Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
SCO7822Probable prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.; Belongs to the Lgt family. (317 aa)    
Predicted Functional Partners:
SCO2036
Tryptophan synthase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
  
    0.911
SCO2074
Putative signal peptidase; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family.
 
   
 0.905
SCO2037
Tryptophan synthase beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
  
    0.891
SCO1014
Putative transferase; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily.
 
  
 0.862
SCO1336
Putative lipoprotein N-acyltransferase (integral membrane); Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily.
 
  
 0.836
SCO3884
SCH24.06, conserved hypothetical protein, len: 170 aa; previously sequenced as TR:O54595 (EMBL:Y16311) Streptomyces coelicolor jag-like protein (170 aa). Similar to SW:JAG_BACSU (EMBL:Z14225), jag, Bacillus subtilis SpoIIIJ associated protein (208 aa), fasta scores; opt: 231 z-score: 268.4 E(): 1.1e-07, 31.7% identity in 139 aa overlap, and other jag homologs e.g. TR:O53598 (EMBL:AL021426) Mycobacterium tuberculosis hypothetical protein (187 aa) (62.7% identity in 169 aa overlap).
 
    0.696
SCO2851
Putative membrane protein; SCE20.25c, possible membrane protein, len: 237 aa. Similar in parts to many bacterial inner membrane proteins e.g. Streptomyces coelicolor TR:O54569(EMBL:Y16311) inner membrane protein, STH24.05 (431 aa), fasta scores opt: 240 z-score: 285.1 E(): 1.7e-08 25.0% identity in 232 aa overlap. Contains multiple possible membrane spanning hydrophobic domains.
  
  
 0.657
SCO3883
Putative membrane protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins (By similarity).
  
  
 0.657
SCO4844
SC5G8.12, possible integral membrane protein, len: 322aa; similar to TR:O53583 (EMBL:AL022076) hypothetical protein from Mycobacterium tuberculosis (302 aa) fasta scores; opt: 937, z-score: 1058.4, E(): 0, 51.4% identity in 292 aa overlap. Contains possible membrane-spanning hydrophobic regions; Belongs to the UbiA prenyltransferase family.
  
    0.616
SCO2380
SC4A7.08, hypothetical protein, len: 273 aa; similar to TR:O53531 (EMBL:AL021925) Mycobacterium tuberculosis hypothetical 28.a kD protein MTV022.07c, 272 aa; fasta scores: opt: 1011 z-score: 1132.5 E(): 0; 56.8% identity in 271 aa overlap.
  
    0.613
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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