STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO0249SCJ9A.28c, possible monooxygenase, len: 504 aa; similar to many e.g. TR:Q9ZGM8 (EMBL:AF077869) oxygenase involved in the last step of mithramycin biosynthesis in Streptomyces argillaceus (533 aa) fasta scores; opt: 1215, z-score: 1311.5, E(): 0, (45.0% identity in 513 aa overlap). Contains Pfam matches to entry PF01360 Monooxygenase, Monooxygenase and Pfam match to entry PF01494 FAD_binding_3, and Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains possible uncleavable N-terminal signal sequence. (504 aa)    
Predicted Functional Partners:
SCO0250
SCJ9A.29, possible transcriptional regulator, len: 221aa; similar to many tetR-family transcriptional regulators eg. SW:TER1_ECOLI TetR from Tn1721 of Escherichia coli (216 aa) fasta scores; opt: 429, z-score: 484.8, E(): 1.2e-19, (40.7% identity in 209 aa overlap). Contains possible helix-turn-helix motif (+4.13 SD) 37-58aa.
 
     0.719
SCO0248
Hypothetical protein; SCJ9A.27c, unknown, len: 195aa; prediction based on Hidden Markov Model and amino acid usage.
       0.686
SCO7769
SC5E9.17, conserved hypothetical protein, len: 280 aa; similar to many e.g. TR:O31512 (EMBL:Z99107) hypothetical protein from Bacillus subtilis (286 aa) fasta scores; opt: 651, z-score: 727.7, E(): 0, 38.1% identity in 278 aa overlap.
  
    0.479
SCO1007
2SCG2.20c, possible oxidoreductase, len: 380 aa; similar to TR:O54177 (EMBL:AL021411) Streptomyces coelicolor putative oxidoreductase SC7H1.18, 397 aa; fasta scores: opt: 842 z-score: 944.5 E(): 0; 41.6% identity in 368 aa overlap. Contains Pfam matches to entries PF01494 FAD_binding_3, FAD binding domain and PF01360 Monooxygenase, Monooxygenase.
  
     0.456
SCO6827
SC4A9.04c, polyketide synthase, len: 2358 aa. Highly similar to many including: Stigmatella aurantiaca TR:AAF19813(EMBL:AF188287) polyketide synthase, MtAE, found within the Myxothiazol biosynthetic gene cluster (1947 aa), fasta scores opt: 2671 z-score: 2436.5 E():0 35.8% identity in 1770 aa overlap and Mycobacterium tuberculosis SW:PPSA_MYCTU(EMBL:Z74697) phenolpthiocerol synthesis polyketide synthase gene, PpsA (1876 aa), fasta scores opt: 2221 z-score: 2025.5 E(): 0 33.6% identity in 1761 aa overlap. Contains Prosite hits to PS00606 Beta-ketoacyl synthases active site and 2xPS00012 [...]
 
 
 0.452
SCO0699
Hypothetical protein SCF42.09c; SCF42.09c, unknown, len: 97 aa.
  
    0.444
SCO0801
Putative cytochrome P450; SCF43.12, possible cytochrome P450, len: 527 aa. Highly similar to the N-terminal P450 domain of Bacillus megaterium SW:CPXB_BACME (EMBL:J04832) cytochrome P450(BM-3) (1048 aa), fasta scores opt: 789 z-score: 839.8 E():0 41.9% identity in 497 aa overlap. Also weakly similar to Eukaryotic cytochrome P450 proteins e.g. Homo sapiens (Human) SW:CPF3_HUMAN(EMBL:D12620) cytochrome P450 4F3 (leukotriene-B4 20-monooxygenase) (EC 1.14.13.30) (520 aa), fasta scores opt: 553 z-score: 592.7 E(): 1.2e-25 29.2% identity in 390 aa overlap. Contains Pfam match to entry PF0006 [...]
  
   0.422
SCO3245
SCE29.14c, possible salicylate hydroxylase (putative secreted protein), len: 420 aa; similar to many e.g. TR:P96555 (EMBL:AB000564) salicylate hydroxylase from Sphingomonas sp. AJ1 (395 aa) fasta scores; opt: 830, z-score: 827.2, E(): 0, (41.9% identity in 320 aa overlap) and TR:G4104775 (EMBL:AF039534) salicylate hydroxylase from Pseudomonas stutzeri strain AN10 (389 aa) fasta scores; opt: 707, z-score: 706.0, E(): 5.1e-32, (34.7% identity in 401 aa overlap). Contains Pfam match to entry PF01360 Monooxygenase, Monooxygenase, score 91.00, E-value 2.4e-23. Contains possible N-terminal r [...]
  
     0.416
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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