STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO2100SC4A10.33, probable transcriptional regulator, len: 209 aa; shows weak similarity to many hypothetical proteins e.g. TR:O53641 (EMBL:AL021927) Mycobacterium tuberculosis hypothetical protein (214 aa), fasta scores; opt: 224 z-score: 282.1 E(): 2.2e-08, 28.8% identity in 208 aa overlap and to SCI30A.20c (EMBL:AL096811) S.coelicolor possible transcriptional regulator (215 aa) (31.6% identity in 190 aa overlap). Contains probable helix-turn-helix motif at aa 38-59 (Score 1454, +4.14 SD) and Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family. (209 aa)    
Predicted Functional Partners:
SCO2101
SC4A10.34, probable carotenoid dehydrogenase (putative secreted protein), len: 506 aa; similar to many bacterial and fungal carotenoid dehydrogenases e.g. SW:CRTD_RHOSH (EMBL:X63204) CrtD, Rhodobacter sphaeroides methoxyneurosporene dehydrogenase (495 aa), fasta scores; opt: 470 z-score: 505.2 E(): 8.1e-21, 29.2% identity in 506 aa overlap. Shows very weak similarity to TR:Q9ZBG4 (EMBL:AL035206) S. coelicolor possible dehydrogenase (472 aa) (28.1% identity in 523 aa overlap). Contains possible N-terminal region signal peptide sequence.
     
 0.894
SCO3287
SCE15.04, serine/arginine rich protein, len: 172aa.
      
 0.719
SCO3871
SCH18.08, possible decarboxylase, len: 136 aa; similar to TR:O26336 (EMBL:AE000810) Methanobacterium thermoautotrophicum gamma-carboxymuconolactone decarboxylase Mth234, 125 aa; fasta scores: opt: 231 z-score: 310.2 E(): 8.3e-10; 38.3% identity in 107 aa overlap.
  
   
 0.712
SCO2098
SC4A10.31c, possible methyltransferase, len: 271 aa; shows weak similarity to SW:SMTA_ECOLI (EMBL:D26440), SmtA, Escherichia coli S-adenosylmethionine-dependent methyltransferase (261 aa), fasta scores; opt: 311 z-score: 330.3 E(): 4.5e-11, 32.0% identity in 250 aa overlap and to SC5F7.31 (EMBL:AL096872) S.coelicolor possible methyltransferase (233 aa) (34.3% identity in 236 aa overlap).
       0.679
SCO2822
SCBAC17F8.13c, possible decarboxylase, len: 243 aa: similar to many e.g. SW:Q05115 (AMDA_BORBR) arylmalonate decarboxylase from Alcaligenes bronchisepticus (240 aa) fasta scores; opt: 258, Z-score: 293.3, 33.333% identity (34.302% ungapped) in 177 aa overlap. Almost identical to TR:Q54412 (EMBL:X52071) hypothetical protein which close alongside transfer RNA-gly in Streptomyces lividans (195 aa) fasta scores; opt: 1233, Z-score: 1358.6, 98.980% identity (99.487% ungapped) in 196 aa overlap. Also similar to neighbouring CDS SCBAC17F8.14c.
      
 0.669
SCO0627
SCF56.11c, possible ATP utilising protein, len: 709 aa; low similarities to TR:O34180 (EMBL:U95372) Halobacterium volcanii hydantoinase, 514 aa; fasta scores: opt: 462 z-score: 480.2 E(): 2.3e-19; 28.9% identity in 575 aa overlap and to SW:OPLA_RAT (EMBL:U70825) Rattus norvegicus 5-oxoprolinase (EC 3.5.2.9), 1288 aa; fasta scores: opt: 255 z-score: 261.5 E(): 3.5e-07; 26.9% identity in 547 aa overlap. Contains match to Prosite entry PS00107 Protein kinases ATP-binding region signature.
      
 0.667
SCO2347
SCC8A.05c, possible integral membrane protein, len: aa; similar to others of undefined function eg. TR:P96229 (EMBL:Z83864) hypothetical 32.0 kD protein from Mycobacterium tuberculosis (302 aa) fasta scores; opt: 245, z-score: 295.9, E(): 5.1e-09, 32.8% identity in 195 aa overlap. Contains possible membrane-spanning hydrophobic regions and Pfam match to entry PF01169 UPF0016, Uncharacterized protein family UPF0016.
      
 0.667
SCO4676
Hypothetical protein; SCD31.01c, unknown (fragment), len: >147 aa; SCD40A.22c, unknown (fragment), len: > 176 aa.
      
 0.646
SCO2097
SC4A10.30c, possible membrane protein, len: 135 aa; unknown function, similar to mycobacterial hypothetical proteins TR:O53503 (EMBL:AL021957) Mycobacterium tuberculosis (134 aa), fasta scores; opt: 349 z-score: 414.6 E(): 9e-16, 44.1% identity in 136 aa overlap and its homologue in Mycobacterium leprae TR:O69562 (EMBL:AL022602) Mycobacterium leprae hypothetical protein (134 aa) (42.6% identity in 136 aa overlap). Contains hydrophobic, possible membrane-spanning regions.
       0.636
SCO6265
SCAH10.30c, scbR, gamma-butyrolactone binding protein, len: 215 aa; identical to previously sequenced TR:O86852 (EMBL:AJ007731) Streptomyces coelicolor gamma-butyrolactone binding protein, 215 aa and to TR:O24741 (EMBL:AB001683) Streptomyces sp. FarA, 221 aa; fasta scores: opt: 771 z-score: 937.4 E(): 0; 57.2% identity in 208 aa overlap. Contains match to Pfam entry PF00440 tetR, Bacterial regulatory proteins, tetR family and to Prosite entry PS01081 Bacterial regulatory proteins, tetR family signature. Contains also a possible helix-turn-helix motif at residues 30..51 (+3.66 SD).
  
     0.538
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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