STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO12432SCG1.18c, bioF, 8-amino-7-oxononanoate synthase, len: 375 aa; similar to SW:BIOF_BACSH (EMBL:M29291) Bacillus sphaericus 8-amino-7-oxononanoate synthase (EC 2.3.1.47) BioF, 389 aa; fasta scores: opt: 774 z-score: 785.6 E(): 0; 39.1% identity in 379 aa overlap. Contains Pfam match to entry PF00222 aminotran_2, Aminotransferases class-II and match to Prosite entry PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. (375 aa)    
Predicted Functional Partners:
SCO1245
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
 
 
 0.999
SCO1246
Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.
 
  
 0.998
SCO1244
Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.
  
 0.983
SCO6013
Probable 1-deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily.
   
  
 0.846
SCO6768
Probable transketolase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily.
   
  
 0.778
SCO1247
2SCG1.22, conserved hypothetical protein, len: 225 aa; similar to TR:O06547 (EMBL:Z95584) Mycobacterium tuberculosis hypothetical 23.4 kD protein MTCI65.14, 216 aa; fasta scores: opt: 500 z-score: 599.5 E(): 6.3e-26; 45.9% identity in 209 aa overlap.
  
  
 0.711
SCO6148
Hypothetical protein SC1A9.12; SC1A9.12, unknown, len: 442 aa.
  
  
 0.653
SCO6799
Threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate.; Belongs to the zinc-containing alcohol dehydrogenase family.
 
  
 0.646
SCP1.205c
Hypothetical protein; SCP1.205c, unknown, len: 841aa; weak but full length similarity to TR:O87242 (EMBL:AE001272) hypothetical protein from plasmid pMRC01 of Lactococcus lactis blastp scores; Identities = 223/824 (27%), Positives = 406/824 (49%).
   
    0.555
SCO5472
Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine.
 
 
 0.554
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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