STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO0748SCF81.07, possible hydrolase, len: 193 aa; similar to TR:P94573 (EMBL:Z82987) Bacillus subtilis hypothetical 21.1KD protein, 189 aa; fasta scores: opt: 504 z-score: 582.8 E(): 4.4e-25; 48.4% identity in 190 aa overlap and to SW:ENTB_ECOLI (EMBL:M24148) Escherichia coli isochorismatase (EC 3.3.2.1) (2,3 dihydro-2,3 dihydroxybenzoate synthase) EntB, 285 aa; fasta scores: opt: 205 z-score: 242.1 E(): 4.1e-06; 26.8% identity in 183 aa overlap. Contains match to Pfam entry PF00857 Isochorismatase, Isochorismatase family. (193 aa)    
Predicted Functional Partners:
SCO0447
SCF51A.25, possible MarR-family regulatory protein, len: 148 aa. Similar to many hypothetical proteins with similarity to the MarR family of transcriptional regulators e.g. Mycobacterium tuberculosis SW: YZ08_MYCTU (EMBL; Z73101) hypothetical 15.6 KD protein CY31.08 (143 aa), fasta scores opt: 256 z-score: 328.8 E(): 5.9e-11 34.1% identity in 135 aa overlap. Contains a Pfam match to entry PF01047 MarR, MarR family.
 
     0.714
SCO0747
SCF81.06c, hypothetical protein, len: 166 aa; similar to various hypothetical proteins, e.g. TR:AAD36153 (EMBL:AE001768) Thermotoga maritima conserved hypothetical protein TM1076, 157 aa; fasta scores: opt: 293 z-score: 385.9 E(): 4e-14; 39.1% identity in 133 aa overlap and to TR:Q9CCZ0 (EMBL:AL583926) Mycobacterium leprae conserved hypothetical protein ML 2654, 165 aa; fasta scores: opt: 642 Z-score: 785.7 E(): 4e-36; 60.248% identity in 161 aa overlap.
  
    0.674
SCO6556
SC4B5.06, possible transmembrane protein, similar to SW:YFEH_ECOLI Hypothetical protein from Escherichia coli, (332 aa), fasta scores; opt: 985, z-score: 1173.2, E(): 0, (48.9% identity in 323 aa overlap). Hydrophobic with several possible membrane spanning regions.
 
     0.654
SCP1.88c
SCP1.88c, possible hydrolase, len: 193aa; weakly similar to many eg. TR:Q9X8G0 (EMBL:AL049819) putative hydrolase from Streptomyces coelicolor (193 aa) fasta scores; opt: 177, z-score: 224.6, E(): 4.8e-05, 30.7% identity in 153 aa overlap and SW:O07900 (VIBB_VIBCH) vibriobactin-specific isochorismatase (EC 3.3.2.1) (293 aa) fasta scores; opt: 163, z-score: 205.0, E(): 0.0006, 23.9% identity in 180 aa overlap. Contains Pfam match to entry PF00857 Isochorismatase, Isochorismatase family.
  
     0.615
SCO5073
SCBAC20F6.16, ORF2, possible oxidoreductase, len: 329 aa; identical to previously sequenced TR:Q53927 (EMBL:X62373) Streptomyces coelicolor genes for hydroxylacyl-CoA dehydrogenase ORF2, 329 aa. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases and match to Prosite entry PS01162 Quinone oxidoreductase / zeta-crystallin signature.
  
    0.583
SCO6411
SC3C8.30, probable hydrolase, len: 280 aa; similar to e.g. BUP_RAT beta-ureidopropionase (EC 3.5.1.6) (beta-alanine synthase) (393 aa), fasta scores; opt: 529 z-score: 700.2 E(): 9.2e-32, 37.2% identity in 296 aa overlap. Also highly similar to TR:E1292351 (EMBL:AL023496) putative hydrolase SC1A6.03, fasta scores; E(): 0, 72.1% identity in 280 aa overlap.
   
 
 0.572
SCO6412
SC1A6.01, probable aminotransferase, partial CDS, len: 190 aa; similar to many members of the class-III family of pyridoxal-phosphate-dependent aminotransferases e.g. ARGD_ANASP P54752 anabaena sp. acetylornithine aminotransferase (427 aa), fasta scores; opt: 315 z-score: 402.3 E(): 2.8e-15, 36.0% identity in 189 aa overlap. Contains Pfam matchto entry aminotran_3 PF00202, Aminotransferases class-III pyridoxal-phosphate, score 147.18; SC3C8.31, probable aminotransferase, partial CDS, len: > 270 aa; similar to many members of the class-III pyridoxal-phosphate-dependent aminotransferase [...]
  
    0.562
SCO0989
Hypothetical protein 2SCG2.02c; 2SCG2.02c, unknown, len: 134 aa.
       0.560
SCO3336
SCE7.03, possible hydrolase, len: 193aa; similar to many egs. TR:O07081 (EMBL:U93876) hypothetical protein from Bacillus subtilis (187 aa) fasta scores; opt: 370, z-score: 455.2, E(): 5e-18, (35.1% identity in 188 aa overlap) and SW:ENTB_ECOLI isochorismatase from Escherichia coli (285 aa) fasta scores; opt: 133, z-score: 168.5, E(): 0.046, (29.1% identity in 196 aa overlap). Contains Pfam match to entry PF00857 Isochorismatase, Isochorismatase family.
  
     0.528
SCO4742
Conserved hypothetical protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair o [...]
  
    0.525
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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