STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO12632SCG18.10c, probable ECF-sigma factor, len: 295 aa; similar to TR:Q9RDI5 (EMBL:AL136519) Streptomyces coelicolor putative sigma factor SCC57A.13c, 315 aa; fasta scores: opt: 887 z-score: 1027.2 E(): 0; 50.5% identity in 285 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). (295 aa)    
Predicted Functional Partners:
SCO5217
Anti-sigma factor; A redox-regulated anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigR, and a key sensor of disulfide stress. Holds SigR, its cognate ECF sigma factor, in an inactive form, inhibiting its sigma activity under reducing but not oxidizing conditions; oxidation and reduction of the anti-sigma factor is reversible. Mycothiol (MSH) is competent for reduction of RsrA, allowing it to bind to SigR. In conjunction with its cognate sigma factor SigR may sense the intracellular level of reduced MSH. Probably releases SigR during oxidative stress.
  
 
 0.727
SCO3892
SCH24.14c, sigT, probable RNA polymerase sigma factor, len: 236 aa; previously sequenced as TR:O86856 (EMBL:AJ007313), SigT. Similar to other S.coelicolor putative sigma factors TR:O54163 (EMBL:AL021411) possible sigma factor (200 aa) (32.2% identity in 199 aa overlap) and SCH10.35 putative RNA polymerase sigma factor from cosmid StH10 (294 aa) (37.7% identity in 159 aa overlap). Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily), score 57.10, E-value 3.8e-13.
      
 0.696
SCO5216
RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by an anti-sigma factor (RsrA) until released. Responds to thiol-oxidative stress, involved in regulation of about 30 genes and operons, including the thioredoxin system (trxB-trxA, trxC), ribosomal protein L31, RNA polymerase-binding protein RbpA and mycothiol (MSH) biosynthetic (mshA) and recycling genes (mca). In conjunction with its cognate anti-s [...]
      
 0.693
SCO5243
2SC7G11.05c, sig1, RNA polymerase sigma factor, len: 361 aa; identical to previously sequenced TR:Q9RIT0 (EMBL:AJ249450) Streptomyces coelicolor A3(2) Sig1 protein, 361 aa and similar TR:CAB93744 (EMBL:AL357613) Streptomyces coelicolor regulatory protein SC5F8.16c, 83 aa; fasta scores: opt: 414 z-score: 534.4 E(): 3.9e-24; 72.0% identity in 82 aa overlap. Contains Pfam match to entry PF00140 sigma70, Sigma-70 factor and possible helix-turn-helix motif at residues 326..347 (+7.10 SD).
      
 0.673
SCO1264
2SCG18.11, probable hydrolase, len: 316 aa; similar to TR:CAB88827 (EMBL:AL353832) Streptomyces coelicolor putative hydrolase SCE6.23c, 294 aa; fasta scores: opt: 302 z-score: 345.4 E(): 9.3e-12; 31.5% identity in 276 aa overlap. Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold.
       0.629
SCO5820
Major vegetative sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. Its activity is stimulated by RbpA.
   
  
 0.561
SCO1262
2SCG18.09c, probable gntR-family transcriptional regulator, len: 253 aa; similar to TR:Q9RKT6 (EMBL:AL132824) Streptomyces coelicolor putative transcriptional regulator SCAH10.21, 245 aa; fasta scores: opt: 306 z-score: 352.0 E(): 4e-12; 32.0% identity in 241 aa overlap and to SW:FARR_ECOLI (EMBL:X15790) Escherichia coli fatty acyl responsive regulator (P30 protein) FarR, 240 aa; fasta scores: opt: 204 z-score: 238.2 E(): 8.7e-06; 26.2% identity in 233 aa overlap. Contains Pfam match to entry PF00392 gntR, Bacterial regulatory proteins, gntR family and possible helix-turn-helix motif a [...]
  
    0.552
SCO0600
RNA polymerase sigma factor sig8; SCF55.24, sig8, len: 266 aa; identical to previously sequenced TR:CAB55833 (EMBL:AJ249580) Streptomyces coelicolor Sig8 protein, 266 aa and similar to SW:RPOF_STRCO (EMBL:L11648) Streptomyces coelicolor RNA polymerase sigma-F factor, SigF, 287 aa; fasta scores: opt: 759 z-score: 872.2 E(): 0; 47.6% identity in 269 aa overlap and to Streptomyces coelicolor putative RNA polymerase sigma factor SC5H1.14, 295 aa; fasta scores: opt: 1265 z-score: 1335.0 E(): 0; 73.8% identity in 263 aa overlap. Contains match to Pfam entry PF00140 sigma70, Sigma-70 factor a [...]
      
 0.529
SCO1513
GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp. PppGpp could play an essential role in triggering antibiotic production under some nutritional conditions; Belongs to the RelA/SpoT family.
   
  
 0.495
SCO3202
RNA polymerase principal sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
   
  
 0.458
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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