STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO1574Hypothetical protein SCL24.10; SCL24.10, unknown, len: 222 aa. (222 aa)    
Predicted Functional Partners:
SCO1575
Putative thiamine biosynthesis lipoprotein precursor; Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.
 
  
 0.962
SCO1573
SCL24.09, possible oxidoreductase (putative membrane protein), len: 445 aa; similar to SW:XYLZ_PSEPU (EMBL:M64747) Pseudomonas putida toluate 1,2-dioxygenase subunit XylZ, 336 aa; fasta scores: opt: 236 z-score: 273.1 E(): 8.6e-08; 25.4% identity in 228 aa overlap. Contains Pfam match to entry PF00175 oxidored_fad, Oxidoreductase FAD/NAD-binding domain. Contains also possible hydrophobic membrane spanning regions.
 
     0.941
SCO1571
Hypothetical protein SCL24.07; SCL24.07, unknown, len: 195 aa.
       0.687
SCO1570
SCL24.06c, argH, argininosuccinate lyase, len: 475 aa; highly similar to SW:ARLY_CORGL (EMBL:AF049897) Corynebacterium glutamicum argininosuccinate lyase (EC 4.3.2.1) ArgH, 478 aa; fasta scores: opt: 1473 z-score: 1658.6 E(): 0; 59.1% identity in 391 aa overlap. Contains Pfam match to entry PF00206 lyase_1, Lyase and two matches to Prosite entries PS00163 Fumarate lyases signature and PS00017 ATP/GTP-binding site motif A (P-loop).
       0.628
SCO1572
SCL24.08, possible secreted protein, len: 238 aa; similar to TR:O07236 (EMBL:Z96800) Mycobacterium tuberculosis hypothetical 22.5 kD protein MTCY63.14, 218 aa; fasta scores: opt: 315 z-score: 359.1 E(): 1.4e-12; 31.2% identity in 218 aa overlap. Contains possible N-terminal region signal peptide sequence.
       0.457
SCO3396
SCE9.03c, possible membrane protein, len: 370 aa; unknown function, similar to SW:YLI2_CORGL (EMBL:X60312) Corynebacterium glutamicum hypothetical protein (426 aa), fasta scores; opt: 274 z-score: 307.1 E(): 8.8e-10, 23.9% identity in 351 aa overlap and TR:P94973 (EMBL:Z85982) Mycobacterium tuberculosis hypothetical protein (489 aa) (23.1% identity in 386 aa overlap). Contains hydrophobic regions at N-terminus, possibly a membrane anchor.
  
     0.439
SCO1569
SCL24.05c, possible oxidoreductase, len: 350 aa; similar to TR:AAF09836 (EMBL:AE001886) Deinococcus radiodurans oxidoreductase, putative DR0249, 357 aa; fasta scores: opt: 1019 z-score: 1133.1 E(): 0; 51.0% identity in 359 aa overlap.
  
    0.438
SCO4021
2SC10A7.25, probable two component system histidine kinase, len: 524 aa; similar to SW:AFQ2_STRCO (EMBL:D10654) Streptomyces coelicolor sensor protein AfsQ2 (EC 2.7.3.-), 535 aa; fasta scores: opt: 481 z-score: 498.8 E(): 2.8e-20; 29.0% identity in 517 aa overlap. Contains Pfam match to entry PF00672 DUF5, HAMP domain and PF00512 signal, Histidine kinase. Also contains possible N-terminal region signal peptide sequence.
 
     0.429
SCO6371
SC4A2.07, probable integral membrane protein, len: 279 aa; similar to TR:Q98E10 (EMBL:AP003004) Rhizobium loti (Mesorhizobium loti) putative integral membrane protein MLR4456 309 aa; fasta scores: opt: 899 Z-score: 1025.7 E(): 1.7e-49; 56.126% identity in 253 aa overlap.
  
     0.425
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.