STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO1938SCC22.20, hypothetical protein, len: 351 aa; similar to TR:O88016 (EMBL:AL031107) hypothetical protein from Streptomyces coelicolor (311 aa) fasta scores; opt: 1363, z-score: 1605.9, E(): 0, (71.3% identity in 300 aa overlap) and TR:O06813 (EMBL:Z95844) hypothetical protein from Mycobacterium tuberculosis (303 aa) fasta scores; opt: 849, z-score: 1002.6, E(): 0, (46.3% identity in 309 aa overlap). (351 aa)    
Predicted Functional Partners:
SCO1939
Putative 6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
  
 0.976
SCO1937
Putative glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone.
 
  
 0.909
SCO1936
Putative transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily.
  
  
 0.870
SCO1935
Transketolase A; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
     
 0.752
SCO2078
SC4A10.11c, putative membrane protein, len: 94 aa; unknown function, similar to hypothetical proteins e.g. TR:O06230 (EMBL:Z95388) Mycobacterium tuberculosis hypothetical protein (96 aa), fasta scores; opt: 262 z-score: 367.1 E(): 4e-13, 41.9% identity in 86 aa overlap. Contains possible hydrophobic membrane spanning regions.
  
     0.658
SCO1421
Hypothetical protein SC6D7.18c; Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters. Stimulates transcription from several principal sigma factor HrdB (SigA)-dependent promoters but not from a SigR-dependent promoter. Stimulation occurs in the presence of the transcription initiation inhibitor rifampicin (Rif).
  
     0.653
SCO6661
Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone.
 
  
 0.615
SCO5864
Conserved hypothetical protein; SC2E9.05, unknown, len: 98 aa; highly similar to hypothetical proteins from Mycobacterium tuberculosis and M. leprae eg. TR:O07201 (EMBL:Z96072) MTCY05A6.20C (100 aa), fasta scores; opt: 465 z-score: 814.5 E(): 0, 71.4% identity in 98 aa overlap.
  
     0.592
SCO5869
SC2E9.10, unknown, len: 250 aa; similar to hypothetical proteins from Mycobacterium tuberculosis and M. leprae eg. TR:O07198 (EMBL:Z96072) MTCY05A6.17C (259 aa), fasta scores; opt: 213 z-score: 435.8 E(): 4.5e-17, 28.2% identity in 255 aa overlap. Contains possible coiled-coil domain from aa 1-40.
  
     0.539
SCO1934
Putative cytochrome oxidase assembly factor; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
     
 0.520
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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