the upstream (cdaPSII) by one base indicating possible tra [...]
  
 
 0.908
SCO6432
SC1A6.21, probable peptide synthase, len: 1407 aa; similar to many e.g. TR:Q54959 (EMBL:X98690) Streptomyces pristinaespiralis Pristinamycin I synthase 2 (2591 aa), fasta scores; opt: 743 z-score: 754.8 E(): 0, 33.1% identity in1298 aa overlap. Contains PS00455 Putative AMP-binding domain signature, PS00012 Phosphopantetheine attachment site, PS00120 Lipases, serine active site and Pfam match to entry AMP-binding PF00501, AMP-binding enzymes, score 430.73.
  
 
 0.908
SCO7683
SC4C2.18, probable non-ribosomal peptide synthase, len: 1842 aa; similar to C-terminal domain of TR:AAG02364 (EMBL:AF210249) Streptomyces verticillus peptide synthetase NRPS2-1 BlmIV, 2626 aa; fasta scores: opt: 2514 z-score: 2613.8 E(): 0; 40.7% identity in 1287 aa overlap, to TR:Q9RFM7 (EMBL:AF184622) Pseudomonas aeruginosa pyochelin synthetase PchF, 1809 aa; fasta scores: opt: 2279 z-score: 2370.9 E(): 0; 39.7% identity in 1887 aa overlap, to TR:CAA18919 (EMBL:AL023496) Streptomyces coelicolor probable peptide synthase SC1A6.21, 1407 aa; fasta scores: opt: 1826 z-score: 1476.6 E(): [...]
  
 
 0.908
SCO6431
SC1A6.20, probable peptide synthase, len: 1171 aa; similar to many e.g. TR:Q44103 (EMBL:X97860) Amycolatopsis mediterranei aps gene for peptide synthetase (1324 aa), fasta scores; opt: 379 z-score: 1175.7 E(): 0, 32.3% identity in 993 aa overlap. Contains PS00455 Putative AMP-binding domain signature, PS00012 Phosphopantetheine attachment site and Pfam match to entry AMP-binding PF00501, AMP-binding enzymes, score 421.02.
  
 0.875
SCO0492
SCF34.11c, probable peptide synthetase, len: 3643 aa; similar to parts of many antibiotic peptide synthetases e.g. the C-terminal half of TR:Q9Z4X6 (EMBL:AL035640) Streptomyces coelicolor CDA peptide synthetase I (7463 aa), fasta scores; opt: 1948 z-score: 1929.3 E(): 0, 33.7% identity in 3723 aa overlap. Also similar to parts of putative peptide synthetases from the exochelin biosynthesis locus of Mycobacterium smegmatis TR:O87314 (EMBL:AF027770), FxbC, putative peptide synthetase (4976 aa) (42.3% identity in 3756 aa overlap). Contains 3 Pfam matches to entry PF00550 pp-binding, Phosp [...]
  
 0.869
SCO3230
SCE63.03c, cdaPSI, CDA peptide synthetase I, len: 7463 aa; part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This CDS encodes a subunit of this enzyme and is suspected to be responsible for the incorperation of the first 6 amino acids into the antibiotic structure. This ORF overlaps the downstream (cdaPSII) ORF by one base indicating possible translational coupling. Contains eight separate Pfam matches to entry PF00668 [...]
  
 0.869
SCO6827
SC4A9.04c, polyketide synthase, len: 2358 aa. Highly similar to many including: Stigmatella aurantiaca TR:AAF19813(EMBL:AF188287) polyketide synthase, MtAE, found within the Myxothiazol biosynthetic gene cluster (1947 aa), fasta scores opt: 2671 z-score: 2436.5 E():0 35.8% identity in 1770 aa overlap and Mycobacterium tuberculosis SW:PPSA_MYCTU(EMBL:Z74697) phenolpthiocerol synthesis polyketide synthase gene, PpsA (1876 aa), fasta scores opt: 2221 z-score: 2025.5 E(): 0 33.6% identity in 1761 aa overlap. Contains Prosite hits to PS00606 Beta-ketoacyl synthases active site and 2xPS00012 [...]
 
 0.864
SCO2003
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
    
 0.781
SCO0681
SCF15.02, possible ferredoxin/ferredoxin-NADP reductase (putative secreted protein), len: 454 aa. Similar to several eukaryotic and prokaryotic ferredoxin-NADP(+) reductases e.g. Rattus norvegicus (Rat) SW:ADRO_RAT (EMBL:D63761) NADPH:adrenodoxin oxidoreductase precursor (EC 1.18.1.2) (494 aa), fasta scores opt: 780 z-score: 902.2 E(): 0 36.3% identity in 463 aa overlap and Mycobacterium leprae TR:O32886 (EMBL:Z98271) possible ferredoxin (456 aa), fasta scores opt: 1030 z-score: 1191.5 E():0 39.2% identity in 454 aa overlap. Contains possible N-terminal region signal peptide sequence.
     
 0.683
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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