STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO1869SCI39.16c, conserved hypothetical protein, len: 237 aa; similar to TR:O68911 (EMBL:AF058302) Streptomyces roseofulvus FrnE protein, 216 aa; fasta scores: opt: 528 Z-score: 605.5 bits: 119.3 E(): 3.9e-26; 46.919% identity in 211 aa overlap and to TR:Q9ZA40 (EMBL:AJ011500) Streptomyces violaceoruber putative disulphide bond-forming protein Gra-ORF19, 220 aa; fasta scores: opt: 316 Z-score: 366.6 bits: 75.1 E(): 7.9e-13; 37.104% identity in 221 aa overlap. (237 aa)    
Predicted Functional Partners:
SCO2206
SCO2206 protein; SC3H12.14, arsC, arsenate reductase (partial CDS), len: >47 aa; identical to N-terminal region of previously sequenced TR:Q9X954 (EMBL:Y13833) Streptomyces coelicolor arsenate reductase (fragment) ArsC, 117 aa and to SW:YGL1_STRVR (EMBL:X52842) Streptomyces viridochromogenes hypothetical 13.4 kD protein in GlnII region (ORF1), 119 aa; SC10B7.01, arsC, arsenate reductase (fragment), len: >117 aa; identical to previously sequenced TR:Q9X954 (EMBL:Y13833) Streptomyces coelicolor aresenate reductase (fragment), 117 aa, highly similar to SW:YGL1_STRVR (EMBL:X52842) Streptom [...]
   
 
 0.884
SCO1868
SCI39.15c, conserved hypothetical protein, len: 364 aa; similar to SW:YCBU_BACSU (EMBL:AB000617) Bacillus subtilis hypothetical protein homologue of class-V proteins of pyridoxal-phosphate-dependent aminotransferase YcbU, aa; fasta scores: opt: 277 Z-score: 303.9 bits: 64.9 E(): 2.5e-09; 27.707% identity in 314 aa overlap.
       0.807
SCO1870
Hypothetical protein SCI39.17c; SCI39.17c, unknown, len: 202 aa.
       0.784
SCO1871
SCI39.18c, probable aldehyde dehydrogenase, len: 509 aa; similar to TR:Q56694 (EMBL:U39638) Vibrio harveyi fatty aldehyde dehydrogenase AldH, 510 aa; fasta scores: opt: 1209 Z-score: 1264.1 bits: 243.5 E(): 8e-63; 42.300% identity in 487 aa overlap. Contains Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase family.
       0.703
SCO1872
SCI39.19, probable IclR-family transcriptional regulator, len: 257 aa; similar to SW:ICLR_ECOLI (EMBL:M31761) Escherichia coli acetate operon repressor IclR, 274 aa; fasta scores: opt: 413 Z-score: 491.6 bits: 98.6 E(): 8.7e-20;31.855% identity in 248 aa overlap and to TR:Q9RDE7 (EMBL:AL136503) Streptomyces coelicolor putative IclR-family transcriptional regulator SCC77.11, 265aa; fasta scores: opt: 766 Z-score: 904.5 bits: 175.0 E(): 8.6e-43; 52.846% identity in 246 aa overlap. Contains Pfam match to entry PF01614 IclR, Bacterial transcriptional regulator and possible helix-turn-helix [...]
       0.666
SCO1873
SCI39.20, probable acetyltransferase, len: 156 aa; similar to TR:Q9SKZ7 (EMBL:AC006223) Arabidopsis thaliana putative alanine acetyl transferase AT2G32020, 183 aa; fasta scores: opt: 205 Z-score: 253.5 bits: 53.3 E(): 1.6e-06; 31.210% identity in 157 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family.
       0.666
SCO2671
SC6D10.14, possible globin, len: 137 aa; similar to TR:O53197 (EMBL:AL021246) Mycobacterium tuberculosis putative globin, 128 aa; fasta scores: opt: 466 z-score: 620.8 E(): 3.6e-27; 53.6% identity in 125 aa overlap and to SW:GLBN_NOSSN (EMBL:L47979) Nostoc sp. cyanoglobin GlbN, 118 aa; fasta scores: opt: 170 z-score: 236.1 E(): 9.7e-06; 25.2% identity in 119 aa overlap. Contains Pfam match to entry PF01152 Bac_globin, Protozoan/cyanobacterial globin.
  
  
 0.565
SCO7741
SC8D11.32c, possible bifunctional protein, len: 354 aa; N-terminal region similar to TR:Q9RKU1 (EMBL:AL132824) Streptomyces coelicolor putative reductase SCAH10.16, 185 aa; fasta scores: opt: 387 z-score: 473.3 E(): 8e-19; 39.0% identity in 187 aa overlap and C-terminal region similar to SW:YIEF_ECOLI (EMBL:L10328) Escherichia coli hypothetical 20.4 kDa protein YieF, 188 aa; blastp scores: Score= 148 (52.1 bits), Expect= 7.0e-10, P= 7.0e-10; Identities= 49/139 (35%), Positives= 78/139 (56%). Contains Pfam match in C-terminal region to entry PF00583 Acetyltransf, Acetyltransferase (GNAT [...]
 
   0.473
SCO3295
SCE15.12c, possible oxidoreductase, len: 222aa; similar to TR:O85762 (EMBL:AF075709) NADH dependent FMN reductase from Pseudomonas putida (200 aa) fasta scores; opt: 208, z-score: 241.1, E(): 4e-06, (35.7% identity in 129 aa overlap).
 
    0.458
SCO6137
SC1A9.01c, possible transferase, partial CDS, len: 219 aa, similar to TR:O53185 (EMBL:AL021246) a proposed transferase from Mycobacterium tuberculosis (302 aa), fasta scores: opt: 764, z-score: 1097.3, E(): 0, (62.1% identity in 203 aa overlap (302 aa). Also weakly similar to several methyltransferases eg. METH_ECOLI (EMBL:X16584)5-methyltetrahydrofolate-homocysteine methyltransferase (1226 aa), fasta scores; opt:160, z-score: 234.8, E(): 8.4e-06, (30.0% identity in 220 aa overlap); SC9B2.24c, partial CDS, possible transferase, len: 113aa; constitutes the C-terminal end of SC1A9.01c (E [...]
   
    0.442
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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