STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO1968SC3C9.03, probable secreted hydrolase, len: 289 aa; similar to SW:GLPQ_BACSU (EMBL:Z26522) Bacillus subtilis glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46) GlpQ, 293 aa; fasta scores: opt: 495 Z-score: 576.9 bits: 114.7 E(): 1.6e-24; 34.114% identity in 299 aa overlap. Contains possible cleavable N-terminal region signal peptide sequence. (289 aa)    
Predicted Functional Partners:
SCO1969
Putative DNA-methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
 
     0.852
SCO0509
Glycerol kinase 2 (ATP:glycerol 3-phosphotransferase) (EC 2.7.1.30); Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.
 
  
 0.768
SCO0580
SCF55.04c, possible glycerone kinase, len: 593 aa; similar to SW:DHAK_YEAST (EMBL:D50617) Saccharomyces cerevisiae dihydroxyacetone kinase 2 (EC 2.7.1.29) (glycerone kinase) Dak2, 591 aa; fasta scores: opt: 646 z-score: 660.2 E(): 2.1e-29; 29.9% identity in 561 aa overlap.
   
  
 0.760
SCO2401
SC4A7.29, possible dehydratase, len: 388 aa; similar to C-terminal region of SW:DGOA_ECOLI (EMBL:L10328) Escherichia coli galactonate dehydratase (EC 4.2.1.6) GdoA, 587 aa; fasta scores: opt: 751 z-score: 864.7 E(): 0; 35.0% identity in 383 aa overlap. Contains Pfam match to entry PF01188 MR_MLE, Mandelate racemase / muconate lactonizing enzyme family.
      
 0.753
SCO1660
Putative glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.
 
  
 0.738
SCO1966
ABC excision nuclease subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissoc [...]
     
 0.706
SCO6754
SC6A5.03, possible glycerol dehydrogenase, len: 340aa; similar to many eg. SW:GLDA_PSEPU glycerol dehydrogenase, GldA, from Pseudomonas putida (365 aa) fasta scores; opt: 261, z-score: 303.7, E(): 1.3e-09, (27.9% identity in 308 aa overlap).
     
 0.681
SCO1965
SCC54.25c, possible export associated protein, len: 192aa; similar to many associated with plasmid borne resistance export systems egs. TR:Q52353 (EMBL:L38824) from the IncHI2 plasmid R478 of Serratia marcescens (193 aa) fasta scores; opt: 497, z-score: 593.2, E(): 9.8e-26, (42.2% identity in 192 aa overlap) and SW:TERD_ALCSP terD, tellurium resistance protein from the pMER610 plasmid of Alcaligenes sp. (192 aa) fasta scores; opt: 357, z-score: 429.6, E(): 1.3e-16, (37.2% identity in 188 aa overlap).
       0.658
SCO7004
SC8F11.30, probable carbohydrate kinase,len: 479 aa. Highly similar to many e.g. Bacillus subtilis SW:GLPK_BACSU(EMBL:M34393) glycerol kinase (EC 2.7.1.30), GlpK (496 aa), fasta scores opt: 688 z-score: 766.4 E():0 35.1% identity in 496 aa overlap. Contains a Pfam match to entry PF00370 FGGY, FGGY family of carbohydrate kinases.
 
  
 0.568
SCO1971
Conserved hypothetical protein; Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway; Belongs to the pseudouridine-5'-phosphate glycosidase family.
       0.516
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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