STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO0309SC5G9.18c, probable amide hydrolase, len: 362 aa; similar to 6-aminohexanoate-dimer hydrolases which degrade N-(6-aminohexanoyl)-6-aminohexanoate e.g. TR:P75007 (EMBL:K02336), NylB', Flavobacterium sp. (strain K172) 6-aminohexanoic acid linear oligomer hydrolase (EII') (392 aa), fasta scores; opt: 531 z-score: 598.0 E(): 6.1e-26, 34.1% identity in 323 aa overlap. (362 aa)    
Predicted Functional Partners:
SCO0310
SC5G9.19c, possible tetR-family transcriptional regulator, len: 141 aa; shows similarity to the N-terminal half of TR:O24741 (EMBL:AB001683), FarA, Streptomyces sp. strain FRI-5 receptor for an extracellular regulatory factor (IM-2) (221 aa), fasta scores; opt: 154 z-score: 193.4 E(): 0.0021, 36.7% identity in 79 aa overlap and to putative transcriptional regulators. Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family.
 
     0.539
SCO3319
Putative glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
      
 0.483
SCO1698
Conserved hypothetical protein; SCI30A.19, unknown, len: 153 aa; similar to many of undefined function e.g. TR:P96807 (EMBL:Z92770) hypothetical protein from Mycobacterium tuberculosis (151 aa) fasta scores; opt: 639, z-score: 785.9, E(): 0, (60.8% identity in 148 aa overlap) and SW:NODN_RHILV nodulation protein from Rhizobium leguminosarum (161 aa) fasta scores; opt: 388, z-score: 482.2, E(): 1.6e-19, (44.8% identity in 145 aa overlap).
 
     0.464
SCO0044
SCJ4.25c, probable oxidoreductase, len: 222 aa; similar to many e.g. SW:NOX_THETH NADH dehydrogenase from Thermus thermophilus (205 aa) fasta scores; opt: 169, z-score: 215.5, E(): 0.00012, (27.7% identity in 220 aa overlap). Contains Pfam match to entry PF00881 Nitroreductase, Nitroreductase family.
  
     0.431
SCO0314
SC5G9.23, putative secreted protein, len: 648 aa; unknown function, similar to TR:Q52556 (EMBL:M86744), SdsA, Pseudomonas sp. alkyl sulfatase which degrades sulfate esters of long-chain primary alcohols (SDS) (528 aa), fasta scores; opt: 739 z-score: 806.7 E(): 0, 29.7% identity in 528 aa overlap, but having an N-terminal extension of approx. 140 aa. Similar to TR:Q48790 (EMBL:X92423), SepA, Listeria monocytogenes gene implicated in cell separation (391 aa) (42.6% identity in 364 aa overlap). Also similar to hypothetical proteins e.g. TR:O69728 (EMBL:AL022121) Mycobacterium tuberculosi [...]
 
     0.404
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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