STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
SCO7638Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (434 aa)    
Predicted Functional Partners:
SCO1946
SCC54.06c, pgk, phosphoglycerate kinase, len: 403 aa; member of a family of proteins highly conserved across prokaryotes and eukaryotes, e.g. SW:PGK_BACSU Pgk, phosphoglycerate kinase from Bacillus subtilis (394 aa) fasta scores; opt: 1263, z-score: 1322.3, E(): 0, (51.2% identity in 404 aa overlap) and SW:PGKH_SPIOL phosphoglycerate kinase from Spinacia oleracea (Spinach) (433 aa) fasta scores; opt: 1200, z-score: 1256.1, E(): 0, (49.9% identity in 407 aa overlap). Contains PS00111 Phosphoglycerate kinase signature and Pfam match to entry PF00162 PGK, Phosphoglycerate kinases, score 6 [...]
 
 
 0.996
SCO2014
SC7H2.28c, pyk1, pyruvate kinase, len: 478 aa; strongly similar to many e.g. SW:KPYK_CORGL pyruvate kinase from Corynebacterium glutamicum (475 aa) fasta scores; opt: 1800, z-score: 2008.1, E(): 0, (59.6% identity in 473 aa overlap). Contains Pfam match to entry PF00224 PK, Pyruvate kinase and Prosite match to PS00110 Pyruvate kinase active site signature.
 
 0.990
SCO5423
SC8F4.27c, pyk2, pyruvate kinase, len: 476 aa; strongly similar to many e.g. SW:Q46078 (KPYK_CORGL) pyruvate kinase from Corynebacterium glutamicum (Brevibacterium flavum) (475 aa) fasta scores; opt: 1693, z-score: 1907.7, E(): 0, 55.3% identity in 474 aa overlap and TRNEW:CAB52070 (EMBL:AL109732) pyruvate kinase from Streptomyces coelicolor (478 aa) fasta scores; opt: 2185, z-score: 2461.2, E(): 0, 69.3% identity in 473 aa overlap. Contains Pfam match to entry PF00224 PK, Pyruvate kinase and Prosite match to PS00110 Pyruvate kinase active site signature.
 
 0.987
SCO4209
Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.
  
 0.985
SCO6818
Putative phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate.
  
 0.984
SCO3649
Putative fructose 1,6-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.
  
 0.978
SCO1942
SCC54.02c, pgi2, glucose-6-phosphate isomerase, len: 551 aa; Member of family of proteins conserved across prokaryotes and eukaryotes. Almost identical to another from Streptomyces coelicolor TR:O88015 (EMBL:AL031107) pgi, glucose-6-phosphate isomerase (550 aa) fasta scores; opt: 3305, z-score: 3849.4, E(): 0, (91.9% identity in 542 aa overlap). Also similar to SW:G6PI_ECOLI pgi, glucose-6-phosphate isomerase from Escherichia coli (549 aa) fasta scores; opt: 1950, z-score: 2271.0, E(): 0, (54.6% identity in 548 aa overlap) and SW:G6PI_MOUSE gpi, glucose-6-phosphate isomerase from Mus m [...]
  
 0.970
SCO6659
SC5A7.09c, pgi, glucose-6-phosphate isomerase, len: 550 aa; highly similar to many e.g. G6PI_ECOLI glucose-6-phosphate isomerase (EC 5.3.1.9) (549 aa), fasta sores; opt: 1878 z-score: 1900.7 E(): 0, 53.6% identity in 545 aa overlap. Contains PS00174 Phosphoglucose isomerase signature 2 and Pfam match to entry PF00342 PGI, Phosphoglucose isomerase, score 897.30, E-value 4.4e-266.
  
 0.970
SCO1945
Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P).
 
 
 0.965
SCO1947
Glyceraldehyde-3-phosphate dehydrogenase; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG; Belongs to the glyceraldehyde-3-phosphate dehydrogenase [...]
 
 
 0.964
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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