STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO0466SCF76.06, probable araC family transcriptional regulator, len: 327 aa. Highly similar to many including the Streptomyces coelicolor hypothetical regulators: TR:CAB40696 (EMBL; AL049587) SC5F2A.29 (325 aa), fasta scores opt: 857 z-score: 962.2 E():0 45.8% identity in 323 aa overlap and TR:CAB46927 (EMBL; AL096822) SCGD3.05 (334 aa), fasta scores opt: 617 z-score: 694.7 E(): 2.4e-31 38.6% identity in 332 aa overlap. In addition to Streptomyces lividans SW:YCP1_STRLI (EMBL; U02635) hypothetical protein in CPOL 5'region (ORF1) (fragment) (141 aa), fasta scores opt: 908 z-score: 1024.0 E(): [...] (327 aa)    
Predicted Functional Partners:
SCO0467
Conserved hypothetical protein SCF76.07; SCF76.07, unknown, len: 247 aa; similar to TR:Q98LL0 (EMBL:AP002996) MLR0982 protein from Rhizobium loti (Mesorhizobium loti) (215 aa) fasta scores; opt: 410, Z-score: 484.9, E(): 2.2e-19, 33.178% identity (33.649% ungapped) in 214 aa overlap.
 
     0.822
SCO3048
SCBAC19G2.03c, possible membrane protein, len: 397aa: similar to TR:O69850 (EMBL:AL023702) putative transcriptional regulator from Streptomyces coelicolor (366 aa) fasta scores; opt: 615, Z-score: 578.6, 34.694% identity (37.072% ungapped) in 343 aa overlap. Contains possible membrane-spanning hydrophobic region. Also has region of similarity with adjacent CDS SCBAC19F3.02.
   
    0.723
SCO1926
SCC22.08c, possible DNA-binding protein, len: 252aa; similar to TR:O53151 (EMBL:AL021184) hypothetical protein from Mycobacterium tuberculosis (278 aa) fasta scores; opt: 629, z-score: 705.6, E(): 5.8e-32, (46.8% identity in 233 aa overlap). Contains a helix-turn-helix motif (+4.75 SD) at residues 34-55.
   
  
 0.675
SCO7815
SC8E7.12 possible TetR-family transcriptional regulator, len: 223 aa. Highly similar to many putative regulators e.g. Mycobacterium tuberculosis TR:O53737 (EMBL:AL021932) putative transcriptional regulator (236 aa), fasta scores opt: 471 z-score: 574.1 E(): 1.7e-24 39.0% identity in 218 aa overlap. Contains a Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family with a putative helix-turn-helix motif situated between residues 44..65 (+4.94 SD).
   
  
 0.674
SCO1504
SC9C5.28, putative regulator, len: 750 aa; similar to TR:O53720 (EMBL:AL021931) Mycobacterium tuberculosis transcriptional regulatory protein MTV036.21, 1085 aa; fasta scores: opt: 975 z-score: 1090.3 E(): 0; 34.3% identity in 724 aa overlap. Contains match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop).
  
    0.665
SCO7307
SC5F8.17c, possible LysR-family transcriptional regulator, len: 300 aa. Similar to many other LysR-family proteins including: Corynebacterium glutamicum SW:LYSG_CORGL (EMBL:X96471) lysine export transcriptional regulatory protein, LysG (290 aa), fasta scores opt: 780 z-score: 918.3 E():0 44.5% identity in 290 aa overlap and Escherichia coli SW:ICIA_ECOLI (EMBL:M62865) chromosome initiation inhibitor, IciA (297 aa), fasta scores opt: 538 z-score: 635.6 E(): 6.2e-28 37.1% identity in 291 aa overlap. Contains a Prosite hit to PS00044 Bacterial regulatory proteins, lysR family signature an [...]
   
    0.631
SCO5413
SC8F4.17, possible transcriptional regulator, len: 169 aa; similar to many proposed transcriptional regulators e.g. TR:CAB62730 (EMBL:AL133423) putative MarR-family transcriptional regulator from Streptomyces coelicolor (151 aa) fasta scores; opt: 184, z-score: 242.7, E(): 4.1e-06, 35.1% identity in 111 aa overlap. Contains Pfam match to entry PF01047 MarR, MarR family.
   
    0.620
SCO5325
SC6G9.08c, hypothetical protein, len: 106 aa; unknown function, improbable CD suggested by GC frameplot. C-terminus is proline-rich and overlaps with hypothetical CDS on opposite strand.
   
    0.614
SCO6223
SC2H4.05, unknown, len: 216 aa; similar to hypothetical proteins from many organisms e.g. TR:P71983 (EMBL:Z81360) Mycobacterium tuberculosis MTCY04C12.10C (236 aa), fasta scores; opt: 276 z-score: 307.9 E(): 6.6e-10, 46.0% identity in 100 aa overlap.
   
    0.614
SCO0452
Putative SIR2-like regulatory protein; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class II subfamily.
   
    0.610
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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