STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
SCO0548SCF11.28c, fabB2, possible 3-oxoacyl-(acyl-carrier-protein) synthase, len: 428 aa; similar to TR:Q54208 (EMBL:L43074) Streptomyces glaucescens fabB, 423 aa; fasta scores: opt: 1375 z-score: 1459.4 E(): 0; 52.1% identity in 420 aa overlap. Contains Pfam match to entry PF00109 ketoacyl-synt, beta-ketoacyl synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (428 aa)    
Predicted Functional Partners:
SCO2387
SC4A7.15, fabD, malonyl CoA:acyl carrier protein malonyltransferase, len: 316 aa; identical to previously sequenced TR:P72391 (EMBL:X86475) Streptomyces coelicolor malonyl CoA:acyl carrier protein malonyltransferase, FabD, 316 aa and similar to SW:FABD_ECOLI (EMBL:M87040) Escherichia coli malonyl CoA-acyl carrier protein transacylase (EC 2.3.1.39) FabD, 308 aa; fasta scores: opt: 524 z-score: 551.4 E(): 2.5e-23; 36.8% identity in 315 aa overlap. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain.
 
 0.992
SCO2445
SCC24.16, probable acetyl CoA carboxylase (alpha and beta subunits), len: 458 aa; N-terminal region similar to SW:ACCD_ECOLI (EMBL:M32445) Escherichia coli acetyl-Coenzyme A carboxylase carboxyl transferase subunit beta (EC 6.4.1.2) AccD, 304 aa; fasta scores: opt: 368 z-score: 366.2 E(): 5.8e-13; 32.4% identity in 238 aa overlap and C-terminal region similar to TR:AAF10787 (EMBL:AE001970) Deinococcus radiodurans acetyl-CoA carboxylase carboxyl transferase alpha subunit DR1214, 316 aa; fasta scores: opt: 366 z-score: 364.0 E(): 7.7e-13; 39.9% identity in 223 aa overlap.
 
  
 0.976
SCO0547
SCF11.27c, possible acyltransferase, len: 333 aa; similar to TR:CAB52353 (EMBL:AL109747) Streptomyces coelicolor putative multi-domain beta keto-acyl synthase, 2082 aa; fasta scores: opt: 402 z-score: 416.4 E(): 8e-16; 32.5% identity in 329 aa overlap, and to TR:Q55226 (EMBL:L34880) Streptomyces sp. acyltransferase DauA, 338 aa; fasta scores: opt: 326 z-score: 349.0 E(): 4.5e-12; 33.4% identity in 326 aa overlap. Contains Pfam match to entry PF00698 acyl_transf, acyl transferase domain.
 
 
 0.974
SCO1271
2SCG18.18c, fabH3, probable 3-oxoacyl-[acyl-carrier-protein] synthase III, len: 317 aa; similar to TR:FABH_ECOLI (EMBL:M77744) Escherichia coli 3-oxoacyl-[acyl-carrier-protein] synthase III (KASIII) FabH, 317 aa; fasta scores: opt: 526 z-score: 548.1 E(): 4.8e-23; 30.2% identity in 318 aa overlap and to TR:Q9ZBV4 (EMBL:AL034443) Streptomyces coelicolor FabH2, 3-oxoacyl-[acyl-carrier-protein] synthase IIe SC4B5.14, 316 aa; fasta scores: opt: 701 z-score: 636.7 E(): 7.2e-30; 38.7% identity in 323 aa overlap.
 
 
 0.952
SCO6564
3-oxoacyl-[acyl-carrier-protein] synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family.
 
 
 0.951
SCO2388
3-oxoacyl-[acyl-carrier-protein] synthase III; Essential enzyme that catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family.
 
 
 0.950
SCO3246
Putative 3-oxoacyl-[acyl carrier protein] synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family.
 
 
 0.948
mmyC
Putative acyl carrier protein synthase, MmyC; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family.
 
 
 0.946
SCO1815
Probable 3-oxacyl-(acyl-carrier-protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
 
 0.921
SCO6717
SC4C6.27c, probable acyl-[acyl-carrier protein] desaturase, len: 328 aa; similar to many e.g. SW:STAD_LINUS (EMBL:X70962) Linum usitatissimum stearoyl-ACP desaturase (396 aa), fasta scores; opt: 385 z-score: 461.5 E(): 2.2e-18, 30.2% identity in 311 aa overlap. The N-terminal 100 aa are divergent. Highest similarity to TR:Q50050 (EMBL:U15182), aadX, Mycobacterium leprae protein (338 aa) (45.5% identity in 325 aa overlap) and TR:Q50824 (EMBL:AL022004), des, Mycobacterium tuberculosis protein (338 aa) (46.1% identity in 323 aa overlap). Contains TTA (leucine) codon, possible target for b [...]
   
 
 0.906
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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