STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO1876SCI39.23, possible RNA polymerase sigma factor, len: 190 aa; similar to SW:RPOE_STRCO (EMBL:L29636) Streptomyces coelicolor RNA polymerase sigma-E factor SigE, 176 aa; fasta scores: opt: 210 Z-score: 262.1 bits: 55.1 E(): 5.2e-07; 34.177% identity in 158 aa overlap. Contains possible helix-turn-helix motif at residues 132..153 (+3.59 SD); Belongs to the sigma-70 factor family. ECF subfamily. (190 aa)    
Predicted Functional Partners:
SCO1877
Hypothetical protein SCI39.24; SCI39.24, unknown, len: 224 aa.
       0.875
SCO1861
SCI39.08c, conserved hypothetical protein, len: 363 aa; similar to SW:YT15_MYCTU (EMBL:Z74697) Mycobacterium tuberculosis hypothetical 39.8 kDa protein RV2915c, 370 aa; fasta scores: opt: 1341 Z-score: 1487.0 bits: 283.8 E(): 3.1e-75; 56.630% identity in 362 aa overlap.
 
     0.679
SCO3324
SCE68.22, hypothetical protein, len: 419 aa; unknown function, probable serine-rich CDS suggested by positional base preference, GC frame analysis and amino acid composition. An alternative start codon is present at codon 4.
   
   0.660
SCO1875
SCI39.22, possible secreted penicillin-binding protein, len: 484 aa; similar to TR:Q9L656 (EMBL:AF241575) Streptomyces griseus PbpA, 485 aa; fasta scores: opt: 1581 Z-score: 1674.1 bits: 319.2 E(): 1.2e-85; 51.633% identity in 490 aa overlap and to TR:Q9XA17 (EMBL:AL079308) Streptomyces coelicolor putative penicillin binding protein SCH69.17, 490 aa; fasta scores: opt: 1649 Z-score: 1745.9 bits: 332.5 E(): 1.2e-89; 52.965% identity in 489 aa overlap. Contains Pfam match to entry PF00905 Transpeptidase, Penicillin binding protein transpeptidase domain and match to Prosite entry PS00017 [...]
       0.569
SCO5934
SC7H1.04, possible sigma factor, len: 200 aa; some similarity to sigma factors (ECF subfamily) from diverse organisms e.g. Alcaligenes eutrophus CNRH_ALCEU P37978 rna polymerase sigma factor cnrh (191 aa), fasta scores; opt: 230 z-score: 337.3 E(): 1.4e-11, 29.5% identity in 183 aa overlap; Belongs to the sigma-70 factor family. ECF subfamily.
  
   
 0.490
SCO1872
SCI39.19, probable IclR-family transcriptional regulator, len: 257 aa; similar to SW:ICLR_ECOLI (EMBL:M31761) Escherichia coli acetate operon repressor IclR, 274 aa; fasta scores: opt: 413 Z-score: 491.6 bits: 98.6 E(): 8.7e-20;31.855% identity in 248 aa overlap and to TR:Q9RDE7 (EMBL:AL136503) Streptomyces coelicolor putative IclR-family transcriptional regulator SCC77.11, 265aa; fasta scores: opt: 766 Z-score: 904.5 bits: 175.0 E(): 8.6e-43; 52.846% identity in 246 aa overlap. Contains Pfam match to entry PF01614 IclR, Bacterial transcriptional regulator and possible helix-turn-helix [...]
  
    0.489
SCO0781
3SCF60.13, possible anti sigma factor antagonist, len: 166 aa; C-terminal region identical to TR:O85703 (EMBL:AF072709) Streptomyces lividans hypothetical 14.3 kDa protein, 128 aa and similar to SW:RSBV_STRCO (EMBL:AF134889) Streptomyces coelicolor anti-sigma B factor antagonist BldG, 113 aa; fasta scores: opt: 199 z-score: 266.9 E(): 2.4e-07; 31.5% identity in 108 aa overlap. Contains Pfam match to entry PF01740 STAS, STAS domain.
  
  
 0.480
SCO7619
SC2H2.17, probable anti sigma factor antagonist, len: 134 aa; similar to SW:RSBV_STRCO (EMBL:AF134889) Streptomyces coelicolor anti-sigma B factor antagonist RsvB or BldG or SCH5.12c, 113 aa; fasta scores: opt: 263 z-score: 348.2 E(): 7.3e-12; 41.2% identity in 97 aa overlap. Contains Pfam match to entry PF01740 STAS, STAS domain; Belongs to the anti-sigma-factor antagonist family.
  
  
 0.478
SCO4401
SCD10.33c, possible lipoprotein, len: 438 aa; N-terminal domain similar to N-terminal domain of TR:O68027 (EMBL:AF010496) Rhodobacter capsulatus potential Leu/Ile/Val-binding protein precursor, 400 aa; fasta scores: opt: 151 z-score: 166.0 E(): 0.09; 29.8% identity in 131 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence.
  
     0.467
SCO1723
SCI11.12c, possible RNA polymerase sigma factor, len: 185 aa; weakly similar to RNA polymerase sigma factors e.g. SW:CARQ_MYXXA (EMBL:X71062), CarQ, Myxococcus xanthus RNA polymerase sigma factor (174 aa), fasta scores; opt: 233 z-score: 295.7 E(): 3.9e-09, 29.3% identity in 167 aa overlap. Similar to many putative sigma factors e.g. TR:O53730 (EMBL:AL021932), SigK, Mycobacterium tuberculosis probable RNA polymerase sigma factor (187 aa) (51.4% identity in 173 aa overlap). Similar to others from S.coelicolor e.g. TR:O54163 (EMBL:AL021411) S. coelicolor possible sigma factor (200 aa) (3 [...]
  
   
 0.449
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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