STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO0237SCJ9A.16, possible oxidoreductase, len: 253 aa; similar to many proposed oxidoreductases e.g. SW:DLTE_BACSU from Bacillus subtilis (252 aa) fasta scores; opt: 368, z-score: 429.4, E(): 1.5e-16, (33.2% identity in 205 aa overlap). Contains Pfam match to entry PF00106 adh_short, short chain dehydrogenase and Prosite match to PS00061 Short-chain dehydrogenases/reductases family signature. (253 aa)    
Predicted Functional Partners:
SCO0236
SCJ9A.15c, possible DNA-binding protein, len: 290 aa; prediction based on GC Frameplot, Hidden Markov Model and amino acid usage. Similar to TR:CAC44562 (EMBL:AL596144) Streptomyces coelicolor putative DNA-binding protein SCBAC12C8.07c, 284 aa; fasta scores: opt: 636 Z-score: 730.2 E(): 4.9e-33; 43.060% identity in 281 aa overlap. Contains possible helix-turn-helix motif (+3.31 SD) residues 39-60.
 
     0.639
SCO2476
SC7A8.15c, probable dehydrogenase/reductase (putative secreted protein), len: 247 aa; similar to TR:CAB52925 (EMBL:AL109949) Streptomyces coelicolor putative oxidoreductase SCJ11.40, 250 aa; fasta scores: opt: 591 z-score: 665.9 E(): 1.1e-29; 43.1% identity in 246 aa overlap and to SW:2BHD_STREX AC:P19992 Streptomyces exfoliatus (Streptomyces hydrogenans) 20-beta-hydroxysteroid dehydrogenase (EC 1.1.1.53), 25 aa; fasta scores: opt: 414 z-score: 469.7 E(): 9e-19; 36.1% identity in 249 aa overlap. Contains Pfam match to entry PF00106 adh_short, short chain dehydrogenase and PF00678 adh_s [...]
  
     0.628
SCO0970
SCM11.25c, probable dehydrogenase/reductase (putative secreted protein), len: 244 aa; similar to TR:CAB52925 (EMBL:AL109949) Streptomyces coelicolor putative oxidoreductase SCJ11.40, 250 aa; fasta scores: opt: 526 z-score: 621.9 E(): 2.9e-27; 42.1% identity in 242 aa overlap and to SW:DHG3_BACME (EMBL:D10625) Bacillus megaterium glucose 1-dehydrogenase III (EC 1.1.1.47) GdhIII, 261 aa; fasta scores: opt: 430 z-score: 509.8 E(): 5.1e-21; 36.4% identity in 247 aa overlap. Contains Pfam matches to entries PF00106 adh_short, short chain dehydrogenase and PF00678 adh_short_C2, Short chain d [...]
  
     0.621
SCO4486
SCD69.06, hypothetical protein, len: 135 aa; similar to TR:Q9Z549 (EMBL:AL035212) Streptomyces coelicolor putative quinone protein SC9B2.10c, 130 aa; fasta scores: opt: 191 z-score: 257.8 E(): 6.8e-07; 34.6% identity in 127 aa overlap and to TR:Q98IY9 (EMBL:AP002999) Rhizobium loti (Mesorhizobium loti) MLR2185 protein, 133 aa; fasta scores: opt: 522 Z-score: 639.6 E(): 5.4e-28; 64.122% identity in 131 aa overlap.
  
     0.578
SCO0111
SCJ11.40, probable oxidoreductase, len: 753 aa; similar to many egs. TR:O32457 (EMBL:D87924) ORF7 from the putative polyketide synthase cluster of Actinomadura hibisca (246 aa) fasta scores; opt: 480, z-score: 498.5, E(): 2.1e-20, (38.3% identity in 248 aa overlap) and TR:Q54810 (EMBL:L35560) reductase from the doxorubicin polyketide synthase cluster of Streptomyces peucetius (251 aa) fasta scores; opt: 408, z-score: 425.7, E(): 2.4e-16, (33.7% identity in 243 aa overlap). Contains Pfam matches to entry PF00106 adh_short, short chain dehydrogenase and to entry PF00678 adh_short_C2, Sho [...]
  
     0.564
SCO0737
3SC5B7.15c, probable oxidoreductase, len: 266 aa; similar to SW:FABG_HAEIN (EMBL:U32701) Haemophilus influenzae 3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100) FabG, 242 aa; fasta scores: opt: 510 z-score: 584.5 E(): 4.9e-25; 41.4% identity in 239 aa overlap. Contains Pfam match to entry PF00106 adh_short, short chain dehydrogenase and PF00678 adh_short_C2, Short chain dehydrogenase/reductase C-terminus.
  
     0.555
SCO2651
SC8E4A.21c, possible dehydrogenase/reductase (putative secreted protein), len: 245 aa; similar to TR:CAB52925 (EMBL:AL109949) Streptomyces coelicolor putative oxidoreductase SCJ11.40, 250 aa; fasta scores: opt: 717 z-score: 778.8 E(): 0; 47.6% identity in 250 aa overlap and to SW:LINX_PSEPA (EMBL:D23722) Pseudomonas paucimobilis 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase (EC 1.1.-.-) LinX, 250 aa; fasta scores: opt: 446 z-score: 488.9 E(): 8e-20; 34.3% identity in 248 aa overlap. Contains Pfam matches to entries PF00106 adh_short, short chain dehydrogenase and PF00678 adh_s [...]
  
     0.554
SCO2331
SCC53.22c, possible MarR-family transcriptional regulator, len: 137 aa; similar to many e.g. SW:Q10810 (YX18_MYCTU) hypothetical transcriptional regulator CY274.18 from Mycobacterium tuberculosis (139 aa) fasta scores; opt: 145, z-score: 193.6, E(): 0.0026, 28.9% identity in 128 aa overlap and SW:P42195 (PECS_ERWCH) regulatory protein PecS from Erwinia chrysanthemi (166 aa) fasta scores; opt: 109, z-score: 148.4, E(): 0.86, 25.6% identity in 129 aa overlap. Contains Pfam match to entry PF01047 MarR, MarR family.
  
     0.497
SCO7363
Putative oxidoreductase; SC9H11.17c, possible oxidoreductase, len: 263 aa. Almost identical to the previously sequenced: Streptomyces coelicolor TR:BAA82699EMBL:AB017438) Orf2 (263 aa). Also highly similar to Pseudomonas paucimobilis SW:LINC_PSEPA(EMBL:D14595) 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase (EC 1.1.-.-) LinC (250 aa), fasta scores opt: 580 z-score: 605.0 E(): 3.1e-26 42.5% identity in 252 aa overlap and Streptomyces coelicolor TR:O88068(EMBL:AL031541) putative dehydrogenase, SCI35.33C (260 aa), fasta scores opt: 584 z-score: 608.8 E(): 1.9e-2 43.8% identity in 2 [...]
  
     0.466
SCO1803
SCI33.02, possible oxidoreductase, len: 231 aa; similar to TR:Q9KAS7 (EMBL:AP001514) Bacillus halodurans 3-oxoacyl-(acyl-carrier-protein) reductase BH2210, 244 aa; fasta scores: opt: 369 z-score: 399.8 E(): 1e-14; 35.3% identity in 235 aa overlap. Contains Pfam match to entry PF00106 adh_short, short chain dehydrogenase and match to Prosite entry PS00061 Short-chain dehydrogenases/reductases family signature; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  
     0.437
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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