STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO0159SCJ1.08 putative ECF sigma factor, len: 322 aa, similar to many e.g. S. coelicolor TR:CAB44418 (EMBL:AL078610) putative ECF sigma factor SCH35.09 (223 aa) fasta scores, opt: 656 z-score: 777.0 E(): 0 64.6% identity in 175 aa overlap and Mycobacterium tuberculosis SIGI protein TR:O50445 (EMBL; AL010186)(290 aa), fasta scores opt: 385 z-score: 458.0 E(): 3.7e-18 30.0% identity in 290 aa overlap. Contains a Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). Possible helix-turn-helix motif between 142-163 aa, score +4.11 SD. (322 aa)    
Predicted Functional Partners:
SCO0158
SCJ1.07, probable oxidoreductase, len: 409 aa; similar to e.g. Synechocystis sp. (strain PCC 6803) TR:P73735 (EMBL:D90909) NADH dehydrogenase (404 aa), fasta scores opt: 358 z-score: 399.1 E(): 7.1e-15 28.9% identity in 353 aa overlap and Rhodococcus globerulus TR:Q57031(EMBL:X80041) ferredoxin reductase BPH (412 aa), fasta scores opt:294 z-score: 328.8 E(): 5.9e-11 31.3% identity in 358 aa overlap.
 
     0.853
SCO0157
Hypothetical protein SCJ1.06; SCJ1.06, doubtful CDS, len: 125 aa.
       0.762
SCO5217
Anti-sigma factor; A redox-regulated anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigR, and a key sensor of disulfide stress. Holds SigR, its cognate ECF sigma factor, in an inactive form, inhibiting its sigma activity under reducing but not oxidizing conditions; oxidation and reduction of the anti-sigma factor is reversible. Mycothiol (MSH) is competent for reduction of RsrA, allowing it to bind to SigR. In conjunction with its cognate sigma factor SigR may sense the intracellular level of reduced MSH. Probably releases SigR during oxidative stress.
  
 
 0.727
SCO5216
RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by an anti-sigma factor (RsrA) until released. Responds to thiol-oxidative stress, involved in regulation of about 30 genes and operons, including the thioredoxin system (trxB-trxA, trxC), ribosomal protein L31, RNA polymerase-binding protein RbpA and mycothiol (MSH) biosynthetic (mshA) and recycling genes (mca). In conjunction with its cognate anti-s [...]
      
 0.645
SCO5243
2SC7G11.05c, sig1, RNA polymerase sigma factor, len: 361 aa; identical to previously sequenced TR:Q9RIT0 (EMBL:AJ249450) Streptomyces coelicolor A3(2) Sig1 protein, 361 aa and similar TR:CAB93744 (EMBL:AL357613) Streptomyces coelicolor regulatory protein SC5F8.16c, 83 aa; fasta scores: opt: 414 z-score: 534.4 E(): 3.9e-24; 72.0% identity in 82 aa overlap. Contains Pfam match to entry PF00140 sigma70, Sigma-70 factor and possible helix-turn-helix motif at residues 326..347 (+7.10 SD).
      
 0.517
SCO1513
GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp. PppGpp could play an essential role in triggering antibiotic production under some nutritional conditions; Belongs to the RelA/SpoT family.
   
  
 0.495
SCO5820
Major vegetative sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. Its activity is stimulated by RbpA.
   
  
 0.492
SCO4005
2SC10A7.09, probable RNA polymerase sigma factor, len: 157 aa; similar to SW:RPOE_STRCO (EMBL:L29636) Streptomyces coelicolor RNA polymerase sigma-E factor SigE, 176 aa; fasta scores: opt: 451 z-score: 556.7 E(): 1.7e-23; 48.7% identity in 150 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily) and possible helix-turn-helix motif at residues 120..141 (+3.36 SD).
  
   
 0.450
SCO2953
SCE59.12c, possible membrane protein, len: 262 aa; similar to TR:CAB63193 (EMBL:AL133469) Streptomyces coelicolor putative membrane protein SCM10.32, 216 aa; fasta scores: opt: 204 z-score: 218.0 E(): 9.9e-05; 37.2% identity in 253 aa overlap. Contains possible hydrophobic membrane spanning region.
  
 
 0.449
SCO0156
Hypothetical protein SCJ1.05c; SCJ1.05c, doubtful CDS, len: 125 aa.
       0.446
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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