Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
SCO0981SCBAC19F3.08c, possible DNA-binding protein, len: 489aa: similar to many eg. TR:AAK44705 (EMBL:AE006950) putative DNA-binding protein MT0481 from Mycobacterium tuberculosis (474 aa) fasta scores; opt: 1753, Z-score: 1963.4, 56.780% identity (58.009% ungapped) in 472 aa overlap. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix and Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). (489 aa)    
Predicted Functional Partners:
SCO0982
SCBAC19F3.09, aceA, isocitrate lyase, len: 426 aa: strongly similar to many e.g. SW:O53752 (ACEA_MYCTU) isocitrate lyase from Mycobacterium tuberculosis (428 aa) fasta scores; opt: 2144, Z-score: 2405.5, 74.822% identity (75.000% ungapped) in 421 aa overlap. Contains Pfam matches to entry PF00463 ICL, Isocitrate lyase family and Prosite match to PS00161 Isocitrate lyase signature.
 
   
 0.906
SCO0996
2SCG2.09, possible lipoprotein, len: 347 aa; similar to TR:Q9K467 (EMBL:AL359215) Streptomyces coelicolor putative iron transport lipoprotein SC2H12.17, 345 aa; fasta scores: opt: 473 z-score: 540.7 E(): 1.4e-22; 39.2% identity in 339 aa overlap. Contains Pfam match to entry PF01497 Peripla_BP_2, Periplasmic binding protein, correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains possible N-terminal region signal peptide sequence.
     
 0.748
SCO0983
SCBAC19F3.10, aceB2, malate synthase, len: 530 aa; strongly similar to many e.g. SW:Q9ZH77 (MASY_STRCL) malate synthase AceB from Streptomyces clavuligerus (541 aa) fasta scores; opt: 1923, Z-score: 2204.2, 58.889% identity (61.390% ungapped) in 540 aa overlap and TR:Q9RKU9 (EMBL:AL132824) malate synthase AceB1 (StAH10.08c) from Streptomyces coelicolor (540 aa) fasta scores; opt: 1930, Z-score: 2212.2, 61.895% identity (63.090% ungapped) in 475 aa overlap. Contains Pfam match to entry PF01274 Malate_synthase, Malate synthase and Prosite match to PS00510 Malate synthase signature.
     
 0.721
SCO0980
Hypothetical protein (fragment); SCBAC19F3.07, partial CDS, len: 119aa: similar to N-terminus of many eg. SW:P49851 (YKHA_BACSU) putative acyl-CoA thioester hydrolase from Bacillus subtilis (179 aa) fasta scores; opt: 240, Z-score: 251.9, 39.815% identity (40.187% ungapped) in 108 aa overlap.
     
 0.659
SCO1000
Integrase; 2SCG2.13c, integrase, len: 370 aa; N-terminal previously sequenced and annotated as TR:Q9X468 (EMBL:AF099015) Streptomyces coelicolor integrase Int, 222 aa. Contains Pfam match to entry PF00589 Phage_integrase, Phage integrase family; Belongs to the 'phage' integrase family.
     
 0.634
SCO0979
Hypothetical protein; SCBAC19F3.06c, doubtful CDS, len: 78aa: no significant database matches.
      
 0.630
SCO0997
2SCG2.10, ftrD, Fe uptake system integral membrane protein, len: 371 aa; previously sequenced and annotated as TR:Q9X471 (EMBL:AF099015) Streptomyces coelicolor Fe uptake system integral membrane protein FtrD, 374 aa and similar to TR:CAB94639 (EMBL:AL359215) Streptomyces coelicolor putative FecCD-family membrane transport protein SC2H12.15, 368 aa; fasta scores: opt: 942 z-score: 839.0 E(): 0; 45.8% identity in 360 aa overlap. Contains Pfam match to entry PF01032 FecCD_family, FecCD transport family. Also contains possible hydrophobic membrane spanning regions.
      
 0.630
SCO0998
2SCG2.11, ftrE, Fe uptake system permease, len: 272 aa; similar to previously sequenced and annotated as TR:Q9X470 (EMBL:AF099015) Streptomyces coelicolor Fe uptake system permease FtrE, 271 aa; fasta scores:opt: 1424 z-score: 1545.2 E(): 0; 89.5% identity in 257 aa overlap and similar to TR:CAB94640 (EMBL:AL359215) Streptomyces coelicolor putative iron transport protein, ATP-binding component SC2H12.16, 258 aa; fasta scores: opt: 834 z-score: 672.9 E(): 7.8e-32; 55.4% identity in 251 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter and matches to Prosite entr [...]
      
 0.630
SCO5831
SC5B8.21c, citrate synthase-like protein, len: 421 a a; similar to citrate synthase from many organisms e.g. CIS Y_THIFE P51045 thiobacillus ferrooxidans. citrate synthase (386 aa), fasta scores; opt: 387 z-score: 460.4 E(): 1.9e-1 8, 30.2% identity in 384 aa overlap. Contains Pfam match to entry citrate_synt PF00285, Citrate synthase, score 81.00 and probable helix-turn-helix at aa 17-38 (Score 1757, +5.1 7 SD). Also similar to upstream gene SC5B8.22 (390 aa) E(): 4.5e-11, 32.8% identity in 351 aa overlap.
  
  
 0.582
SCO0999
Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.
      
 0.573
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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