STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO1467SCL6.24c, hypothetical protein, len: 491 aa; similar to TR:CAB71206 (EMBL:AL138538) Streptomyces coelicolor hypothetical 47.0 kD protein SC6D10.11, 452 aa; fasta scores: opt: 835 z-score: 861.3 E(): 0; 37.6% identity in 434 aa overlap. (491 aa)    
Predicted Functional Partners:
SCO1468
SCL6.25c, possible serine/threonine protein kinase, len: 774 aa; similar to TR:Q9ZBL8 (EMBL:AL035159) Mycobacterium leprae putative serine/threonine kinase MLCB1450.19c, 763 aa; fasta scores: opt: 682 z-score: 645.1 E(): 1.6e-28; 36.0% identity in 736 aa overlap and to SW:KMOS_MSVMO (EMBL:V01180) Moloney murine sarcoma virus MOS serine/threonine-protein kinase transforming protein (EC 2.7.1.-) V-MOS, 374 aa; fasta scores: opt: 230 z-score: 224.5 E(): 4.4e-05; 23.4% identity in 269 aa overlap. Contains Pfam match to entry PF00069 pkinase, Eukaryotic protein kinase domain.
 
     0.917
SCO1465
SCL6.22c, possible secreted protein, len: 401 aa; similar to TR:Q55471 (EMBL:D64006) Synechocystis sp. hypothetical 46.5 kD protein, 421 aa; fasta scores: opt: 240 z-score: 260.1 E(): 4.6e-07; 28.8% identity in 385 aa overlap. Contains possible N-terminal region signal peptide sequence.
       0.875
SCO1466
SCL6.23c, possible integral membrane protein, len: 312 aa. Contains possible hydrophobic membrane spanning regions.
       0.875
SCO2669
Hypothetical protein SC6D10.12; SC6D10.12, unknown, len: 604 aa. Glycine and proline rich. Contains Pfam match to entry PF00498 FHA, FHA domain.
 
     0.815
SCO1469
Hypothetical protein SCL6.26c; SCL6.26c, unknown, len: 701 aa. C-terminal region rich in Glycine and Alanine residues. Contains Pfam match to entry PF00089 trypsin, Trypsin.
 
     0.781
SCO2666
SC6D10.09, possible serine/threonine protein kinase, len: 903 aa; similar to TR:Q9ZBL8 (EMBL:AL035159) Mycobacterium leprae putative serine/threonine kinase MLCB1450.19c, 763 aa; fasta scores: opt: 1045 z-score: 821.3 E(): 0; 42.0% identity in 793 aa overlap and to SW:PKN2_MYXXA (EMBL:M94857) Myxococcus xanthus serine/threonine-protein kinase Pkn2 (EC 2.7.1.-), 830 aa; fasta scores: opt: 301 z-score: 243.3 E(): 3.8e-06; 28.9% identity in 433 aa overlap. Contains Pfam match to entry PF00069 pkinase, Eukaryotic protein kinase domain and match to Prosite entry PS00402 Binding-protein-depe [...]
 
    0.779
SCO2667
Hypothetical protein SC6D10.10; SC6D10.10, unknown, len: 482 aa.
 
     0.774
SCO1850
SCI8.35, possible chelatase, len: 672 aa. Highly similar to many magnesium chelatase family proteins e.g. Mycobacterium tuberculosis SW:YS50_MYCTU (EMBL: Z95207) hypothetical 67.0 KD protein (629 aa), fasta scores opt: 1941 z-score: 1746.0 E(): 0 54.7% identity in 675 aa overlap and Rhodobacter capsulatus SW:BCHI_RHOCA (EMBL: Z11165) magnesium-chelatase 38 KD subunit (Mg-protoporphyrin IX chelatase) (350 aa), fasta scores opt: 1114 z-score: 1008.8 E(): 0 52.7% identity in 332 aa overlap. Contains a Pfam match to entry PF01078 Mg_chelatase, Magnesium chelatase, subunit ChlI and a possib [...]
  
 
 0.629
SCO5277
Putative magnesium chelatase; SCCB12.01, possible ion chelatase subunit (fragment), len: >98 aa; similar to SW:BCHI_RHOCA (EMBL:Z11165) Rhodobacter capsulatus magnesium-chelatase 38 Kda subunit (MG-protoporphyrin IX chelatase) BchI, 350 aa; fasta scores: opt: 163 z-score: 216.2 E(): 0.00014; 38.1% identity in 97 aa overlap; 2SC7G11.39, possible magnesium chelatase (fragment), len: >248 aa; similar to SW:BCHI_CHLVI (EMBL:Z83933) Chlorobium vibrioforme magnesium-chelatase 38 kDa subunit (MG-protoporphyrin IX chelatase) BchI, 346 aa; fasta scores: opt: 441 z-score: 520.9 E(): 1.5e-21; 38. [...]
  
 
 0.629
SCO2665
Hypothetical protein SC6D10.08; SC6D10.08, unknown, len: 444 aa. Contains possible coiled-coil region.
 
     0.622
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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