STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
SCO1934Putative cytochrome oxidase assembly factor; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (340 aa)    
Predicted Functional Partners:
SCO2151
SC6G10.24c, cox3, cytochrome c oxidase subunit III, len: 206aa; similar to many eg. SW:COX3_BACP3 caaC, cytochrome c oxidase subunit III from Bacillus PS3 (207 aa) fasta scores; opt: 397, z-score: 511.9, E(): 3.3e-21, (35.9% identity in 181 aa overlap). Contains Pfam match to entry PF00510 COX3, Cytochrome c oxidase subunit III.
 
 
 0.999
SCO2156
Putative cytochrome c oxidase subunit II; Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity).
 
 
 0.999
SCO1930
SCC22.12, possible integral membrane transport protein, len: 356aa; function predicted as it contains possible membrane spanning hydrophobic regions and is located alongside a possible ABC transport ATP-binding protein (SCC22.10). Similar to TR:O53148 (EMBL:AL021184) hypothetical protein from Mycobacterium tuberculosis (310 aa) fasta scores; opt: 527, z-score: 648.1, E(): 9.2e-29, (35.0% identity in 300 aa overlap).
 
 0.998
SCO7234
Cytochrome C oxidase polypeptide I; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity).
 
 0.998
SCO2155
Putative cytochrome c oxidase subunit I; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity).
 
 0.997
SCO5859
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
  
 
 0.938
SCO7236
SC7A12.03c, qcrB3, ubiquinol-cytochrome C reductase cytochrome subunit B, len: 554 aa. Highly similar to many including: Streptomyces lividans SW:QCRB_STRLI(EMBL:AF107888) ubiquinol-cytochrome C reductase cytochrome subunit B (549 aa), fasta scores opt: 1808 z-score: 1914.0 E():0 51.9% identity in 528 aa overlap and Streptomyces coelicolor SW:QCRB_STRCO (EMBL:AL049497) ubiquinol-cytochrome C reductase cytochrome subunit B, QcrB OR SC6G10.21c (545 aa), opt: 2016 z-score: 2133.7 E():0 55.0% identity in 522 aa overlap. Contains a Pfam match to entry PF00033 cytochrome_b_N, Cytochrome b(N- [...]
 
 
 0.905
SCO2267
SCC75A.13, probable heme oxygenase, len: 215 aa. Highly similar to many Eukaryotic and several Prokaryotic heme oxygenases including: Gallus gallus (Chicken) SW:HO_CHICK (EMBL:X56201) (296 aa), fasta scores opt: 485 z-score: 601.9 E(): 3.8e-26 37.6% identity in 205 aa overlap and Corynebacterium diphtheriae SW:HMUO_CORDI (EMBL:U73860)(215 aa), fasta scores opt: 463 z-score: 577.0 E(): 9.2e-25 41.5% identity in 205 aa overlap. Contains a Pfam match to entry PF01126 Heme_oxygenase, Heme oxygenase.
     
 0.904
SCO7120
SC4B10.21, qcrB2, ubiquinol-cytochrome C reductase cytochrome B subunit, len: 539 aa; similar to SW:QCRB_STRCO (EMBL:AL049497) Streptomyces coelicolor ubiquinol-cytochrome C reductase cytochrome B subunit QcrB or SC6G10.21c, 545 aa; fasta scores: opt: 2311 z-score: 2220.7 E(): 0; 59.4% identity in 537 aa overlap and to SW:QCRB_STRLI (EMBL:AF107888) Streptomyces lividans ubiquinol-cytochrome C reductase cytochrome B subunit QcrB, 549 aa; fasta scores: opt: 2148 z-score: 2064.6 E(): 0; 56.3% identity in 542 aa overlap. Contains Pfam match to entry PF00033 cytochrome_b_N, Cytochrome b(N-t [...]
 
 
 0.890
SCO1933
Hypothetical protein; SCC22.15c, unknown, len: 144aa.
       0.854
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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