STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO0476SCF76.16, ABC transport protein, ATP-binding subunit, len: 252 aa. Similar to many e.g. Haemophilus influenzae SW:FECE_HAEIN (EMBL; U32720) iron(III) dicitrate transport ATP-binding protein FecE homolog (306 aa), fasta scores opt: 375 z-score: 413.4 E(): 1.2e-15 37.3% identity in 185 aa overlap. Contains a Prosite hit to PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). (252 aa)    
Predicted Functional Partners:
SCO0475
SCF76.15c, probable ABC transporter protein, integral membrane subunit, len: 283 aa. Similar to many e.g. Escherichia coli SW:ZNUB_ECOLI (EMBL; AE000280) high-affinity zinc uptake system membrane protein ZnuB (261 aa), fasta scores opt: 442 z-score: 483.2 E(): 1.5e-19 32.5% identity in 246 aa overlap. Contains a Pfam match to entry PF00950 ABC-3, ABC 3 transport family and multiple possible membrane spanning hydrophobic domains.
 
 0.997
SCO0473
SCF76.13c, possible solute-binding lipoprotein, len: 329 aa. Similar to many e.g. Streptococcus parasanguis SW:ADHS_STRPA (EMBL; M26130) adhesin B precursor (saliva-binding protein) (309 aa), fasta scores opt: 354 z-score: 399.1 E(): 7.2e-15 23.7% identity in 317 aa overlap. Contains an appropriately positioned Prosite hit to PS00013 Prokaryotic membrane lipoprotein lipid attachment site, a Pfam match to entry PF01297 Lipoprotein_4, Adhesion lipoprotein and a possible N-terminal signal sequence.
 
  
 0.985
SCO2507
SCC121.10, probable metal transport ABC transporter, len: 300 aa; similar to TR:Q9XDA5 (EMBLAF104349:) Listeria monocytogenes hydrophobic membrane protein ZurM, 295aa fasta scores: opt: 608 z-score: 697.8 E(): 1.8e-31; 34.7% identity in 288 aa overlap and to SW:ZNUB_ECOLI (EMBL:AE000280) Escherichia coli high-affinity Zinc uptake system membrane protein ZnuB, 261 aa; fasta scores: opt: 397 z-score: 459.6 E(): 3.3e-18; 27.3% identity in 245 aa overlap. Contains Pfam match to entry PF00950 ABC-3.
 
 0.977
SCO0474
SCF76.14c, possible lipoprotein, len: 415 aa. Contains an appropriately positioned Prosite hit to PS00013 Prokaryotic membrane lipoprotein lipid attachment site and a possible N-terminal signal sequence.
 
  
 0.922
SCO0472
SCF76.12c, possible secreted protein, len: 384 aa. Contains a possible N-terminal signal sequence.
 
  
 0.882
SCO2505
SCC121.08, probable ABC-transporter metal-binding lipoprotein, len: 328 aa; similar to TR:O05703 (EMBL:Z71552) Streptococcus pneumoniae AdcA protein (fragment), 423 aa; fasta scores: opt: 551 z-score: 603.5 E(): 3.2e-26; 39.7% identity in 305 aa overlap and to SW:ZNUA_ECOLI (EMBL:U38702) Escherichia coli, high-affinity zinc uptake system protein ZnuA precursor ZnuA, 328 aa; fasta scores: opt: 294 z-score: 327.0 E(): 8e-11; 26.5% identity in 283 aa overlap. Contains Pfam match to entry PF01297 Lipoprotein_4 and match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attach [...]
 
  
 0.860
SCO2550
Putative lipoprotein; SCC77.17c, possible lipoprotein, len: 171 aa. Contains an appropriately positioned Prosite hit to PS00013 Prokaryotic membrane lipoprotein lipid attachment site and a possible N-terminal signal sequence.
  
  
 0.754
SCO2506
SCC121.09, probable metal transport ABC transporter, len: 256 aa; similar to TR:Q9XDA6 (EMBL:AF104349) Listeria monocytogenes ABC transporter ZurA, 257aa; fasta scores: opt: 468 z-score: 522.7 E(): 1e-21; 38.0% identity in 237 aa overlap and to SW:FHUC_ECOLI (EMBLX05810:) Escherichia coli ferrichrome transport ATP-binding protein FhuC, 265 aa; fasta scores: opt: 416 z-score: 465.6 E(): 1.5e-18; 34.8% identity in 256 aa overlap. Contains Pfam match to entry PF00005 ABC_tran and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop).
  
  
 
0.634
SCO7459
SC5C11.16c, possible ABC transporter protein, ATP-binding component, len: 279 aa. Highly similar to several transporters e.g. Escherichia coli SW:FEPC_ECOLI(EMBL:X57471) ferric enterobactin transport ATP-binding protein, FepC (271 aa), fasta scores opt: 408 z-score: 486.3 E(): 1.1e-19 35.2% identity in 244 aa overlap and Streptomyces coelicolor TR:Q9X9Z4(EMBL:AL079332) putative ABC transporter ATP-binding protein, SCI5.06c (265 aa), fasta scores opt: 666 z-score: 788.8 E():0 44.2% identity in 260 aa overlap. Contains Prosite hits to PS00017 ATP/GTP-binding site motif A (P-loop)and PS00 [...]
  
  
 
0.626
SCO5958
Cobalt transport system ATP binding protein; Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity).
  
  
0.610
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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